Tags

Type your tag names separated by a space and hit enter

Current Status of COVID-19 (Pre)Clinical Vaccine Development.
Angew Chem Int Ed Engl. 2020 Oct 19; 59(43):18885-18897.AC

Abstract

The current COVID-19 pandemic has a tremendous impact on daily life world-wide. Despite the ability to dampen the spread of SARS-CoV-2, the causative agent of the diseases, through restrictive interventions, it is believed that only effective vaccines will provide sufficient control over the disease and revert societal live back to normal. At present, a double-digit number of efforts are devoted to the development of a vaccine against COVID-19. Here, we provide an overview of these (pre)clinical efforts and provide background information on the technologies behind these vaccines. In addition, we discuss potential hurdles that need to be addressed prior to mass scale clinical translation of successful vaccine candidates.

Links

PMC Free PDF

Authors+Show Affiliations

Ye T
Department of Pharmaceutics, Ghent University, Belgium.
Zhong Z
Department of Pharmaceutics, Ghent University, Belgium.
García-Sastre A
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Schotsaert M
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
De Geest BG
Department of Pharmaceutics, Ghent University, Belgium.

MeSH

COVID-19COVID-19 VaccinesGenetic VectorsHumansSARS-CoV-2Vaccines, DNAVaccines, InactivatedVaccines, Virus-Like Particle

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32663348

Citation

Ye, Tingting, et al. "Current Status of COVID-19 (Pre)Clinical Vaccine Development." Angewandte Chemie (International Ed. in English), vol. 59, no. 43, 2020, pp. 18885-18897.
Ye T, Zhong Z, García-Sastre A, et al. Current Status of COVID-19 (Pre)Clinical Vaccine Development. Angew Chem Int Ed Engl. 2020;59(43):18885-18897.
Ye, T., Zhong, Z., García-Sastre, A., Schotsaert, M., & De Geest, B. G. (2020). Current Status of COVID-19 (Pre)Clinical Vaccine Development. Angewandte Chemie (International Ed. in English), 59(43), 18885-18897. https://doi.org/10.1002/anie.202008319
Ye T, et al. Current Status of COVID-19 (Pre)Clinical Vaccine Development. Angew Chem Int Ed Engl. 2020 Oct 19;59(43):18885-18897. PubMed PMID: 32663348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current Status of COVID-19 (Pre)Clinical Vaccine Development. AU - Ye,Tingting, AU - Zhong,Zifu, AU - García-Sastre,Adolfo, AU - Schotsaert,Michael, AU - De Geest,Bruno G, Y1 - 2020/09/02/ PY - 2020/6/11/received PY - 2020/7/15/pubmed PY - 2020/12/23/medline PY - 2020/7/15/entrez KW - COVID-19 KW - SARS-CoV-2 KW - pandemic KW - vaccine SP - 18885 EP - 18897 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 59 IS - 43 N2 - The current COVID-19 pandemic has a tremendous impact on daily life world-wide. Despite the ability to dampen the spread of SARS-CoV-2, the causative agent of the diseases, through restrictive interventions, it is believed that only effective vaccines will provide sufficient control over the disease and revert societal live back to normal. At present, a double-digit number of efforts are devoted to the development of a vaccine against COVID-19. Here, we provide an overview of these (pre)clinical efforts and provide background information on the technologies behind these vaccines. In addition, we discuss potential hurdles that need to be addressed prior to mass scale clinical translation of successful vaccine candidates. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/32663348/Current_Status_of_COVID_19__Pre_Clinical_Vaccine_Development_ DB - PRIME DP - Unbound Medicine ER -