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Endocrine Significance of SARS-CoV-2's Reliance on ACE2.
Endocrinology. 2020 09 01; 161(9)E

Abstract

The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.

Authors+Show Affiliations

Department of Pharmacology & Experimental Therapeutics, New Orleans, Louisiana. Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Southeast Louisiana Veterans Health Care Systems, New Orleans, Louisiana.Southeast Louisiana Veterans Health Care Systems, New Orleans, Louisiana. Division of Endocrinology & Metabolism, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.Southeast Louisiana Veterans Health Care Systems, New Orleans, Louisiana. Division of Endocrinology & Metabolism, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32652001

Citation

Lazartigues, Eric, et al. "Endocrine Significance of SARS-CoV-2's Reliance On ACE2." Endocrinology, vol. 161, no. 9, 2020.
Lazartigues E, Qadir MMF, Mauvais-Jarvis F. Endocrine Significance of SARS-CoV-2's Reliance on ACE2. Endocrinology. 2020;161(9).
Lazartigues, E., Qadir, M. M. F., & Mauvais-Jarvis, F. (2020). Endocrine Significance of SARS-CoV-2's Reliance on ACE2. Endocrinology, 161(9). https://doi.org/10.1210/endocr/bqaa108
Lazartigues E, Qadir MMF, Mauvais-Jarvis F. Endocrine Significance of SARS-CoV-2's Reliance On ACE2. Endocrinology. 2020 09 1;161(9) PubMed PMID: 32652001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine Significance of SARS-CoV-2's Reliance on ACE2. AU - Lazartigues,Eric, AU - Qadir,Mirza Muhammad Fahd, AU - Mauvais-Jarvis,Franck, PY - 2020/06/08/received PY - 2020/06/24/accepted PY - 2020/7/12/pubmed PY - 2020/9/9/medline PY - 2020/7/12/entrez KW - ACE2 KW - COVID-19 KW - SARS-CoV-2 KW - TMPRSS-2 KW - diabetes KW - renin-angiotensin system JF - Endocrinology JO - Endocrinology VL - 161 IS - 9 N2 - The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases. SN - 1945-7170 UR - https://www.unboundmedicine.com/medline/citation/32652001/Endocrine_Significance_of_SARS_CoV_2's_Reliance_on_ACE2_ L2 - https://academic.oup.com/endo/article-lookup/doi/10.1210/endocr/bqaa108 DB - PRIME DP - Unbound Medicine ER -