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IL-17 predicts the effect of TACE combined with apatinib in hepatocellular carcinoma.
Clin Hemorheol Microcirc. 2020 Jul 09 [Online ahead of print]CH

Abstract

OBJECTIVE

IL-17 is considered to be a cancer-promoting gene in hepatocellular carcinoma (HCC). Here, we explored the effect of IL-17 in predicting the therapeutic effect of transcatheter arterial chemoembolization (TACE) combined with apartinib in patients with HCC in this study.

METHODS

Established of IL-17 knockdown SK-Hep1 cells for studying the effects of IL-17 expression on the invasion and migration of human HCC cells in vitro by transwell assay and tumor angiogenesis in nude mouse. Immunohistochemistry was used to detect the expression of IL-17, E-cadherin, Vimentin and CD34 protein in 175 cases of human HCC tumor tissues. Kaplan-Meier was used to analyze the prognostic significance of TACE combined with apatinib treatment in HCC patients.

RESULTS

n SK-Hep1 cells, IL-17 knockdown could increase E-cadherin protein expression, reduce vimentin protein expression, inhibit cell invasion and migration in vitro, and inhibit angiogenesis of tumor and decrease plasma VEGF level in nude mouse. In tumor tissues of HCC patients, IL-17 protein expression was negatively correlated with E-cadherin protein expression (r = -0.622, P < 0.001), positively correlated with Vimentin protein expression (r = 0.540, P < 0.001), and was positively correlated with MVD of HCC tumor tissues (r = 0.564, P < 0.001). Compared with adjuvant TACE alone, patients with low-expression of IL-17 treated combined with apatinib have a higher 5-year overall survival. However, additional apatinib treatment did not significantly improve 5-year overall survival in HCC patients with high IL-17 expression.

CONCLUSION

IL-17 had a pivotal role in the invasion and angiogenesis of HCC and contribute to the selection of patients who may benefit from adjuvant TACE combined with apatinib.

Authors+Show Affiliations

Department of Radiology, Xiangyang central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.Department of Radiology, Xiangyang central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.Department of Radiology, Xiangyang central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.Department of Radiology, Xiangyang central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.Department of Radiology, Xiangyang central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.Department of Radiology, Xiangyang central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32651310

Citation

Wu, Yongjuan, et al. "IL-17 Predicts the Effect of TACE Combined With Apatinib in Hepatocellular Carcinoma." Clinical Hemorheology and Microcirculation, 2020.
Wu Y, Cheng G, Chen H, et al. IL-17 predicts the effect of TACE combined with apatinib in hepatocellular carcinoma. Clin Hemorheol Microcirc. 2020.
Wu, Y., Cheng, G., Chen, H., Wang, J., Wang, J., & Wang, W. (2020). IL-17 predicts the effect of TACE combined with apatinib in hepatocellular carcinoma. Clinical Hemorheology and Microcirculation. https://doi.org/10.3233/CH-200857
Wu Y, et al. IL-17 Predicts the Effect of TACE Combined With Apatinib in Hepatocellular Carcinoma. Clin Hemorheol Microcirc. 2020 Jul 9; PubMed PMID: 32651310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IL-17 predicts the effect of TACE combined with apatinib in hepatocellular carcinoma. AU - Wu,Yongjuan, AU - Cheng,Guangyuan, AU - Chen,Hui, AU - Wang,Jingzhong, AU - Wang,Jiangtao, AU - Wang,Wanbi, Y1 - 2020/07/09/ PY - 2020/7/12/entrez KW - IL-17 KW - hepatocellular carcinoma KW - overall survival KW - transcatheter arterial chemoembolization JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. N2 - OBJECTIVE: IL-17 is considered to be a cancer-promoting gene in hepatocellular carcinoma (HCC). Here, we explored the effect of IL-17 in predicting the therapeutic effect of transcatheter arterial chemoembolization (TACE) combined with apartinib in patients with HCC in this study. METHODS: Established of IL-17 knockdown SK-Hep1 cells for studying the effects of IL-17 expression on the invasion and migration of human HCC cells in vitro by transwell assay and tumor angiogenesis in nude mouse. Immunohistochemistry was used to detect the expression of IL-17, E-cadherin, Vimentin and CD34 protein in 175 cases of human HCC tumor tissues. Kaplan-Meier was used to analyze the prognostic significance of TACE combined with apatinib treatment in HCC patients. RESULTS: n SK-Hep1 cells, IL-17 knockdown could increase E-cadherin protein expression, reduce vimentin protein expression, inhibit cell invasion and migration in vitro, and inhibit angiogenesis of tumor and decrease plasma VEGF level in nude mouse. In tumor tissues of HCC patients, IL-17 protein expression was negatively correlated with E-cadherin protein expression (r = -0.622, P < 0.001), positively correlated with Vimentin protein expression (r = 0.540, P < 0.001), and was positively correlated with MVD of HCC tumor tissues (r = 0.564, P < 0.001). Compared with adjuvant TACE alone, patients with low-expression of IL-17 treated combined with apatinib have a higher 5-year overall survival. However, additional apatinib treatment did not significantly improve 5-year overall survival in HCC patients with high IL-17 expression. CONCLUSION: IL-17 had a pivotal role in the invasion and angiogenesis of HCC and contribute to the selection of patients who may benefit from adjuvant TACE combined with apatinib. SN - 1875-8622 UR - https://www.unboundmedicine.com/medline/citation/32651310/IL-17_predicts_the_effect_of_TACE_combined_with_apatinib_in_hepatocellular_carcinoma L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/CH-200857 DB - PRIME DP - Unbound Medicine ER -
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