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Transcription factor 21 expression in injured podocytes of glomerular diseases.
Sci Rep. 2020 Jul 13; 10(1):11516.SR

Abstract

Transcription factor 21 (TCF21) is one of the essential transcription factors in kidney development. To elucidate its influence on glomerular disease, we have investigated TCF21 expression in human and rat kidney tissue, and its urinary concentration. Immunohistological analysis suggested the highest TCF21 expression in nephrotic syndrome along with the urinary protein level. Urinary TCF21 concentration in human showed a positive correlation with its podocyte expression level. In nephrotic rat models, TCF21 expression in podocytes increased along with the severity of nephrotic syndrome. Next, in vitro experiments using Tcf21-expressing murine podocyte cell line, we could observe some Tcf21-dependent effects, related with actin cytoskeleton dysregulation and apoptosis. Our study illustrated TCF21 expression changes in vivo and its in vitro-functional significance injured podocytes.

Authors+Show Affiliations

Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. j-usui@md.tsukuba.ac.jp. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10065, USA. j-usui@md.tsukuba.ac.jp.Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8576, Japan. Division of Stem Cell Therapy, Distinguished Professor Units, The Institute of Medical Science, The University Tokyo, Tokyo, 108-8639, Japan.Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.Université Pierre Et Marie Curie Paris 06, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S1155, SorbonneUniversité, Paris, France.Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32661376

Citation

Usui, Joichi, et al. "Transcription Factor 21 Expression in Injured Podocytes of Glomerular Diseases." Scientific Reports, vol. 10, no. 1, 2020, p. 11516.
Usui J, Yaguchi M, Yamazaki S, et al. Transcription factor 21 expression in injured podocytes of glomerular diseases. Sci Rep. 2020;10(1):11516.
Usui, J., Yaguchi, M., Yamazaki, S., Takahashi-Kobayashi, M., Kawamura, T., Kaneko, S., Seshan, S. V., Ronco, P., & Yamagata, K. (2020). Transcription factor 21 expression in injured podocytes of glomerular diseases. Scientific Reports, 10(1), 11516. https://doi.org/10.1038/s41598-020-68422-3
Usui J, et al. Transcription Factor 21 Expression in Injured Podocytes of Glomerular Diseases. Sci Rep. 2020 Jul 13;10(1):11516. PubMed PMID: 32661376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcription factor 21 expression in injured podocytes of glomerular diseases. AU - Usui,Joichi, AU - Yaguchi,Misa, AU - Yamazaki,Satoshi, AU - Takahashi-Kobayashi,Mayumi, AU - Kawamura,Tetsuya, AU - Kaneko,Shuzo, AU - Seshan,Surya V, AU - Ronco,Pierre, AU - Yamagata,Kunihiro, Y1 - 2020/07/13/ PY - 2020/01/14/received PY - 2020/06/24/accepted PY - 2020/7/15/entrez PY - 2020/7/15/pubmed PY - 2020/7/15/medline SP - 11516 EP - 11516 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - Transcription factor 21 (TCF21) is one of the essential transcription factors in kidney development. To elucidate its influence on glomerular disease, we have investigated TCF21 expression in human and rat kidney tissue, and its urinary concentration. Immunohistological analysis suggested the highest TCF21 expression in nephrotic syndrome along with the urinary protein level. Urinary TCF21 concentration in human showed a positive correlation with its podocyte expression level. In nephrotic rat models, TCF21 expression in podocytes increased along with the severity of nephrotic syndrome. Next, in vitro experiments using Tcf21-expressing murine podocyte cell line, we could observe some Tcf21-dependent effects, related with actin cytoskeleton dysregulation and apoptosis. Our study illustrated TCF21 expression changes in vivo and its in vitro-functional significance injured podocytes. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/32661376/Transcription_factor_21_expression_in_injured_podocytes_of_glomerular_diseases L2 - http://dx.doi.org/10.1038/s41598-020-68422-3 DB - PRIME DP - Unbound Medicine ER -
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