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Maternal and childhood urinary phenol concentrations, neonatal thyroid function, and behavioral problems at 10 years of age: The SMBCS study.
Sci Total Environ. 2020 Jul 06; 743:140678.ST

Abstract

BACKGROUND

Environmental phenols, bisphenol A (BPA), triclosan (TCS), and benzophenone-3 (BP-3), are known as emerging endocrine-disrupting chemicals; however, their impacts on thyroid hormones and children's neurobehaviors are still unclear.

OBJECTIVES

We aimed to examine the associations of prenatal and childhood exposure to phenols with neonatal thyroid function and childhood behavioral problems aged 10 years.

METHODS

A total of 386 mother-singleton pairs were included from Sheyang Mini Birth Cohort Study (SMBCS), a longitudinal birth cohort in China. We quantified urinary BPA, TCS and BP-3 concentrations in maternal and 10-year-old children's urine samples using gas chromatography tandem mass spectrometry and thyroid function parameters in cord serum samples. Caregivers completed the Strength and Difficulties Questionnaire (SDQ) for their children at 10 years of age. Multivariable linear regression models and logistic regression models were applied to estimate associations of urinary phenol concentrations with thyroid hormones and risks of children's behavioral problems, respectively.

RESULTS

The median values of urinary BPA, TCS and BP-3 concentrations for pregnant women were 1.75 μg/L, 0.54 μg/L and 0.37 μg/L, while 1.29 μg/L, 6.64 μg/L and 1.39 μg/L for children, respectively. Maternal urinary BPA concentrations were in associations with 1.00% [95% confidence interval (CI): 0.20%, 1.92%] increases in cord serum FT4 concentrations and significantly associated with increased risks of total difficulties [odds ratio (OR): 1.45, 95% CI: 1.07, 1.97], while maternal urinary levels of BP-3 were significantly related to poorer prosocial behaviors (OR: 1.58, 95% CI: 1.04, 2.39) of children at 10 years of age. In sex-stratified analyses, maternal urinary BPA concentrations were related to increased total difficulty subscales only in boys.

CONCLUSIONS

The findings indicated that higher prenatal urinary BPA concentrations were associated with increased risks of total difficulties, especially in boys and maternal urinary BP-3 concentrations were related to poorer prosocial behaviors at 10 years.

Authors+Show Affiliations

School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China. Electronic address: chwu@shmu.edu.cn.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai 200336, China.Zhejiang Provincial Center for Disease Control and Prevention, No. 3399 Binsheng Road, Hangzhou 310051, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai 200336, China.Changning District Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai 200051, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.Changning District Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai 200051, China.Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro 70182, Sweden.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai 200336, China.School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China. Electronic address: zjzhou@fudan.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32653713

Citation

Guo, Jianqiu, et al. "Maternal and Childhood Urinary Phenol Concentrations, Neonatal Thyroid Function, and Behavioral Problems at 10 Years of Age: the SMBCS Study." The Science of the Total Environment, vol. 743, 2020, p. 140678.
Guo J, Wu C, Zhang J, et al. Maternal and childhood urinary phenol concentrations, neonatal thyroid function, and behavioral problems at 10 years of age: The SMBCS study. Sci Total Environ. 2020;743:140678.
Guo, J., Wu, C., Zhang, J., Li, W., Lv, S., Lu, D., Qi, X., Feng, C., Liang, W., Chang, X., Zhang, Y., Xu, H., Cao, Y., Wang, G., & Zhou, Z. (2020). Maternal and childhood urinary phenol concentrations, neonatal thyroid function, and behavioral problems at 10 years of age: The SMBCS study. The Science of the Total Environment, 743, 140678. https://doi.org/10.1016/j.scitotenv.2020.140678
Guo J, et al. Maternal and Childhood Urinary Phenol Concentrations, Neonatal Thyroid Function, and Behavioral Problems at 10 Years of Age: the SMBCS Study. Sci Total Environ. 2020 Jul 6;743:140678. PubMed PMID: 32653713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal and childhood urinary phenol concentrations, neonatal thyroid function, and behavioral problems at 10 years of age: The SMBCS study. AU - Guo,Jianqiu, AU - Wu,Chunhua, AU - Zhang,Jiming, AU - Li,Wenting, AU - Lv,Shenliang, AU - Lu,Dasheng, AU - Qi,Xiaojuan, AU - Feng,Chao, AU - Liang,Weijiu, AU - Chang,Xiuli, AU - Zhang,Yubin, AU - Xu,Hao, AU - Cao,Yang, AU - Wang,Guoquan, AU - Zhou,Zhijun, Y1 - 2020/07/06/ PY - 2020/04/12/received PY - 2020/06/15/revised PY - 2020/06/30/accepted PY - 2020/7/13/pubmed PY - 2020/7/13/medline PY - 2020/7/13/entrez KW - Behavioral problems KW - Benzophenone-3 KW - Bisphenol A KW - Prenatal and postnatal exposure KW - Triclosan SP - 140678 EP - 140678 JF - The Science of the total environment JO - Sci. Total Environ. VL - 743 N2 - BACKGROUND: Environmental phenols, bisphenol A (BPA), triclosan (TCS), and benzophenone-3 (BP-3), are known as emerging endocrine-disrupting chemicals; however, their impacts on thyroid hormones and children's neurobehaviors are still unclear. OBJECTIVES: We aimed to examine the associations of prenatal and childhood exposure to phenols with neonatal thyroid function and childhood behavioral problems aged 10 years. METHODS: A total of 386 mother-singleton pairs were included from Sheyang Mini Birth Cohort Study (SMBCS), a longitudinal birth cohort in China. We quantified urinary BPA, TCS and BP-3 concentrations in maternal and 10-year-old children's urine samples using gas chromatography tandem mass spectrometry and thyroid function parameters in cord serum samples. Caregivers completed the Strength and Difficulties Questionnaire (SDQ) for their children at 10 years of age. Multivariable linear regression models and logistic regression models were applied to estimate associations of urinary phenol concentrations with thyroid hormones and risks of children's behavioral problems, respectively. RESULTS: The median values of urinary BPA, TCS and BP-3 concentrations for pregnant women were 1.75 μg/L, 0.54 μg/L and 0.37 μg/L, while 1.29 μg/L, 6.64 μg/L and 1.39 μg/L for children, respectively. Maternal urinary BPA concentrations were in associations with 1.00% [95% confidence interval (CI): 0.20%, 1.92%] increases in cord serum FT4 concentrations and significantly associated with increased risks of total difficulties [odds ratio (OR): 1.45, 95% CI: 1.07, 1.97], while maternal urinary levels of BP-3 were significantly related to poorer prosocial behaviors (OR: 1.58, 95% CI: 1.04, 2.39) of children at 10 years of age. In sex-stratified analyses, maternal urinary BPA concentrations were related to increased total difficulty subscales only in boys. CONCLUSIONS: The findings indicated that higher prenatal urinary BPA concentrations were associated with increased risks of total difficulties, especially in boys and maternal urinary BP-3 concentrations were related to poorer prosocial behaviors at 10 years. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/32653713/Maternal_and_childhood_urinary_phenol_concentrations,_neonatal_thyroid_function,_and_behavioral_problems_at_10 years_of_age:_The_SMBCS_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(20)34200-5 DB - PRIME DP - Unbound Medicine ER -
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