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The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19.
Pharmacol Res Perspect. 2020 08; 8(4):e00623.PR

Abstract

Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS-CoV-2 and SARS-CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID-19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID-19 and potential therapeutic targets, focusing on the role of the renin-angiotensin-aldosterone system.

Authors+Show Affiliations

Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.Laboratory of Biochemistry and Cell Signalling, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.Anesthesia and Intensive Care, Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genoa, Italy.Laboratory of Biochemistry and Cell Signalling, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.Anesthesia and Intensive Care, Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genoa, Italy.Anesthesia and Intensive Care, Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genoa, Italy. Department of Surgical Sciences and Integrated Diagnostic (DISC), University of Genoa, Genoa, Italy.Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil. Rio de Janeiro Innovation Network in Nanosystems for Health-NanoSAÚDE/FAPERJ, Rio de Janeiro, Brazil. COVID-19 Virus Network, Ministry of Science and Technology, Innovation and Communication, Rio de Janeiro, Brazil.Laboratory of Biochemistry and Cell Signalling, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil. Rio de Janeiro Innovation Network in Nanosystems for Health-NanoSAÚDE/FAPERJ, Rio de Janeiro, Brazil. COVID-19 Virus Network, Ministry of Science and Technology, Innovation and Communication, Rio de Janeiro, Brazil.Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil. Rio de Janeiro Innovation Network in Nanosystems for Health-NanoSAÚDE/FAPERJ, Rio de Janeiro, Brazil. COVID-19 Virus Network, Ministry of Science and Technology, Innovation and Communication, Rio de Janeiro, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32658389

Citation

Braga, Cássia L., et al. "The Renin-angiotensin-aldosterone System: Role in Pathogenesis and Potential Therapeutic Target in COVID-19." Pharmacology Research & Perspectives, vol. 8, no. 4, 2020, pp. e00623.
Braga CL, Silva-Aguiar RP, Battaglini D, et al. The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19. Pharmacol Res Perspect. 2020;8(4):e00623.
Braga, C. L., Silva-Aguiar, R. P., Battaglini, D., Peruchetti, D. B., Robba, C., Pelosi, P., Rocco, P. R. M., Caruso-Neves, C., & Silva, P. L. (2020). The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19. Pharmacology Research & Perspectives, 8(4), e00623. https://doi.org/10.1002/prp2.623
Braga CL, et al. The Renin-angiotensin-aldosterone System: Role in Pathogenesis and Potential Therapeutic Target in COVID-19. Pharmacol Res Perspect. 2020;8(4):e00623. PubMed PMID: 32658389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19. AU - Braga,Cássia L, AU - Silva-Aguiar,Rodrigo P, AU - Battaglini,Denise, AU - Peruchetti,Diogo B, AU - Robba,Chiara, AU - Pelosi,Paolo, AU - Rocco,Patricia R M, AU - Caruso-Neves,Celso, AU - Silva,Pedro L, PY - 2020/05/08/received PY - 2020/06/10/revised PY - 2020/06/11/accepted PY - 2020/7/14/entrez PY - 2020/7/14/pubmed PY - 2020/7/23/medline KW - COVID-19 KW - SARS-CoV-2 KW - angiotensin-converting enzyme KW - inflammation KW - therapy SP - e00623 EP - e00623 JF - Pharmacology research & perspectives JO - Pharmacol Res Perspect VL - 8 IS - 4 N2 - Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS-CoV-2 and SARS-CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID-19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID-19 and potential therapeutic targets, focusing on the role of the renin-angiotensin-aldosterone system. SN - 2052-1707 UR - https://www.unboundmedicine.com/medline/citation/32658389/The_renin_angiotensin_aldosterone_system:_Role_in_pathogenesis_and_potential_therapeutic_target_in_COVID_19_ L2 - https://doi.org/10.1002/prp2.623 DB - PRIME DP - Unbound Medicine ER -