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Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals.
Ocul Immunol Inflamm. 2020 Oct 02; 28(7):1040-1048.OI

Abstract

Syphilis and HIV infection may coexist in the same individual. Ocular syphilis and/or neurosyphilis may develop at any stage of coinfection, with a stronger association between ocular and neurosyphilis in individuals living with HIV, than in HIV-uninfected individuals. The diagnosis of ocular syphilis in HIV-infected and -uninfected patients remains with some controversy due to unspecific clinical manifestations and limited diagnostic tests. Penicillin is the mainstay of treatment of ocular syphilis, but alternative options are warranted. This review describes the epidemiology, pathophysiology, and clinical manifestations, as well as the diagnostic and therapeutic challenges posed by ocular syphilis against the background of HIV coinfection.

Authors+Show Affiliations

Department of Ophthalmology and Otolaryngology, Faculdade de Medicina da Universidade Federal de Minas Gerais , Belo Horizonte, Brazil. Uveitis Unit, Hospital São Geraldo/Hospital das Clínicas da Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.Division of Ophthalmology, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town, South Africa.Foundation for Professional Development, Research Unit , East London, South Africa. Department of Medical Microbiology, University of Pretoria , Pretoria, South Africa. CAPHRI School of Public Health & Primary Care, Maastricht University Medical Centre , Maastricht, The Netherlands.Department of Ophthalmology and Otolaryngology, Faculdade de Medicina da Universidade Federal de Minas Gerais , Belo Horizonte, Brazil. Uveitis Unit, Hospital São Geraldo/Hospital das Clínicas da Universidade Federal de Minas Gerais , Belo Horizonte, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32657637

Citation

Queiroz, Rafael de Pinho, et al. "Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals." Ocular Immunology and Inflammation, vol. 28, no. 7, 2020, pp. 1040-1048.
Queiroz RP, Smit DP, Peters RPH, et al. Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals. Ocul Immunol Inflamm. 2020;28(7):1040-1048.
Queiroz, R. P., Smit, D. P., Peters, R. P. H., & Vasconcelos-Santos, D. V. (2020). Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals. Ocular Immunology and Inflammation, 28(7), 1040-1048. https://doi.org/10.1080/09273948.2020.1772839
Queiroz RP, et al. Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals. Ocul Immunol Inflamm. 2020 Oct 2;28(7):1040-1048. PubMed PMID: 32657637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Double Trouble: Challenges in the Diagnosis and Management of Ocular Syphilis in HIV-infected Individuals. AU - Queiroz,Rafael de Pinho, AU - Smit,Derrick P, AU - Peters,Remco P H, AU - Vasconcelos-Santos,Daniel Vitor, Y1 - 2020/07/13/ PY - 2020/7/14/pubmed PY - 2020/7/14/medline PY - 2020/7/14/entrez KW - Challenges KW - HIV KW - diagnosis KW - management KW - ocular syphilis SP - 1040 EP - 1048 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 28 IS - 7 N2 - Syphilis and HIV infection may coexist in the same individual. Ocular syphilis and/or neurosyphilis may develop at any stage of coinfection, with a stronger association between ocular and neurosyphilis in individuals living with HIV, than in HIV-uninfected individuals. The diagnosis of ocular syphilis in HIV-infected and -uninfected patients remains with some controversy due to unspecific clinical manifestations and limited diagnostic tests. Penicillin is the mainstay of treatment of ocular syphilis, but alternative options are warranted. This review describes the epidemiology, pathophysiology, and clinical manifestations, as well as the diagnostic and therapeutic challenges posed by ocular syphilis against the background of HIV coinfection. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/32657637/Double_Trouble:_Challenges_in_the_Diagnosis_and_Management_of_Ocular_Syphilis_in_HIV-infected_Individuals. L2 - https://www.tandfonline.com/doi/full/10.1080/09273948.2020.1772839 DB - PRIME DP - Unbound Medicine ER -
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