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Profilin: many facets of a small protein.
Biophys Rev. 2020 Jul 13 [Online ahead of print]BR

Abstract

Profilin is a ubiquitously expressed protein well known as a key regulator of actin polymerisation. The actin cytoskeleton is involved in almost all cellular processes including motility, endocytosis, metabolism, signal transduction and gene transcription. Hence, profilin's role in the cell goes beyond its direct and essential function in regulating actin dynamics. This review will focus on the interactions of Profilin 1 and its ligands at the plasma membrane, in the cytoplasm and the nucleus of the cells and the regulation of profilin activity within those cell compartments. We will discuss the interactions of profilin in cell signalling pathways and highlight the importance of the cell context in the multiple functions that this small essential protein has in conjunction with its role in cytoskeletal organisation and dynamics. We will review some of the mechanisms that control profilin expression and the implications of changed expression of profilin in the light of cancer biology and other pathologies.

Authors+Show Affiliations

Centre for Bioactive Discovery in Health and Ageing, School of Science and Technology, University of New England, Armidale, Australia.Centre for Bioactive Discovery in Health and Ageing, School of Science and Technology, University of New England, Armidale, Australia. pmoens@une.edu.au.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32661903

Citation

Davey, Rhonda J., and Pierre Dj Moens. "Profilin: Many Facets of a Small Protein." Biophysical Reviews, 2020.
Davey RJ, Moens PD. Profilin: many facets of a small protein. Biophys Rev. 2020.
Davey, R. J., & Moens, P. D. (2020). Profilin: many facets of a small protein. Biophysical Reviews. https://doi.org/10.1007/s12551-020-00723-3
Davey RJ, Moens PD. Profilin: Many Facets of a Small Protein. Biophys Rev. 2020 Jul 13; PubMed PMID: 32661903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Profilin: many facets of a small protein. AU - Davey,Rhonda J, AU - Moens,Pierre Dj, Y1 - 2020/07/13/ PY - 2020/05/28/received PY - 2020/07/02/accepted PY - 2020/7/15/entrez KW - Cell motility KW - Cell proliferation KW - Cell signalling KW - Cytoskeletal organisation JF - Biophysical reviews JO - Biophys Rev N2 - Profilin is a ubiquitously expressed protein well known as a key regulator of actin polymerisation. The actin cytoskeleton is involved in almost all cellular processes including motility, endocytosis, metabolism, signal transduction and gene transcription. Hence, profilin's role in the cell goes beyond its direct and essential function in regulating actin dynamics. This review will focus on the interactions of Profilin 1 and its ligands at the plasma membrane, in the cytoplasm and the nucleus of the cells and the regulation of profilin activity within those cell compartments. We will discuss the interactions of profilin in cell signalling pathways and highlight the importance of the cell context in the multiple functions that this small essential protein has in conjunction with its role in cytoskeletal organisation and dynamics. We will review some of the mechanisms that control profilin expression and the implications of changed expression of profilin in the light of cancer biology and other pathologies. SN - 1867-2450 UR - https://www.unboundmedicine.com/medline/citation/32661903/Profilin:_many_facets_of_a_small_protein L2 - https://dx.doi.org/10.1007/s12551-020-00723-3 DB - PRIME DP - Unbound Medicine ER -
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