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Oral challenge test with sodium metabisulfite in steroid-dependent asthmatic patients.
Allergol Immunopathol (Madr) 1988 Nov-Dec; 16(6):393-6AI

Abstract

Oral challenge tests were carried out with sodium metabisulfite solution doses of 0.5, 1, 10, 25, 50 mg and encapsulated doses of 100 and 200 mg, as well as with lactose-placebo, on 44 non-atopic patients with steroid-dependent bronchial asthma, without clinical evidence of intolerance to these agents. Only those patients with an acceptable and not very labile pulmonary function were tested. A single-blind challenge protocol was performed in 22 patients (sodium metabisulfite solutions at pH 2.2 to 2.6) and the positive responses were confirmed by double-blind challenge. The other 22 were tested directly in a double-blind manner (pH4). Initially, 6/44 presented a positive reaction. However, a careful analysis and the confirmation by double-blind challenge of the positive responses obtained with the single-blind test, allowed us to identify 4 false positive responses. Thus, the true prevalence of sulfite sensitivity in our population is 4.5%. A patient with intolerance to sulfite agents also suffered aspirin-induced asthma. The labile tendency of the pulmonary function of the asthmatic patients may have contributed to some false positive reactions and probably explain the very high prevalence found in some studies. It does not appear that the variations of pH decisively influence the result of the challenge test.

Authors+Show Affiliations

Sección de Alergia y Servicio de Farmacia, Hospital Doctor Peset, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

3266541

Citation

Prieto, L, et al. "Oral Challenge Test With Sodium Metabisulfite in Steroid-dependent Asthmatic Patients." Allergologia Et Immunopathologia, vol. 16, no. 6, 1988, pp. 393-6.
Prieto L, Juyol M, Paricio A, et al. Oral challenge test with sodium metabisulfite in steroid-dependent asthmatic patients. Allergol Immunopathol (Madr). 1988;16(6):393-6.
Prieto, L., Juyol, M., Paricio, A., Martínez, M. A., Palop, J., & Castro, J. (1988). Oral challenge test with sodium metabisulfite in steroid-dependent asthmatic patients. Allergologia Et Immunopathologia, 16(6), pp. 393-6.
Prieto L, et al. Oral Challenge Test With Sodium Metabisulfite in Steroid-dependent Asthmatic Patients. Allergol Immunopathol (Madr). 1988;16(6):393-6. PubMed PMID: 3266541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral challenge test with sodium metabisulfite in steroid-dependent asthmatic patients. AU - Prieto,L, AU - Juyol,M, AU - Paricio,A, AU - Martínez,M A, AU - Palop,J, AU - Castro,J, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 393 EP - 6 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 16 IS - 6 N2 - Oral challenge tests were carried out with sodium metabisulfite solution doses of 0.5, 1, 10, 25, 50 mg and encapsulated doses of 100 and 200 mg, as well as with lactose-placebo, on 44 non-atopic patients with steroid-dependent bronchial asthma, without clinical evidence of intolerance to these agents. Only those patients with an acceptable and not very labile pulmonary function were tested. A single-blind challenge protocol was performed in 22 patients (sodium metabisulfite solutions at pH 2.2 to 2.6) and the positive responses were confirmed by double-blind challenge. The other 22 were tested directly in a double-blind manner (pH4). Initially, 6/44 presented a positive reaction. However, a careful analysis and the confirmation by double-blind challenge of the positive responses obtained with the single-blind test, allowed us to identify 4 false positive responses. Thus, the true prevalence of sulfite sensitivity in our population is 4.5%. A patient with intolerance to sulfite agents also suffered aspirin-induced asthma. The labile tendency of the pulmonary function of the asthmatic patients may have contributed to some false positive reactions and probably explain the very high prevalence found in some studies. It does not appear that the variations of pH decisively influence the result of the challenge test. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/3266541/Oral_challenge_test_with_sodium_metabisulfite_in_steroid_dependent_asthmatic_patients_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -