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Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma.
J Clin Med. 2020 Jul 08; 9(7)JC

Abstract

Non-erosive reflux disease (NERD) and esophageal adenocarcinoma (EAC) are often regarded as bookends in the gastroesophageal reflux disease spectrum. However, there is limited clinical evidence to support this disease paradigm while the underlying mechanisms of disease progression remain unclear. In this study, we used 16S rRNA sequencing and mass-spectrometer-based proteomics to characterize the esophageal microbiota and host mucosa proteome, respectively. A total of 70 participants from four patient groups (NERD, reflux esophagitis, Barrett's esophagus, and EAC) and a control group were analyzed. Our results showed a unique NERD microbiota composition, distinct to control and other groups. We speculate that an increase in sulfate-reducing Proteobacteria and Bacteroidetes along with hydrogen producer Dorea are associated with a mechanistic role in visceral hypersensitivity. We also observed a distinct EAC microbiota consisting of a high abundance of lactic acid-producing bacteria (Staphylococcus, Lactobacillus, Bifidobacterium, and Streptococcus), which may contribute towards carcinogenesis through dysregulated lactate metabolism. This study suggests the close relationship between esophageal mucosal microbiota and the appearance of pathologies of this organ.

Authors+Show Affiliations

School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW 2750, Australia.School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.Department of Gastroenterology, Campbelltown Hospital, Campbelltown, NSW 2560, Australia.School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia. Department of Gastroenterology, Campbelltown Hospital, Campbelltown, NSW 2560, Australia.Nepean Hospital, Kingswood, NSW 2747, Australia.School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia. Department of Gastroenterology, Campbelltown Hospital, Campbelltown, NSW 2560, Australia.School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia. Department of Gastroenterology, Campbelltown Hospital, Campbelltown, NSW 2560, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32650561

Citation

Zhou, Jerry, et al. "Distinct Microbiota Dysbiosis in Patients With Non-Erosive Reflux Disease and Esophageal Adenocarcinoma." Journal of Clinical Medicine, vol. 9, no. 7, 2020.
Zhou J, Shrestha P, Qiu Z, et al. Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma. J Clin Med. 2020;9(7).
Zhou, J., Shrestha, P., Qiu, Z., Harman, D. G., Teoh, W. C., Al-Sohaily, S., Liem, H., Turner, I., & Ho, V. (2020). Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma. Journal of Clinical Medicine, 9(7). https://doi.org/10.3390/jcm9072162
Zhou J, et al. Distinct Microbiota Dysbiosis in Patients With Non-Erosive Reflux Disease and Esophageal Adenocarcinoma. J Clin Med. 2020 Jul 8;9(7) PubMed PMID: 32650561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma. AU - Zhou,Jerry, AU - Shrestha,Prapti, AU - Qiu,Zhiguang, AU - Harman,David G, AU - Teoh,Wun-Chung, AU - Al-Sohaily,Sam, AU - Liem,Han, AU - Turner,Ian, AU - Ho,Vincent, Y1 - 2020/07/08/ PY - 2020/06/04/received PY - 2020/07/03/revised PY - 2020/07/06/accepted PY - 2020/7/12/entrez PY - 2020/7/12/pubmed PY - 2020/7/12/medline KW - Barrett’s esophagus KW - esophageal adenocarcinoma KW - gastroesophageal reflux disease KW - microbiome KW - non-erosive reflux disease KW - proteome KW - reflux esophagitis JF - Journal of clinical medicine JO - J Clin Med VL - 9 IS - 7 N2 - Non-erosive reflux disease (NERD) and esophageal adenocarcinoma (EAC) are often regarded as bookends in the gastroesophageal reflux disease spectrum. However, there is limited clinical evidence to support this disease paradigm while the underlying mechanisms of disease progression remain unclear. In this study, we used 16S rRNA sequencing and mass-spectrometer-based proteomics to characterize the esophageal microbiota and host mucosa proteome, respectively. A total of 70 participants from four patient groups (NERD, reflux esophagitis, Barrett's esophagus, and EAC) and a control group were analyzed. Our results showed a unique NERD microbiota composition, distinct to control and other groups. We speculate that an increase in sulfate-reducing Proteobacteria and Bacteroidetes along with hydrogen producer Dorea are associated with a mechanistic role in visceral hypersensitivity. We also observed a distinct EAC microbiota consisting of a high abundance of lactic acid-producing bacteria (Staphylococcus, Lactobacillus, Bifidobacterium, and Streptococcus), which may contribute towards carcinogenesis through dysregulated lactate metabolism. This study suggests the close relationship between esophageal mucosal microbiota and the appearance of pathologies of this organ. SN - 2077-0383 UR - https://www.unboundmedicine.com/medline/citation/32650561/Distinct_Microbiota_Dysbiosis_in_Patients_with_Non-Erosive_Reflux_Disease_and_Esophageal_Adenocarcinoma L2 - https://www.mdpi.com/resolver?pii=jcm9072162 DB - PRIME DP - Unbound Medicine ER -
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