Tags

Type your tag names separated by a space and hit enter

HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44.
J Rheumatol. 1988 Nov; 15(11):1658-61.JR

Abstract

In a consecutive case study 231 patients with Crohn's disease were investigated for ankylosing spondylitis (AS) and HLA-A, B, C, DR antigen association. Eighteen patients (7.8%) had definite AS according to the New York criteria; 13 (72%) were HLA-B27 positive. The phenotype B27,B44 was seen in 8 patients (44%) compared to only 3 (1%) of 300 controls (p less than 10(-7), and 1 (0.5%) of 213 patients with Crohn's disease without AS (p less than 10(-7). We conclude that patients with the phenotype B27,B44 are highly at risk (relative risk = 68.8) for the common manifestation of Crohn's disease and AS.

Authors+Show Affiliations

Purrmann J
Department of Gastroenterology, University of Düsseldorf, FRG.
Zeidler H
No affiliation info available
Bertrams J
No affiliation info available
Juli E
No affiliation info available
Cleveland S
No affiliation info available
Berges W
No affiliation info available
Gemsa R
No affiliation info available
Specker C
No affiliation info available
Reis HE
No affiliation info available

MeSH

AdultCrohn DiseaseDisease SusceptibilityFemaleHLA-B AntigensHLA-B27 AntigenHLA-B44 AntigenHLA-C AntigensHumansMaleMiddle AgedPhenotypeRisk FactorsSpondylitis, Ankylosing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3266250

Citation

Purrmann, J, et al. "HLA Antigens in Ankylosing Spondylitis Associated With Crohn's Disease. Increased Frequency of the HLA Phenotype B27,B44." The Journal of Rheumatology, vol. 15, no. 11, 1988, pp. 1658-61.
Purrmann J, Zeidler H, Bertrams J, et al. HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44. J Rheumatol. 1988;15(11):1658-61.
Purrmann, J., Zeidler, H., Bertrams, J., Juli, E., Cleveland, S., Berges, W., Gemsa, R., Specker, C., & Reis, H. E. (1988). HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44. The Journal of Rheumatology, 15(11), 1658-61.
Purrmann J, et al. HLA Antigens in Ankylosing Spondylitis Associated With Crohn's Disease. Increased Frequency of the HLA Phenotype B27,B44. J Rheumatol. 1988;15(11):1658-61. PubMed PMID: 3266250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44. AU - Purrmann,J, AU - Zeidler,H, AU - Bertrams,J, AU - Juli,E, AU - Cleveland,S, AU - Berges,W, AU - Gemsa,R, AU - Specker,C, AU - Reis,H E, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 1658 EP - 61 JF - The Journal of rheumatology JO - J Rheumatol VL - 15 IS - 11 N2 - In a consecutive case study 231 patients with Crohn's disease were investigated for ankylosing spondylitis (AS) and HLA-A, B, C, DR antigen association. Eighteen patients (7.8%) had definite AS according to the New York criteria; 13 (72%) were HLA-B27 positive. The phenotype B27,B44 was seen in 8 patients (44%) compared to only 3 (1%) of 300 controls (p less than 10(-7), and 1 (0.5%) of 213 patients with Crohn's disease without AS (p less than 10(-7). We conclude that patients with the phenotype B27,B44 are highly at risk (relative risk = 68.8) for the common manifestation of Crohn's disease and AS. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/3266250/HLA_antigens_in_ankylosing_spondylitis_associated_with_Crohn's_disease__Increased_frequency_of_the_HLA_phenotype_B27B44_ DB - PRIME DP - Unbound Medicine ER -