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The Cerebellar Nuclei and Dexterous Limb Movements.
Neuroscience. 2020 Jul 09 [Online ahead of print]N

Abstract

Dexterous forelimb movements like reaching, grasping, and manipulating objects are fundamental building blocks of the mammalian motor repertoire. These behaviors are essential to everyday activities, and their elaboration underlies incredible accomplishments by human beings in art and sport. Moreover, the susceptibility of these behaviors to damage and disease of the nervous system can lead to debilitating deficits, highlighting a need for a better understanding of function and dysfunction in sensorimotor control. The cerebellum is central to coordinating limb movements, as defined in large part by Joseph Babinski and Gordon Holmes describing motor impairment in patients with cerebellar lesions over 100 years ago (Babinski, 1902; Holmes, 1917), and supported by many important human and animal studies that have been conducted since. Here, with a focus on output pathways of the cerebellar nuclei across mammalian species, we describe forelimb movement deficits observed when cerebellar circuits are perturbed, the mechanisms through which these circuits influence motor output, and key challenges in defining how the cerebellum refines limb movement.

Authors+Show Affiliations

Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.Nanyang Technological University (NTU), School of Biological Sciences, 11 Mandalay Road, Singapore 308232, Singapore; A*STAR, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 308232, Singapore. Electronic address: albert.chen@ntu.edu.sg.Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: eazim@salk.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32652173

Citation

Thanawalla, Ayesha R., et al. "The Cerebellar Nuclei and Dexterous Limb Movements." Neuroscience, 2020.
Thanawalla AR, Chen AI, Azim E. The Cerebellar Nuclei and Dexterous Limb Movements. Neuroscience. 2020.
Thanawalla, A. R., Chen, A. I., & Azim, E. (2020). The Cerebellar Nuclei and Dexterous Limb Movements. Neuroscience. https://doi.org/10.1016/j.neuroscience.2020.06.046
Thanawalla AR, Chen AI, Azim E. The Cerebellar Nuclei and Dexterous Limb Movements. Neuroscience. 2020 Jul 9; PubMed PMID: 32652173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Cerebellar Nuclei and Dexterous Limb Movements. AU - Thanawalla,Ayesha R, AU - Chen,Albert I, AU - Azim,Eiman, Y1 - 2020/07/09/ PY - 2020/02/22/received PY - 2020/06/03/revised PY - 2020/06/30/accepted PY - 2020/7/12/pubmed PY - 2020/7/12/medline PY - 2020/7/12/entrez KW - Ataxia KW - Cerebellar nuclei KW - Dysmetria KW - Grasp KW - Internal copy KW - Reach JF - Neuroscience JO - Neuroscience N2 - Dexterous forelimb movements like reaching, grasping, and manipulating objects are fundamental building blocks of the mammalian motor repertoire. These behaviors are essential to everyday activities, and their elaboration underlies incredible accomplishments by human beings in art and sport. Moreover, the susceptibility of these behaviors to damage and disease of the nervous system can lead to debilitating deficits, highlighting a need for a better understanding of function and dysfunction in sensorimotor control. The cerebellum is central to coordinating limb movements, as defined in large part by Joseph Babinski and Gordon Holmes describing motor impairment in patients with cerebellar lesions over 100 years ago (Babinski, 1902; Holmes, 1917), and supported by many important human and animal studies that have been conducted since. Here, with a focus on output pathways of the cerebellar nuclei across mammalian species, we describe forelimb movement deficits observed when cerebellar circuits are perturbed, the mechanisms through which these circuits influence motor output, and key challenges in defining how the cerebellum refines limb movement. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/32652173/The_cerebellar_nuclei_and_dexterous_limb_movements L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(20)30427-9 DB - PRIME DP - Unbound Medicine ER -
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