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A case presentation for positive SARS-CoV-2 RNA recurrence in a patient with a history of type 2 diabetes that had recovered from severe COVID-19.
Diabetes Res Clin Pract. 2020 Aug; 166:108300.DR

Abstract

Coronavirus disease 2019 (COVID-19) is considered to be spread primarily by people who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss a patient with severe COVID-19 and a history of type 2 diabetes who had a recurrence of positive SARS-CoV-2 ribonucleic acid (RNA) after recovering. The patient was initially discharged after two consecutive negative SARS-CoV-2 RNA tests and partially absorbed bilateral lesions on chest computed tomography (CT). However, at his first follow-up, reverse transcription-polymerase chain reaction (RT-PCR) assay with an oropharyngeal swab sample was positive for SARS-CoV-2. Despite this, he displayed no obvious clinical symptoms and improved chest CT. The patient was prescribed anti-viral medication. Eight consecutive RT-PCR assays on oropharyngeal swab specimens were conducted after he was re-admitted to our hospital. The results tested positive on the 12th, 14th, 19th, 23rd and 26th of March and negative on the 28th of March, and 6th and 12th of April. After his second discharge, he has tested negative for 5 weeks. This case highlights the importance of active surveillance of SARS-CoV-2 RNA during the follow-up period so that an infectivity assessment can be made.

Authors+Show Affiliations

The First Affiliated Hospital of University of South China, Hengyang 421000, Hunan, China.The First Affiliated Hospital of University of South China, Hengyang 421000, Hunan, China.The First Affiliated Hospital of University of South China, Hengyang 421000, Hunan, China.The First Affiliated Hospital of University of South China, Hengyang 421000, Hunan, China.Public Health Affiliated Hospital of University of South China, Hengyang 421000, Hunan, China.Affiliated Nanhua Hospital of University of South China, Hengyang 421000, Hunan, China.The First Affiliated Hospital of University of South China, Hengyang 421000, Hunan, China. Electronic address: tangjiancrk@163.com.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32663490

Citation

Dou, Chengyun, et al. "A Case Presentation for Positive SARS-CoV-2 RNA Recurrence in a Patient With a History of Type 2 Diabetes That Had Recovered From Severe COVID-19." Diabetes Research and Clinical Practice, vol. 166, 2020, p. 108300.
Dou C, Xie X, Peng Z, et al. A case presentation for positive SARS-CoV-2 RNA recurrence in a patient with a history of type 2 diabetes that had recovered from severe COVID-19. Diabetes Res Clin Pract. 2020;166:108300.
Dou, C., Xie, X., Peng, Z., Tang, H., Jiang, Z., Zhong, Z., & Tang, J. (2020). A case presentation for positive SARS-CoV-2 RNA recurrence in a patient with a history of type 2 diabetes that had recovered from severe COVID-19. Diabetes Research and Clinical Practice, 166, 108300. https://doi.org/10.1016/j.diabres.2020.108300
Dou C, et al. A Case Presentation for Positive SARS-CoV-2 RNA Recurrence in a Patient With a History of Type 2 Diabetes That Had Recovered From Severe COVID-19. Diabetes Res Clin Pract. 2020;166:108300. PubMed PMID: 32663490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case presentation for positive SARS-CoV-2 RNA recurrence in a patient with a history of type 2 diabetes that had recovered from severe COVID-19. AU - Dou,Chengyun, AU - Xie,Xia, AU - Peng,Zhongtian, AU - Tang,Haibo, AU - Jiang,Zheng, AU - Zhong,Zhefeng, AU - Tang,Jian, Y1 - 2020/07/12/ PY - 2020/05/20/received PY - 2020/06/07/revised PY - 2020/06/29/accepted PY - 2020/7/15/pubmed PY - 2020/9/22/medline PY - 2020/7/15/entrez KW - Coronavirus disease 2019 KW - Recurrence KW - SARS-CoV-2 KW - Severe KW - Type 2 diabetes SP - 108300 EP - 108300 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 166 N2 - Coronavirus disease 2019 (COVID-19) is considered to be spread primarily by people who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss a patient with severe COVID-19 and a history of type 2 diabetes who had a recurrence of positive SARS-CoV-2 ribonucleic acid (RNA) after recovering. The patient was initially discharged after two consecutive negative SARS-CoV-2 RNA tests and partially absorbed bilateral lesions on chest computed tomography (CT). However, at his first follow-up, reverse transcription-polymerase chain reaction (RT-PCR) assay with an oropharyngeal swab sample was positive for SARS-CoV-2. Despite this, he displayed no obvious clinical symptoms and improved chest CT. The patient was prescribed anti-viral medication. Eight consecutive RT-PCR assays on oropharyngeal swab specimens were conducted after he was re-admitted to our hospital. The results tested positive on the 12th, 14th, 19th, 23rd and 26th of March and negative on the 28th of March, and 6th and 12th of April. After his second discharge, he has tested negative for 5 weeks. This case highlights the importance of active surveillance of SARS-CoV-2 RNA during the follow-up period so that an infectivity assessment can be made. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/32663490/A_case_presentation_for_positive_SARS_CoV_2_RNA_recurrence_in_a_patient_with_a_history_of_type_2_diabetes_that_had_recovered_from_severe_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(20)30552-0 DB - PRIME DP - Unbound Medicine ER -