Tags

Type your tag names separated by a space and hit enter

Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study).
Am J Cardiol. 2020 Aug 01; 128:45-53.AJ

Abstract

Early-onset cardiomyopathy is a major concern for people with type 1 diabetes mellitus (DM). Studies examining myocardial deformation indices early in the disease process in people with have provided conflicting results. Accordingly, the objective was to examine left ventricular (LV) function in adolescents with type 1 DM using novel measures of cardiomyopathy, termed ventricular discoordination indices, including systolic stretch fraction (SSF), and our newly developed diastolic relaxation fraction (DRF). Adolescents with DM (n = 16) and healthy controls (n = 20) underwent cardiac MRI (CMR) tissue tracking analysis for standard volumetric and functional analysis. Segment-specific circumferential strain and strain rate indices were evaluated to calculate standard mechanical dyssynchrony and discoordination. SSF and DRF were calculated from strain rate data. There were no global or regional group differences between participants with DM and controls in standard LV strain mechanics. However, youth with DM had lower diastolic strain rate around the inferior septal and free wall region (all p <0.05) as well as higher SSF (p = 0.03) and DRF (p <0.001) compared with controls. None of the CMR indices correlated with HbA1c or diabetes duration. In conclusion, our results suggest that adolescents with DM have LV systolic and diastolic discoordination, providing early evidence of cardiomyopathy despite their young age. The presence of discoordination in the setting of normal LV size and function suggests that the proposed novel discoordination indices could serve as a more sensitive marker of cardiomyopathy than previously employed mechanical deformation indices.

Authors+Show Affiliations

Division of Pediatric Cardiology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado. Electronic address: michal.schafer@cuanschutz.edu.Section of Pediatric Endocrinology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.Division of Pediatric Cardiology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.Section of Pediatric Endocrinology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado; Division of Nephrology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.Division of Pediatric Cardiology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.Division of Endocrinology, Rocky Mountain Regional VAMC, Colorado; Department of Bioengineering, University of Colorado Denver | Anschutz Medical Campus, Denver, Colorado.Division of Pediatric Cardiology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.Division of Congenital Cardiac Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado.Division of Pediatric Cardiology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.Department of Bioengineering, University of Colorado Denver | Anschutz Medical Campus, Denver, Colorado; Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado.Division of Endocrinology, Rocky Mountain Regional VAMC, Colorado.Section of Pediatric Endocrinology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado; Division of Nephrology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32650923

Citation

Schäfer, Michal, et al. "Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study)." The American Journal of Cardiology, vol. 128, 2020, pp. 45-53.
Schäfer M, Bjornstad P, Frank BS, et al. Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study). Am J Cardiol. 2020;128:45-53.
Schäfer, M., Bjornstad, P., Frank, B. S., Baumgartner, A., Truong, U., Enge, D., von Alvensleben, J. C., Mitchell, M. B., Ivy, D. D., Barker, A. J., Reusch, J. E. B., & Nadeau, K. J. (2020). Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study). The American Journal of Cardiology, 128, 45-53. https://doi.org/10.1016/j.amjcard.2020.04.041
Schäfer M, et al. Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study). Am J Cardiol. 2020 Aug 1;128:45-53. PubMed PMID: 32650923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study). AU - Schäfer,Michal, AU - Bjornstad,Petter, AU - Frank,Benjamin S, AU - Baumgartner,Amy, AU - Truong,Uyen, AU - Enge,Daniel, AU - von Alvensleben,Johannes C, AU - Mitchell,Max B, AU - Ivy,D Dunbar, AU - Barker,Alex J, AU - Reusch,Jane E B, AU - Nadeau,Kristen J, Y1 - 2020/05/13/ PY - 2020/02/27/received PY - 2020/04/16/revised PY - 2020/04/20/accepted PY - 2020/7/12/entrez PY - 2020/7/12/pubmed PY - 2020/7/12/medline SP - 45 EP - 53 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 128 N2 - Early-onset cardiomyopathy is a major concern for people with type 1 diabetes mellitus (DM). Studies examining myocardial deformation indices early in the disease process in people with have provided conflicting results. Accordingly, the objective was to examine left ventricular (LV) function in adolescents with type 1 DM using novel measures of cardiomyopathy, termed ventricular discoordination indices, including systolic stretch fraction (SSF), and our newly developed diastolic relaxation fraction (DRF). Adolescents with DM (n = 16) and healthy controls (n = 20) underwent cardiac MRI (CMR) tissue tracking analysis for standard volumetric and functional analysis. Segment-specific circumferential strain and strain rate indices were evaluated to calculate standard mechanical dyssynchrony and discoordination. SSF and DRF were calculated from strain rate data. There were no global or regional group differences between participants with DM and controls in standard LV strain mechanics. However, youth with DM had lower diastolic strain rate around the inferior septal and free wall region (all p <0.05) as well as higher SSF (p = 0.03) and DRF (p <0.001) compared with controls. None of the CMR indices correlated with HbA1c or diabetes duration. In conclusion, our results suggest that adolescents with DM have LV systolic and diastolic discoordination, providing early evidence of cardiomyopathy despite their young age. The presence of discoordination in the setting of normal LV size and function suggests that the proposed novel discoordination indices could serve as a more sensitive marker of cardiomyopathy than previously employed mechanical deformation indices. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/32650923/Frequency_of_Reduced_Left_Ventricular_Contractile_Efficiency_and_Discoordinated_Myocardial_Relaxation_in_Patients_Aged_16_to_21_Years_With_Type_1_Diabetes_Mellitus_(from_the_Emerald_Study) L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(20)30463-X DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.