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Reflux Hypersensitivity: How to Approach Diagnosis and Management.
Curr Gastroenterol Rep. 2020 Jul 10; 22(9):42.CG

Abstract

PURPOSE OF REVIEW

This paper aims to review the definition and diagnostic criteria for reflux hypersensitivity and comment on the present and future management of this condition.

RECENT FINDINGS

In 2016, the Rome IV criteria redefined reflux hypersensitivity as characterized by typical reflux symptoms, absence of endoscopic mucosal disease, absence of pathologic gastroesophageal reflux, and positive symptom correlation between reflux and heartburn episodes. Though uncertain, TPRV1 receptors have been implicated in the pathophysiology of reflux hypersensitivity. Recent studies have shown neuromodulators like SSRIs, SNRIs, and TCAs may be the future of managing this condition. With the release of the Rome IV criteria and availability of continuous pH monitoring, the diagnosis of reflux hypersensitivity has become more streamlined. Though there is no definitive therapy for reflux hypersensitivity, several anti-secretory agents and neuromodulators have shown some efficacy in therapeutic trials. The lack of large-scale, randomized controlled trials, however, reinforces the need for further research into the pharmacotherapy of reflux hypersensitivity.

Authors+Show Affiliations

University of Texas Health Science Center San Antonio, San Antonio, TX, USA.Division of Gastroenterology, Stanford University, 420 Broadway Street, Pavilion D, Redwood City, CA, 94063, USA. KamalA@stanford.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32651667

Citation

Aggarwal, Pankaj, and Afrin N. Kamal. "Reflux Hypersensitivity: How to Approach Diagnosis and Management." Current Gastroenterology Reports, vol. 22, no. 9, 2020, p. 42.
Aggarwal P, Kamal AN. Reflux Hypersensitivity: How to Approach Diagnosis and Management. Curr Gastroenterol Rep. 2020;22(9):42.
Aggarwal, P., & Kamal, A. N. (2020). Reflux Hypersensitivity: How to Approach Diagnosis and Management. Current Gastroenterology Reports, 22(9), 42. https://doi.org/10.1007/s11894-020-00779-x
Aggarwal P, Kamal AN. Reflux Hypersensitivity: How to Approach Diagnosis and Management. Curr Gastroenterol Rep. 2020 Jul 10;22(9):42. PubMed PMID: 32651667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reflux Hypersensitivity: How to Approach Diagnosis and Management. AU - Aggarwal,Pankaj, AU - Kamal,Afrin N, Y1 - 2020/07/10/ PY - 2020/7/12/entrez PY - 2020/7/12/pubmed PY - 2020/7/12/medline KW - Esophagus KW - Gastroesophageal reflux disease (GERD) KW - Heartburn KW - Hypersensitivity KW - Non-erosive reflux disease (NERD) KW - Reflux SP - 42 EP - 42 JF - Current gastroenterology reports JO - Curr Gastroenterol Rep VL - 22 IS - 9 N2 - PURPOSE OF REVIEW: This paper aims to review the definition and diagnostic criteria for reflux hypersensitivity and comment on the present and future management of this condition. RECENT FINDINGS: In 2016, the Rome IV criteria redefined reflux hypersensitivity as characterized by typical reflux symptoms, absence of endoscopic mucosal disease, absence of pathologic gastroesophageal reflux, and positive symptom correlation between reflux and heartburn episodes. Though uncertain, TPRV1 receptors have been implicated in the pathophysiology of reflux hypersensitivity. Recent studies have shown neuromodulators like SSRIs, SNRIs, and TCAs may be the future of managing this condition. With the release of the Rome IV criteria and availability of continuous pH monitoring, the diagnosis of reflux hypersensitivity has become more streamlined. Though there is no definitive therapy for reflux hypersensitivity, several anti-secretory agents and neuromodulators have shown some efficacy in therapeutic trials. The lack of large-scale, randomized controlled trials, however, reinforces the need for further research into the pharmacotherapy of reflux hypersensitivity. SN - 1534-312X UR - https://www.unboundmedicine.com/medline/citation/32651667/Reflux_Hypersensitivity:_How_to_Approach_Diagnosis_and_Management L2 - https://dx.doi.org/10.1007/s11894-020-00779-x DB - PRIME DP - Unbound Medicine ER -
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