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Targeting zinc metalloenzymes in coronavirus disease 2019.
Br J Pharmacol. 2020 11; 177(21):4887-4898.BJ

Abstract

Several lines of evidence support a link between the essential element zinc and the coronavirus disease 2019 (COVID-19). An important fact is that zinc is present in proteins of humans and of viruses. Some zinc sites in viral enzymes may serve as drug targets and may liberate zinc ions, thus leading to changes in intracellular concentration of zinc ions, while increased intracellular zinc may induce biological effects in both the host and the virus. Drugs such as chloroquine may contribute to increased intracellular zinc. Moreover, clinical trials on the use of zinc alone or in addition to other drugs in the prophylaxis/treatment of COVID-19 are ongoing. Thereby, we aim to discuss the rationale for targeting zinc metalloenzymes as a new strategy for the treatment of COVID-19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc.

Authors+Show Affiliations

Department of Pharmacobiology, Jagiellonian University Medical College, Kraków, Poland.Department of Animal Physiology and Pharmacology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland.Department of Pharmacobiology, Jagiellonian University Medical College, Kraków, Poland. Laboratory of Trace Elements Neurobiology, Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.Department of Pharmacobiology, Jagiellonian University Medical College, Kraków, Poland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32671829

Citation

Doboszewska, Urszula, et al. "Targeting Zinc Metalloenzymes in Coronavirus Disease 2019." British Journal of Pharmacology, vol. 177, no. 21, 2020, pp. 4887-4898.
Doboszewska U, Wlaź P, Nowak G, et al. Targeting zinc metalloenzymes in coronavirus disease 2019. Br J Pharmacol. 2020;177(21):4887-4898.
Doboszewska, U., Wlaź, P., Nowak, G., & Młyniec, K. (2020). Targeting zinc metalloenzymes in coronavirus disease 2019. British Journal of Pharmacology, 177(21), 4887-4898. https://doi.org/10.1111/bph.15199
Doboszewska U, et al. Targeting Zinc Metalloenzymes in Coronavirus Disease 2019. Br J Pharmacol. 2020;177(21):4887-4898. PubMed PMID: 32671829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeting zinc metalloenzymes in coronavirus disease 2019. AU - Doboszewska,Urszula, AU - Wlaź,Piotr, AU - Nowak,Gabriel, AU - Młyniec,Katarzyna, Y1 - 2020/08/17/ PY - 2020/05/29/received PY - 2020/06/22/revised PY - 2020/07/05/accepted PY - 2020/7/17/pubmed PY - 2020/10/28/medline PY - 2020/7/17/entrez KW - COVID-19 KW - SARS-CoV-2 KW - metalloenzyme KW - zinc KW - zinc ejecting drug KW - zinc finger SP - 4887 EP - 4898 JF - British journal of pharmacology JO - Br J Pharmacol VL - 177 IS - 21 N2 - Several lines of evidence support a link between the essential element zinc and the coronavirus disease 2019 (COVID-19). An important fact is that zinc is present in proteins of humans and of viruses. Some zinc sites in viral enzymes may serve as drug targets and may liberate zinc ions, thus leading to changes in intracellular concentration of zinc ions, while increased intracellular zinc may induce biological effects in both the host and the virus. Drugs such as chloroquine may contribute to increased intracellular zinc. Moreover, clinical trials on the use of zinc alone or in addition to other drugs in the prophylaxis/treatment of COVID-19 are ongoing. Thereby, we aim to discuss the rationale for targeting zinc metalloenzymes as a new strategy for the treatment of COVID-19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. SN - 1476-5381 UR - https://www.unboundmedicine.com/medline/citation/32671829/Targeting_zinc_metalloenzymes_in_coronavirus_disease_2019_ DB - PRIME DP - Unbound Medicine ER -