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The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions.
Life Sci. 2020 Sep 15; 257:118075.LS

Abstract

The novel corona virus disease has shaken the entire world with its deadly effects and rapid transmission rates, posing a significant challenge to the healthcare authorities to develop suitable therapeutic solution to save lives on earth. The review aims to grab the attention of the researchers all over the globe, towards the role of ACE2 in COVID-19 disease. ACE2 serves as a molecular target for the SARS-CoV-2, to enter the target cell, by interacting with the viral glycoprotein spikes. However, the complexity began when numerous studies identified the protective response of ACE2 in abbreviating the harmful effects of vasoconstrictor, anti-inflammatory peptide, angiotensin 2, by mediating its conversion to angiotensin-(1-7), which exercised antagonistic actions to angiotensin 2. Furthermore, certain investigations revealed greater resistance among children as compared to the geriatrics, towards COVID-19 infection, despite the elevated expression of ACE2 in pediatric population. Based upon such evidences, the review demonstrated possible therapeutic interventions, targeting both the protective and deleterious effects of ACE2 in COVID-19 disease, primarily inhibiting ACE2-virus interactions or administering soluble ACE2. Thus, the authors aim to provide an opportunity for the researchers to consider RAAS system to be a significant element in development of suitable treatment regime for COVID-19 pandemic.

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Authors+Show Affiliations

Behl T
Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India. Electronic address: tapanbehl31@gmail.com.
Kaur I
Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India.
Bungau S
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Romania. Electronic address: sbungau@uoradea.ro.
Kumar A
Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India.
Uddin MS
Department of Pharmacy, Southeast University, 1213 Dhaka, Bangladesh; Pharmakon Neuroscience Research Network, Dhaka, Bangladesh.
Kumar C
Department of Medical Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Pal G
Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, 110007 Delhi, India.
Sahil
Department of Computer Science, Panjab University, Chandigarh, India.
Shrivastava K
Department of Medical Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Zengin G
Selcuk University, Selçuklu, Konya, Turkey.
Arora S
Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India.

MeSH

Age FactorsAgedAged, 80 and overAngiotensin-Converting Enzyme 2Anti-Inflammatory AgentsBetacoronavirusCOVID-19ChildChild, PreschoolCoronavirusCoronavirus InfectionsFemaleGeriatricsHumansInfantInfant, NewbornMalePandemicsPediatricsPeptidyl-Dipeptidase APneumonia, ViralProtein BindingReceptors, VirusRenin-Angiotensin SystemSARS-CoV-2Severe Acute Respiratory SyndromeVirus Internalization

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32653522

Citation

Behl, Tapan, et al. "The Dual Impact of ACE2 in COVID-19 and Ironical Actions in Geriatrics and Pediatrics With Possible Therapeutic Solutions." Life Sciences, vol. 257, 2020, p. 118075.
Behl T, Kaur I, Bungau S, et al. The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. Life Sci. 2020;257:118075.
Behl, T., Kaur, I., Bungau, S., Kumar, A., Uddin, M. S., Kumar, C., Pal, G., Sahil, ., Shrivastava, K., Zengin, G., & Arora, S. (2020). The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. Life Sciences, 257, 118075. https://doi.org/10.1016/j.lfs.2020.118075
Behl T, et al. The Dual Impact of ACE2 in COVID-19 and Ironical Actions in Geriatrics and Pediatrics With Possible Therapeutic Solutions. Life Sci. 2020 Sep 15;257:118075. PubMed PMID: 32653522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. AU - Behl,Tapan, AU - Kaur,Ishnoor, AU - Bungau,Simona, AU - Kumar,Arun, AU - Uddin,Md Sahab, AU - Kumar,Chanchal, AU - Pal,Giridhari, AU - Sahil,, AU - Shrivastava,Kamal, AU - Zengin,Gokhan, AU - Arora,Sandeep, Y1 - 2020/07/10/ PY - 2020/06/20/received PY - 2020/07/05/revised PY - 2020/07/06/accepted PY - 2020/7/13/pubmed PY - 2020/9/30/medline PY - 2020/7/13/entrez KW - ACE2 KW - Angiotensin 2 KW - Angiotensin-(1–7) KW - Corona virus KW - Glycoprotein spikes KW - RAAS system SP - 118075 EP - 118075 JF - Life sciences JO - Life Sci VL - 257 N2 - The novel corona virus disease has shaken the entire world with its deadly effects and rapid transmission rates, posing a significant challenge to the healthcare authorities to develop suitable therapeutic solution to save lives on earth. The review aims to grab the attention of the researchers all over the globe, towards the role of ACE2 in COVID-19 disease. ACE2 serves as a molecular target for the SARS-CoV-2, to enter the target cell, by interacting with the viral glycoprotein spikes. However, the complexity began when numerous studies identified the protective response of ACE2 in abbreviating the harmful effects of vasoconstrictor, anti-inflammatory peptide, angiotensin 2, by mediating its conversion to angiotensin-(1-7), which exercised antagonistic actions to angiotensin 2. Furthermore, certain investigations revealed greater resistance among children as compared to the geriatrics, towards COVID-19 infection, despite the elevated expression of ACE2 in pediatric population. Based upon such evidences, the review demonstrated possible therapeutic interventions, targeting both the protective and deleterious effects of ACE2 in COVID-19 disease, primarily inhibiting ACE2-virus interactions or administering soluble ACE2. Thus, the authors aim to provide an opportunity for the researchers to consider RAAS system to be a significant element in development of suitable treatment regime for COVID-19 pandemic. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/32653522/The_dual_impact_of_ACE2_in_COVID_19_and_ironical_actions_in_geriatrics_and_pediatrics_with_possible_therapeutic_solutions_ DB - PRIME DP - Unbound Medicine ER -