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Corneal biomechanical properties in myopic eyes evaluated via Scheimpflug imaging.
BMC Ophthalmol. 2020 Jul 11; 20(1):279.BO

Abstract

BACKGROUND

To investigate the biomechanical properties of the cornea in myopic eyes using corneal visualization Scheimpflug technology (Corvis ST). The relationships between the biomechanical properties of the cornea and the degree of myopia were also investigated.

METHODS

265 eyes of 265 subjects were included. Based on spherical equivalent (SE) in diopters (D), participants were divided into four groups: low myopia/control (SE: - 0.50 to - 3.00D), moderate myopia (SE: - 3.00 to - 6.00D), high myopia (SE: - 6.00 to - 10.00D) and severe myopia (SE greater than - 10.00D). Axial length (AL), anterior segment parameters, and corneal biomechanical properties were obtained with the Lenstar LS900, Pentacam HR and Corvis ST, respectively.

RESULTS

Mean (±SD) SE was - 7.29 ± 4.31D (range: - 0.63 to - 25.75D). Mean AL was 26.31 ± 1.82 mm (range: 21.87 to 31.94 mm). Significant differences were detected within the four groups in terms of six corneal biomechanical parameters: deformation amplitude (DA), time from start until second applanation (A2-time), length of flattened cornea at the second applanation (A2-length), corneal velocity during the first and second applanation (A2-velocity), time from start to highest concavity (HC-time), and central curvature at highest concavity (HC radius). AL was positively associated with DA whereas negatively associated with A1-velocity and A2-length. SE was positively associated with A2-time, HC-time and A2-velocity, whereas negatively associated with DA. IOP was positively associated with four corneal biomechanical parameters and negatively associated with three parameters.

CONCLUSIONS

Eyes with severe myopia showed greater DA, lesser A2 time, HC time, and faster A2-velocity compared to low to high myopia. This suggests the cornea becomes weaker and more deformable with elongation of axial length with corresponding increases in myopia. DA, A2-time and A2-velocity could be useful corneal biomechanical indicators in patients with myopia.

Authors+Show Affiliations

School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, Zhejiang, China.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, Zhejiang, China.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, Zhejiang, China.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. Department of Ophthalmology, Singleton Hospital, Swansea Bay University Health Board, Swansea, UK.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. vip999vip@163.com. Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, Zhejiang, China. vip999vip@163.com. Eye Hospital of Wenzhou Medical University, 270 West Xueyuan Road, Wenzhou, Zhejiang, 325027, China. vip999vip@163.com.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. 248111700@qq.com. Key Laboratory of Vision Science, Ministry of Health Peoples Republic of China, Wenzhou, Zhejiang, China. 248111700@qq.com. Eye Hospital of Wenzhou Medical University, 270 West Xueyuan Road, Wenzhou, Zhejiang, 325027, China. 248111700@qq.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32652982

Citation

Yu, A-Yong, et al. "Corneal Biomechanical Properties in Myopic Eyes Evaluated Via Scheimpflug Imaging." BMC Ophthalmology, vol. 20, no. 1, 2020, p. 279.
Yu AY, Shao H, Pan A, et al. Corneal biomechanical properties in myopic eyes evaluated via Scheimpflug imaging. BMC Ophthalmol. 2020;20(1):279.
Yu, A. Y., Shao, H., Pan, A., Wang, Q., Huang, Z., Song, B., McAlinden, C., Huang, J., & Chen, S. (2020). Corneal biomechanical properties in myopic eyes evaluated via Scheimpflug imaging. BMC Ophthalmology, 20(1), 279. https://doi.org/10.1186/s12886-020-01530-w
Yu AY, et al. Corneal Biomechanical Properties in Myopic Eyes Evaluated Via Scheimpflug Imaging. BMC Ophthalmol. 2020 Jul 11;20(1):279. PubMed PMID: 32652982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corneal biomechanical properties in myopic eyes evaluated via Scheimpflug imaging. AU - Yu,A-Yong, AU - Shao,Hui, AU - Pan,Anpeng, AU - Wang,Qinmei, AU - Huang,Zixu, AU - Song,Benhao, AU - McAlinden,Colm, AU - Huang,Jinhai, AU - Chen,Sisi, Y1 - 2020/07/11/ PY - 2020/03/18/received PY - 2020/06/26/accepted PY - 2020/7/13/entrez PY - 2020/7/13/pubmed PY - 2020/7/13/medline KW - Corneal biomechanics KW - Corvis ST KW - Myopia KW - Scheimpflug SP - 279 EP - 279 JF - BMC ophthalmology JO - BMC Ophthalmol VL - 20 IS - 1 N2 - BACKGROUND: To investigate the biomechanical properties of the cornea in myopic eyes using corneal visualization Scheimpflug technology (Corvis ST). The relationships between the biomechanical properties of the cornea and the degree of myopia were also investigated. METHODS: 265 eyes of 265 subjects were included. Based on spherical equivalent (SE) in diopters (D), participants were divided into four groups: low myopia/control (SE: - 0.50 to - 3.00D), moderate myopia (SE: - 3.00 to - 6.00D), high myopia (SE: - 6.00 to - 10.00D) and severe myopia (SE greater than - 10.00D). Axial length (AL), anterior segment parameters, and corneal biomechanical properties were obtained with the Lenstar LS900, Pentacam HR and Corvis ST, respectively. RESULTS: Mean (±SD) SE was - 7.29 ± 4.31D (range: - 0.63 to - 25.75D). Mean AL was 26.31 ± 1.82 mm (range: 21.87 to 31.94 mm). Significant differences were detected within the four groups in terms of six corneal biomechanical parameters: deformation amplitude (DA), time from start until second applanation (A2-time), length of flattened cornea at the second applanation (A2-length), corneal velocity during the first and second applanation (A2-velocity), time from start to highest concavity (HC-time), and central curvature at highest concavity (HC radius). AL was positively associated with DA whereas negatively associated with A1-velocity and A2-length. SE was positively associated with A2-time, HC-time and A2-velocity, whereas negatively associated with DA. IOP was positively associated with four corneal biomechanical parameters and negatively associated with three parameters. CONCLUSIONS: Eyes with severe myopia showed greater DA, lesser A2 time, HC time, and faster A2-velocity compared to low to high myopia. This suggests the cornea becomes weaker and more deformable with elongation of axial length with corresponding increases in myopia. DA, A2-time and A2-velocity could be useful corneal biomechanical indicators in patients with myopia. SN - 1471-2415 UR - https://www.unboundmedicine.com/medline/citation/32652982/Corneal_biomechanical_properties_in_myopic_eyes_evaluated_via_Scheimpflug_imaging L2 - https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01530-w DB - PRIME DP - Unbound Medicine ER -
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