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Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain.
Rev Esp Patol. 2020 Jul - Sep; 53(3):188-192.RE

Abstract

The new coronavirus SARS-CoV-2, first identified in Wuhan, China in December, 2019, can cause Severe Acute Respiratory Syndrome (SARS) with massive alveolar damage and progressive respiratory failure. We present the relevant autopsy findings of the first patient known to have died from COVID19 pneumonia in Spain, carried out on the 14th of February, 2020, in our hospital (Hospital Arnau de Vilanova-Lliria, Valencia). Histological examination revealed typical changes of diffuse alveolar damage (DAD) in both the exudative and proliferative phase of acute lung injury. Intra-alveolar multinucleated giant cells, smudge cells and vascular thrombosis were present. The diagnosis was confirmed by reverse real-time PCR assay on a throat swab sample taken during the patient's admission. The positive result was reported fifteen days subsequent to autopsy.

Links

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Authors+Show Affiliations

Navarro Conde P
Servicio de Anatomía Patológica, Hospital Arnau de Vilanova-Lliria, Valencia, Spain. Electronic address: navarro_ped@gva.es.
Alemany Monraval P
Servicio de Anatomía Patológica, Hospital Arnau de Vilanova-Lliria, Valencia, Spain.
Medina Medina C
Servicio de Anatomía Patológica, Hospital Arnau de Vilanova-Lliria, Valencia, Spain.
Jiménez Sánchez A
Servicio de Anatomía Patológica, Hospital Arnau de Vilanova-Lliria, Valencia, Spain.
Andrés Teruel JC
Servicio de Radiodiagnóstico, Hospital Arnau de Vilanova-Llíria, Valencia, Spain.
Ferrando Marco J
Servicio de Anatomía Patológica, Hospital Arnau de Vilanova-Lliria, Valencia, Spain.
Puglia Santos V
Servicio de Anatomía Patológica, Hospital Arnau de Vilanova-Lliria, Valencia, Spain.
Mayordomo Aranda E
Subdirectora Médica, Hospital Arnau de Vilanova-Lliria, Valencia, Spain.

MeSH

AgedAlveolar Epithelial CellsAnion Exchange Protein 1, ErythrocyteAntigens, CDAntigens, Differentiation, MyelomonocyticAutopsyBetacoronavirusCOVID-19COVID-19 TestingCarcinoma, Transitional CellChinaClinical Laboratory TechniquesCommunity-Acquired InfectionsCoronavirus InfectionsDNA-Binding ProteinsHumansLungMacrophagesMalePandemicsPneumoniaPneumonia, ViralRespiratory Distress SyndromeSARS-CoV-2SpainTranscription FactorsTravelUrinary Bladder Neoplasms

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32650970

Citation

Navarro Conde, Pedro, et al. "Autopsy Findings From the First Known Death From Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain." Revista Espanola De Patologia : Publicacion Oficial De La Sociedad Espanola De Anatomia Patologica Y De La Sociedad Espanola De Citologia, vol. 53, no. 3, 2020, pp. 188-192.
Navarro Conde P, Alemany Monraval P, Medina Medina C, et al. Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain. Rev Esp Patol. 2020;53(3):188-192.
Navarro Conde, P., Alemany Monraval, P., Medina Medina, C., Jiménez Sánchez, A., Andrés Teruel, J. C., Ferrando Marco, J., Puglia Santos, V., & Mayordomo Aranda, E. (2020). Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain. Revista Espanola De Patologia : Publicacion Oficial De La Sociedad Espanola De Anatomia Patologica Y De La Sociedad Espanola De Citologia, 53(3), 188-192. https://doi.org/10.1016/j.patol.2020.04.002
Navarro Conde P, et al. Autopsy Findings From the First Known Death From Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain. Rev Esp Patol. 2020 Jul - Sep;53(3):188-192. PubMed PMID: 32650970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autopsy findings from the first known death from Severe Acute Respiratory Syndrome SARS-CoV-2 in Spain. AU - Navarro Conde,Pedro, AU - Alemany Monraval,Pilar, AU - Medina Medina,Carmen, AU - Jiménez Sánchez,Ana, AU - Andrés Teruel,Juan Carlos, AU - Ferrando Marco,José, AU - Puglia Santos,Víctor, AU - Mayordomo Aranda,Empar, Y1 - 2020/05/11/ PY - 2020/04/03/received PY - 2020/04/29/revised PY - 2020/04/29/accepted PY - 2020/7/12/entrez PY - 2020/7/12/pubmed PY - 2020/7/25/medline KW - Autopsia KW - Autopsy KW - COVID-19 KW - Daño alveolar difuso KW - Diffuse alveolar damage KW - SARS-CoV-2 SP - 188 EP - 192 JF - Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia JO - Rev Esp Patol VL - 53 IS - 3 N2 - The new coronavirus SARS-CoV-2, first identified in Wuhan, China in December, 2019, can cause Severe Acute Respiratory Syndrome (SARS) with massive alveolar damage and progressive respiratory failure. We present the relevant autopsy findings of the first patient known to have died from COVID19 pneumonia in Spain, carried out on the 14th of February, 2020, in our hospital (Hospital Arnau de Vilanova-Lliria, Valencia). Histological examination revealed typical changes of diffuse alveolar damage (DAD) in both the exudative and proliferative phase of acute lung injury. Intra-alveolar multinucleated giant cells, smudge cells and vascular thrombosis were present. The diagnosis was confirmed by reverse real-time PCR assay on a throat swab sample taken during the patient's admission. The positive result was reported fifteen days subsequent to autopsy. SN - 1988-561X UR - https://www.unboundmedicine.com/medline/citation/32650970/Autopsy_findings_from_the_first_known_death_from_Severe_Acute_Respiratory_Syndrome_SARS_CoV_2_in_Spain_ DB - PRIME DP - Unbound Medicine ER -