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Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay.
J Virol Methods. 2020 10; 284:113925.JV

Abstract

The clinical and epidemiologic management of the SARS-CoV-2 pandemic is critically dependent on molecular assays with short turn-around time. We validated the novel Xpert Xpress SARS-CoV-2 assay using a commercial nucleic acid testing (Roche Cobas 6800). We found an excellent concordance over a range of SARS-CoV-2 loads and across established human coronaviruses.

Authors+Show Affiliations

Clinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.Clinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.Clinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.Clinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland.Laboratory Medicine, University Hospital Basel, Basel, Switzerland.Clinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland; Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Transplantation & Clinical Virology, Department Biomedicine, University of Basel, Basel, Switzerland.Clinical Bacteriology and Mycology, Laboratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Applied Microbiology Research, Laboratory Medicine, Department Biomedicine, University of Basel, Basel, Switzerland. Electronic address: adrian.egli@usb.ch.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32659240

Citation

Goldenberger, Daniel, et al. "Brief Validation of the Novel GeneXpert Xpress SARS-CoV-2 PCR Assay." Journal of Virological Methods, vol. 284, 2020, p. 113925.
Goldenberger D, Leuzinger K, Sogaard KK, et al. Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay. J Virol Methods. 2020;284:113925.
Goldenberger, D., Leuzinger, K., Sogaard, K. K., Gosert, R., Roloff, T., Naegele, K., Cuénod, A., Mari, A., Seth-Smith, H., Rentsch, K., Hinić, V., Hirsch, H. H., & Egli, A. (2020). Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay. Journal of Virological Methods, 284, 113925. https://doi.org/10.1016/j.jviromet.2020.113925
Goldenberger D, et al. Brief Validation of the Novel GeneXpert Xpress SARS-CoV-2 PCR Assay. J Virol Methods. 2020;284:113925. PubMed PMID: 32659240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay. AU - Goldenberger,Daniel, AU - Leuzinger,Karoline, AU - Sogaard,Kirstine K, AU - Gosert,Rainer, AU - Roloff,Tim, AU - Naegele,Klaudia, AU - Cuénod,Aline, AU - Mari,Alfredo, AU - Seth-Smith,Helena, AU - Rentsch,Katharina, AU - Hinić,Vladimira, AU - Hirsch,Hans H, AU - Egli,Adrian, Y1 - 2020/07/10/ PY - 2020/04/27/received PY - 2020/06/08/revised PY - 2020/06/30/accepted PY - 2020/7/14/pubmed PY - 2020/9/10/medline PY - 2020/7/14/entrez KW - COBAS 6800 KW - COVID-19 KW - Diagnostics KW - GeneXpert KW - NAT KW - PCR KW - Respiratory infection KW - SARS-CoV-2 KW - Viruses SP - 113925 EP - 113925 JF - Journal of virological methods JO - J Virol Methods VL - 284 N2 - The clinical and epidemiologic management of the SARS-CoV-2 pandemic is critically dependent on molecular assays with short turn-around time. We validated the novel Xpert Xpress SARS-CoV-2 assay using a commercial nucleic acid testing (Roche Cobas 6800). We found an excellent concordance over a range of SARS-CoV-2 loads and across established human coronaviruses. SN - 1879-0984 UR - https://www.unboundmedicine.com/medline/citation/32659240/Brief_validation_of_the_novel_GeneXpert_Xpress_SARS_CoV_2_PCR_assay_ DB - PRIME DP - Unbound Medicine ER -