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Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia.
Eur J Case Rep Intern Med. 2020; 7(7):001822.EJ

Abstract

Background

In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19).

Case description

We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids.

Discussion

Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome.

LEARNING POINTS

One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation.Corticosteroid therapy may be useful in these patients.

Authors+Show Affiliations

Department of Infectious Diseases, Strasbourg University Hospital, Strasbourg, France.Department of Infectious Diseases, Strasbourg University Hospital, Strasbourg, France.Department of Clinical Immunology and Internal Medicine, Strasbourg University Hospital, Strasbourg, France.Department of Infectious Diseases, Strasbourg University Hospital, Strasbourg, France.Department of Infectious Diseases, Strasbourg University Hospital, Strasbourg, France.Department of Infectious Diseases, Strasbourg University Hospital, Strasbourg, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32665942

Citation

Ruch, Yvon, et al. "Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia." European Journal of Case Reports in Internal Medicine, vol. 7, no. 7, 2020, p. 001822.
Ruch Y, Kaeuffer C, Guffroy A, et al. Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia. Eur J Case Rep Intern Med. 2020;7(7):001822.
Ruch, Y., Kaeuffer, C., Guffroy, A., Lefebvre, N., Hansmann, Y., & Danion, F. (2020). Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia. European Journal of Case Reports in Internal Medicine, 7(7), 001822. https://doi.org/10.12890/2020_001822
Ruch Y, et al. Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia. Eur J Case Rep Intern Med. 2020;7(7):001822. PubMed PMID: 32665942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia. AU - Ruch,Yvon, AU - Kaeuffer,Charlotte, AU - Guffroy,Aurélien, AU - Lefebvre,Nicolas, AU - Hansmann,Yves, AU - Danion,François, Y1 - 2020/07/02/ PY - 2020/06/18/received PY - 2020/06/20/accepted PY - 2020/7/16/entrez PY - 2020/7/16/pubmed PY - 2020/7/16/medline KW - COVID-19 KW - computed tomography KW - coronavirus KW - corticosteroids KW - cytokine storm syndrome SP - 001822 EP - 001822 JF - European journal of case reports in internal medicine JO - Eur J Case Rep Intern Med VL - 7 IS - 7 N2 - Background: In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19). Case description: We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids. Discussion: Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome. LEARNING POINTS: One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation.Corticosteroid therapy may be useful in these patients. SN - 2284-2594 UR - https://www.unboundmedicine.com/medline/citation/32665942/Rapid_Radiological_Worsening_and_Cytokine_Storm_Syndrome_in_COVID_19_Pneumonia_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32665942/ DB - PRIME DP - Unbound Medicine ER -
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