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Update on neurological manifestations of COVID-19.
Life Sci. 2020 Sep 15; 257:118063.LS

Abstract

Novel coronavirus (severe acute respiratory syndrome coronavirus-2: SARS-CoV-2) has a high homology with other cousin of coronaviruses such as SARS and Middle East respiratory syndrome-related coronavirus (MERS). After outbreak of the SARS-CoV-2 in China, it has spread so fast around the world. The main complication of coronavirus disease 2019 (COVID-19) is respiratory failure, but several patients have also been admitted to the hospital with neurological symptoms. Direct invasion, hematogenic rout, retrograde and anterograde transport along peripheral nerves are considered as main neuroinvasion mechanisms of SARS-CoV-2. In the present study, we describe the possible routes for entering of SARS-CoV-2 into the nervous system. Then, the neurological manifestations of the SARS-CoV-2 infection in the central nervous system (CNS) and peripheral nervous system (PNS) are reviewed. Furthermore, the neuropathology of the virus and its impacts on other neurological disorders are discussed.

Authors+Show Affiliations

Student Research Committee, Babol University of Medical Sciences, Babol, Iran.Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address: m.ghasemi@mubabol.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32652139

Citation

Yavarpour-Bali, Hanie, and Maryam Ghasemi-Kasman. "Update On Neurological Manifestations of COVID-19." Life Sciences, vol. 257, 2020, p. 118063.
Yavarpour-Bali H, Ghasemi-Kasman M. Update on neurological manifestations of COVID-19. Life Sci. 2020;257:118063.
Yavarpour-Bali, H., & Ghasemi-Kasman, M. (2020). Update on neurological manifestations of COVID-19. Life Sciences, 257, 118063. https://doi.org/10.1016/j.lfs.2020.118063
Yavarpour-Bali H, Ghasemi-Kasman M. Update On Neurological Manifestations of COVID-19. Life Sci. 2020 Sep 15;257:118063. PubMed PMID: 32652139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Update on neurological manifestations of COVID-19. AU - Yavarpour-Bali,Hanie, AU - Ghasemi-Kasman,Maryam, Y1 - 2020/07/09/ PY - 2020/05/29/received PY - 2020/07/03/revised PY - 2020/07/05/accepted PY - 2020/7/12/pubmed PY - 2020/9/30/medline PY - 2020/7/12/entrez KW - Nervous system KW - Neuroinvasion KW - Neurological symptoms KW - Novel coronavirus SP - 118063 EP - 118063 JF - Life sciences JO - Life Sci VL - 257 N2 - Novel coronavirus (severe acute respiratory syndrome coronavirus-2: SARS-CoV-2) has a high homology with other cousin of coronaviruses such as SARS and Middle East respiratory syndrome-related coronavirus (MERS). After outbreak of the SARS-CoV-2 in China, it has spread so fast around the world. The main complication of coronavirus disease 2019 (COVID-19) is respiratory failure, but several patients have also been admitted to the hospital with neurological symptoms. Direct invasion, hematogenic rout, retrograde and anterograde transport along peripheral nerves are considered as main neuroinvasion mechanisms of SARS-CoV-2. In the present study, we describe the possible routes for entering of SARS-CoV-2 into the nervous system. Then, the neurological manifestations of the SARS-CoV-2 infection in the central nervous system (CNS) and peripheral nervous system (PNS) are reviewed. Furthermore, the neuropathology of the virus and its impacts on other neurological disorders are discussed. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/32652139/Update_on_neurological_manifestations_of_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(20)30814-6 DB - PRIME DP - Unbound Medicine ER -