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Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study.
Environ Health. 2020 07 14; 19(1):83.EH

Abstract

BACKGROUND

Parabens are a group of esters of para-hydroxybenzoic acid utilized as antimicrobial preservatives in many personal care products. Epidemiological studies regarding the adverse effects of parabens on fetuses are limited. The aim of this study was to determine the association between placental paraben exposure and birth outcomes. We assessed paraben concentrations in placental tissue, which potentially gives a better understanding of fetal exposure than the maternal urinary concentrations which are the current golden standard.

METHODS

Placental tissue was collected immediately after birth from 142 mother-child pairs from the ENVIRONAGE birth cohort. The placental concentrations of four parabens (methyl (MeP), ethyl (EtP), propyl (PrP), and butyl (BuP)) were determined by ultra-performance liquid chromatography coupled with tandem mass-spectrometry. Generalized linear regression models were used to determine the association between paraben exposure levels and birth outcomes.

RESULTS

The geometric means of placental MeP, EtP, PrP, and BuP were 1.84, 2.16, 1.68 and 0.05 ng/g tissue, respectively. The sum of parabens (∑ parabens, including MeP, EtP and PrP) was negatively associated with birth weight in newborn girls (- 166 g, 95% CI: - 322, - 8.6, p = 0.04) after adjustment for a priori selected covariates. The sum of parabens was negatively associated with head circumference (- 0.6 cm, 95% CI: - 1.1, - 0.2, p = 0.008) and borderline associated with birth length (- 0.6 cm, 95% CI:-1.3, 0.1, p = 0.08). In newborn girls the placental concentration of EtP was negatively associated with head circumference (- 0.6 cm, 95% CI:-1.1, - 0.1, p = 0.01) and borderline significantly associated with birth weight and birth length. Lastly, placental EtP and ∑parabens were negatively associated with placental weight in newborn girls but not in newborn boys (- 45.3 g, 95% CI:-86.2, - 4.4, p = 0.03).

CONCLUSION

The negative association between maternal paraben exposure and birth outcomes warrants further research and follow-up over time to determine long term effects of gestational exposure to parabens.

Authors+Show Affiliations

Center for Environmental Sciences, Hasselt University, Agoralaan, 3590, Diepenbeek, Belgium. Karen.vrijens@uhasselt.be.Sciensano, Chemical and physical Health Risks, J. Wytsmanstraat 14, 1050, Brussels, Belgium.Sciensano, Chemical and physical Health Risks, J. Wytsmanstraat 14, 1050, Brussels, Belgium.Center for Environmental Sciences, Hasselt University, Agoralaan, 3590, Diepenbeek, Belgium.Center for Environmental Sciences, Hasselt University, Agoralaan, 3590, Diepenbeek, Belgium.Sciensano, Chemical and physical Health Risks, J. Wytsmanstraat 14, 1050, Brussels, Belgium.Sciensano, Chemical and physical Health Risks, J. Wytsmanstraat 14, 1050, Brussels, Belgium.Center for Environmental Sciences, Hasselt University, Agoralaan, 3590, Diepenbeek, Belgium. Department of Public Health, Environment & Health Unit, Leuven University (KU Leuven), Kapucijnenvoer 35, 3000, Leuven, Belgium.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32664952

Citation

Vrijens, Karen, et al. "Weight and Head Circumference at Birth in Function of Placental Paraben Load in Belgium: an ENVIRONAGE Birth Cohort Study." Environmental Health : a Global Access Science Source, vol. 19, no. 1, 2020, p. 83.
Vrijens K, Van Overmeire I, De Cremer K, et al. Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study. Environ Health. 2020;19(1):83.
Vrijens, K., Van Overmeire, I., De Cremer, K., Neven, K. Y., Carollo, R. M., Vleminckx, C., Van Loco, J., & Nawrot, T. S. (2020). Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study. Environmental Health : a Global Access Science Source, 19(1), 83. https://doi.org/10.1186/s12940-020-00635-5
Vrijens K, et al. Weight and Head Circumference at Birth in Function of Placental Paraben Load in Belgium: an ENVIRONAGE Birth Cohort Study. Environ Health. 2020 07 14;19(1):83. PubMed PMID: 32664952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study. AU - Vrijens,Karen, AU - Van Overmeire,Ilse, AU - De Cremer,Koen, AU - Neven,Kristof Y, AU - Carollo,Riccardo M, AU - Vleminckx,Christiane, AU - Van Loco,Joris, AU - Nawrot,Tim S, Y1 - 2020/07/14/ PY - 2020/02/13/received PY - 2020/07/03/accepted PY - 2020/7/16/entrez PY - 2020/7/16/pubmed PY - 2020/7/16/medline KW - Birth cohort KW - Birth weight and length KW - Paraben exposure KW - Placental paraben concentrations SP - 83 EP - 83 JF - Environmental health : a global access science source JO - Environ Health VL - 19 IS - 1 N2 - BACKGROUND: Parabens are a group of esters of para-hydroxybenzoic acid utilized as antimicrobial preservatives in many personal care products. Epidemiological studies regarding the adverse effects of parabens on fetuses are limited. The aim of this study was to determine the association between placental paraben exposure and birth outcomes. We assessed paraben concentrations in placental tissue, which potentially gives a better understanding of fetal exposure than the maternal urinary concentrations which are the current golden standard. METHODS: Placental tissue was collected immediately after birth from 142 mother-child pairs from the ENVIRONAGE birth cohort. The placental concentrations of four parabens (methyl (MeP), ethyl (EtP), propyl (PrP), and butyl (BuP)) were determined by ultra-performance liquid chromatography coupled with tandem mass-spectrometry. Generalized linear regression models were used to determine the association between paraben exposure levels and birth outcomes. RESULTS: The geometric means of placental MeP, EtP, PrP, and BuP were 1.84, 2.16, 1.68 and 0.05 ng/g tissue, respectively. The sum of parabens (∑ parabens, including MeP, EtP and PrP) was negatively associated with birth weight in newborn girls (- 166 g, 95% CI: - 322, - 8.6, p = 0.04) after adjustment for a priori selected covariates. The sum of parabens was negatively associated with head circumference (- 0.6 cm, 95% CI: - 1.1, - 0.2, p = 0.008) and borderline associated with birth length (- 0.6 cm, 95% CI:-1.3, 0.1, p = 0.08). In newborn girls the placental concentration of EtP was negatively associated with head circumference (- 0.6 cm, 95% CI:-1.1, - 0.1, p = 0.01) and borderline significantly associated with birth weight and birth length. Lastly, placental EtP and ∑parabens were negatively associated with placental weight in newborn girls but not in newborn boys (- 45.3 g, 95% CI:-86.2, - 4.4, p = 0.03). CONCLUSION: The negative association between maternal paraben exposure and birth outcomes warrants further research and follow-up over time to determine long term effects of gestational exposure to parabens. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/32664952/Weight_and_head_circumference_at_birth_in_function_of_placental_paraben_load_in_Belgium:_an_ENVIRONAGE_birth_cohort_study_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-020-00635-5 DB - PRIME DP - Unbound Medicine ER -