TY - JOUR T1 - Infectivity, virulence, pathogenicity, host-pathogen interactions of SARS and SARS-CoV-2 in experimental animals: a systematic review. AU - Sarkar,Jayanta, AU - Guha,Rajdeep, Y1 - 2020/07/10/ PY - 2020/05/15/received PY - 2020/06/18/accepted PY - 2020/7/12/pubmed PY - 2020/10/24/medline PY - 2020/7/12/entrez KW - Coronaviruses KW - Non-human Primates KW - Rodents KW - SARS-CoV-2 KW - Transgenic Animals SP - 101 EP - 110 JF - Veterinary research communications JO - Vet Res Commun VL - 44 IS - 3-4 N2 - The outbreak of the SARS-CoV-2 in mainland China with subsequent human to human transmission worldwide had taken up the shape of a devastating pandemic. The ability of the virus to infect multiple species other than humans has currently been reported in experimental conditions. Non-human primates, felines, ferrets, rodents and host of other animals could previously be infected in experimental conditions with SARS-CoV and recently with SARS-CoV-2, both virus using Angiotensin-converting-enzyme 2 receptor for cellular entry. The variations in sequence homology of ACE2 receptor across species is identified as one of the factors determining virulence and pathogenicity in animals. The infection in experimental animals with SARS-CoV or SARS-CoV-2 on most occasions are asymptomatic, however, the virus could multiply within the respiratory tract and extra-pulmonary organs in most of the species. Here, we discuss about the pathogenicity, transmission, variations in angiotensin-converting-enzyme 2 receptor-binding across species and host pathogen interactions of SARS and SARS-CoV-2 in laboratory animals used in research. SN - 1573-7446 UR - https://www.unboundmedicine.com/medline/citation/32651761/Infectivity_virulence_pathogenicity_host_pathogen_interactions_of_SARS_and_SARS_CoV_2_in_experimental_animals:_a_systematic_review_ DB - PRIME DP - Unbound Medicine ER -