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Regulation of Autophagy in Neurodegenerative Diseases by Natural Products.
Adv Exp Med Biol. 2020; 1207:725-730.AE

Abstract

Neurodegenerative diseases mainly include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD). It is now found that these diseases may be related to autophagic dysfunction. The mechanism is due to abnormalities in autophagy, which lead to abnormal or misfolded proteins accumulating in the cytoplasm, nucleus, and extracellular inclusion bodies, causing neuronal organelle damage and synaptic dysfunction. Since these diseases are much complex, the effect of monotherapy is not significantly affected. There is still a need to strengthen the study of anti-neurodegenerative drugs. Natural products should be a good source for the new drug discovery since most of natural products are multiple-target compounds. In this chapter, we reviewed some progress on studying resveratrol, curcumin, tripterine, and paeoniflorin. These natural products can eliminate abnormal protein aggregates by regulating autophagy, and thereby these compounds are promising to be used in prevention and treatment of neurodegenerative diseases in the future.

Authors+Show Affiliations

Department of Pharmacology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China.Department of Pharmacology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China. xjli@bjmu.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32671789

Citation

Liu, Shuaishuai, and Xuejun Li. "Regulation of Autophagy in Neurodegenerative Diseases By Natural Products." Advances in Experimental Medicine and Biology, vol. 1207, 2020, pp. 725-730.
Liu S, Li X. Regulation of Autophagy in Neurodegenerative Diseases by Natural Products. Adv Exp Med Biol. 2020;1207:725-730.
Liu, S., & Li, X. (2020). Regulation of Autophagy in Neurodegenerative Diseases by Natural Products. Advances in Experimental Medicine and Biology, 1207, 725-730. https://doi.org/10.1007/978-981-15-4272-5_54
Liu S, Li X. Regulation of Autophagy in Neurodegenerative Diseases By Natural Products. Adv Exp Med Biol. 2020;1207:725-730. PubMed PMID: 32671789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of Autophagy in Neurodegenerative Diseases by Natural Products. AU - Liu,Shuaishuai, AU - Li,Xuejun, PY - 2020/7/17/entrez PY - 2020/7/17/pubmed PY - 2020/9/8/medline KW - Autophagy KW - Multi-target KW - Natural product KW - Neurodegenerative diseases SP - 725 EP - 730 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 1207 N2 - Neurodegenerative diseases mainly include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD). It is now found that these diseases may be related to autophagic dysfunction. The mechanism is due to abnormalities in autophagy, which lead to abnormal or misfolded proteins accumulating in the cytoplasm, nucleus, and extracellular inclusion bodies, causing neuronal organelle damage and synaptic dysfunction. Since these diseases are much complex, the effect of monotherapy is not significantly affected. There is still a need to strengthen the study of anti-neurodegenerative drugs. Natural products should be a good source for the new drug discovery since most of natural products are multiple-target compounds. In this chapter, we reviewed some progress on studying resveratrol, curcumin, tripterine, and paeoniflorin. These natural products can eliminate abnormal protein aggregates by regulating autophagy, and thereby these compounds are promising to be used in prevention and treatment of neurodegenerative diseases in the future. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/32671789/Regulation_of_Autophagy_in_Neurodegenerative_Diseases_by_Natural_Products_ DB - PRIME DP - Unbound Medicine ER -