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A Comparative Study to Assess the Efficacy of Fractional Carbon Dioxide Laser and Combination of Fractional Carbon Dioxide Laser with Topical Autologous Platelet-rich Plasma in Post-acne Atrophic Scars.
J Cutan Aesthet Surg. 2019 Jan-Mar; 13(1):11-17.JC

Abstract

Context

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit prevalent in adolescent population. Atrophic acne scarring negatively affects the quality of life. Although challenging to treat, the introduction of fractional carbon dioxide (CO2) laser and platelet-rich plasma (PRP) therapy for atrophic scars has opened up new avenues.

Aim

The aim of this study was to evaluate and compare the efficacy of fractional CO2 laser alone and in combination with topical PRP in treating post-acne atrophic scars.

Subjects and Methods

A hospital-based prospective, double-blinded, randomized, and comparative study was conducted. A total of 33 cases with post-acne atrophic scars of moderate to severe grade were randomly allotted into Group A and Group B who were treated for three monthly sessions of fractional CO2 laser followed by topical PRP and fractional CO2 laser monotherapy, respectively. Evaluation at baseline and every visit was carried out and compared at the end of 12 weeks.

Results

Of the 33 patients, 25 completed the study. The mean change in score was higher in subjects of Group A. The mean scar score significantly reduced in both groups. The mean visual analog scale was higher in Group A. The reduction in scar score was significantly higher in patients with rolling scars and boxcar scars and least in ice pick scars. Erythema, edema, pain, and hyperpigmentation were higher in Group B.

Conclusion

Combination therapy with PRP is more efficacious in reducing post-acne atrophic scars and reducing adverse effects of laser therapy as compared to fractional CO2 laser monotherapy.

Authors+Show Affiliations

Department of Dermatology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Bijapur, Karnataka, India.Department of Dermatology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Bijapur, Karnataka, India.Department of Dermatology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Bijapur, Karnataka, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32655245

Citation

Arsiwala, Nazneen Z., et al. "A Comparative Study to Assess the Efficacy of Fractional Carbon Dioxide Laser and Combination of Fractional Carbon Dioxide Laser With Topical Autologous Platelet-rich Plasma in Post-acne Atrophic Scars." Journal of Cutaneous and Aesthetic Surgery, vol. 13, no. 1, 2019, pp. 11-17.
Arsiwala NZ, Inamadar AC, Adya KA. A Comparative Study to Assess the Efficacy of Fractional Carbon Dioxide Laser and Combination of Fractional Carbon Dioxide Laser with Topical Autologous Platelet-rich Plasma in Post-acne Atrophic Scars. J Cutan Aesthet Surg. 2019;13(1):11-17.
Arsiwala, N. Z., Inamadar, A. C., & Adya, K. A. (2019). A Comparative Study to Assess the Efficacy of Fractional Carbon Dioxide Laser and Combination of Fractional Carbon Dioxide Laser with Topical Autologous Platelet-rich Plasma in Post-acne Atrophic Scars. Journal of Cutaneous and Aesthetic Surgery, 13(1), 11-17. https://doi.org/10.4103/JCAS.JCAS_142_19
Arsiwala NZ, Inamadar AC, Adya KA. A Comparative Study to Assess the Efficacy of Fractional Carbon Dioxide Laser and Combination of Fractional Carbon Dioxide Laser With Topical Autologous Platelet-rich Plasma in Post-acne Atrophic Scars. J Cutan Aesthet Surg. 2019 Jan-Mar;13(1):11-17. PubMed PMID: 32655245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Comparative Study to Assess the Efficacy of Fractional Carbon Dioxide Laser and Combination of Fractional Carbon Dioxide Laser with Topical Autologous Platelet-rich Plasma in Post-acne Atrophic Scars. AU - Arsiwala,Nazneen Z, AU - Inamadar,Arun C, AU - Adya,Keshavmurthy A, PY - 2020/7/14/entrez PY - 2019/1/1/pubmed PY - 2019/1/1/medline KW - Fractional carbon dioxide laser KW - platelet-rich plasma KW - post-acne atrophic scars SP - 11 EP - 17 JF - Journal of cutaneous and aesthetic surgery JO - J Cutan Aesthet Surg VL - 13 IS - 1 N2 - Context: Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit prevalent in adolescent population. Atrophic acne scarring negatively affects the quality of life. Although challenging to treat, the introduction of fractional carbon dioxide (CO2) laser and platelet-rich plasma (PRP) therapy for atrophic scars has opened up new avenues. Aim: The aim of this study was to evaluate and compare the efficacy of fractional CO2 laser alone and in combination with topical PRP in treating post-acne atrophic scars. Subjects and Methods: A hospital-based prospective, double-blinded, randomized, and comparative study was conducted. A total of 33 cases with post-acne atrophic scars of moderate to severe grade were randomly allotted into Group A and Group B who were treated for three monthly sessions of fractional CO2 laser followed by topical PRP and fractional CO2 laser monotherapy, respectively. Evaluation at baseline and every visit was carried out and compared at the end of 12 weeks. Results: Of the 33 patients, 25 completed the study. The mean change in score was higher in subjects of Group A. The mean scar score significantly reduced in both groups. The mean visual analog scale was higher in Group A. The reduction in scar score was significantly higher in patients with rolling scars and boxcar scars and least in ice pick scars. Erythema, edema, pain, and hyperpigmentation were higher in Group B. Conclusion: Combination therapy with PRP is more efficacious in reducing post-acne atrophic scars and reducing adverse effects of laser therapy as compared to fractional CO2 laser monotherapy. SN - 0974-2077 UR - https://www.unboundmedicine.com/medline/citation/32655245/A_Comparative_Study_to_Assess_the_Efficacy_of_Fractional_Carbon_Dioxide_Laser_and_Combination_of_Fractional_Carbon_Dioxide_Laser_with_Topical_Autologous_Platelet_rich_Plasma_in_Post_acne_Atrophic_Scars_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32655245/ DB - PRIME DP - Unbound Medicine ER -
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