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Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study.
BMC Infect Dis. 2020 Jul 16; 20(1):519.BI

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early.

METHODS

In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve.

RESULTS

Significantly, disease severity was associated with age (r = 0.458, P < 0.001), comorbidities (r = 0.445, P < 0.001), white cell count (r = 0.229, P = 0.006), neutrophil count (r = 0.238, P = 0.004), lymphocyte count (r = - 0.295, P < 0.001), albumin (r = - 0.603, P < 0.001), high-density lipoprotein cholesterol (r = - 0.362, P < 0.001), serum potassium (r = - 0.237, P = 0.004), plasma glucose (r = 0.383, P < 0.001), total bilirubin (r = 0.340, P < 0.001), serum amyloid A (r = 0.58, P < 0.001), procalcitonin (r = 0.345, P < 0.001), C-reactive protein (r = 0.477, P < 0.001), lactate dehydrogenase (r = 0.548, P < 0.001), aspartate aminotransferase (r = 0.342, P < 0.001), alanine aminotransferase (r = 0.264, P = 0.001), erythrocyte sedimentation rate (r = 0.284, P = 0.001) and D-dimer (r = 0.477, P < 0.001) .

CONCLUSIONS

With the following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 μg/mL, serum amyloid A > 100.02 mg/L, or albumin < 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium, high-density lipoprotein cholesterol and procalcitonin may also be a prognostic indicator.

Authors+Show Affiliations

Department of Neurology, Hubei NO.3 People's Hospital of Jianghan University, 26 Zhongshan Road, Qiaokou District, Wuhan, China.Department of Neurology, Hubei NO.3 People's Hospital of Jianghan University, 26 Zhongshan Road, Qiaokou District, Wuhan, China.Department of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.Department of Neurology, Hubei NO.3 People's Hospital of Jianghan University, 26 Zhongshan Road, Qiaokou District, Wuhan, China.Department of Neurology, Hubei NO.3 People's Hospital of Jianghan University, 26 Zhongshan Road, Qiaokou District, Wuhan, China.Department of Neurology, Hubei NO.3 People's Hospital of Jianghan University, 26 Zhongshan Road, Qiaokou District, Wuhan, China.Department of Neurology, Hubei NO.3 People's Hospital of Jianghan University, 26 Zhongshan Road, Qiaokou District, Wuhan, China. hqzsyy@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32677918

Citation

Wang, Dan, et al. "Correlation Analysis Between Disease Severity and Clinical and Biochemical Characteristics of 143 Cases of COVID-19 in Wuhan, China: a Descriptive Study." BMC Infectious Diseases, vol. 20, no. 1, 2020, p. 519.
Wang D, Li R, Wang J, et al. Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study. BMC Infect Dis. 2020;20(1):519.
Wang, D., Li, R., Wang, J., Jiang, Q., Gao, C., Yang, J., Ge, L., & Hu, Q. (2020). Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study. BMC Infectious Diseases, 20(1), 519. https://doi.org/10.1186/s12879-020-05242-w
Wang D, et al. Correlation Analysis Between Disease Severity and Clinical and Biochemical Characteristics of 143 Cases of COVID-19 in Wuhan, China: a Descriptive Study. BMC Infect Dis. 2020 Jul 16;20(1):519. PubMed PMID: 32677918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study. AU - Wang,Dan, AU - Li,Ruifang, AU - Wang,Juan, AU - Jiang,Qunqun, AU - Gao,Chang, AU - Yang,Juan, AU - Ge,Lintong, AU - Hu,Qing, Y1 - 2020/07/16/ PY - 2020/03/25/received PY - 2020/07/07/accepted PY - 2020/7/18/entrez PY - 2020/7/18/pubmed PY - 2020/7/28/medline KW - COVID-19 KW - Correlation analysis KW - Prognostic indicator KW - SARS-CoV-2 SP - 519 EP - 519 JF - BMC infectious diseases JO - BMC Infect Dis VL - 20 IS - 1 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early. METHODS: In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve. RESULTS: Significantly, disease severity was associated with age (r = 0.458, P < 0.001), comorbidities (r = 0.445, P < 0.001), white cell count (r = 0.229, P = 0.006), neutrophil count (r = 0.238, P = 0.004), lymphocyte count (r = - 0.295, P < 0.001), albumin (r = - 0.603, P < 0.001), high-density lipoprotein cholesterol (r = - 0.362, P < 0.001), serum potassium (r = - 0.237, P = 0.004), plasma glucose (r = 0.383, P < 0.001), total bilirubin (r = 0.340, P < 0.001), serum amyloid A (r = 0.58, P < 0.001), procalcitonin (r = 0.345, P < 0.001), C-reactive protein (r = 0.477, P < 0.001), lactate dehydrogenase (r = 0.548, P < 0.001), aspartate aminotransferase (r = 0.342, P < 0.001), alanine aminotransferase (r = 0.264, P = 0.001), erythrocyte sedimentation rate (r = 0.284, P = 0.001) and D-dimer (r = 0.477, P < 0.001) . CONCLUSIONS: With the following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 μg/mL, serum amyloid A > 100.02 mg/L, or albumin < 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium, high-density lipoprotein cholesterol and procalcitonin may also be a prognostic indicator. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/32677918/Correlation_analysis_between_disease_severity_and_clinical_and_biochemical_characteristics_of_143_cases_of_COVID_19_in_Wuhan_China:_a_descriptive_study_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05242-w DB - PRIME DP - Unbound Medicine ER -