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Extracorporeal membrane oxygenation and COVID-19: The causes of failure.
J Card Surg. 2020 Oct; 35(10):2838-2843.JC

Abstract

INTRODUCTION

Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a therapeutic strategy for the coronavirus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). There are inconclusive data in this regard and causes of VV-ECMO failure are not yet understood well.

CASE SERIES

Here, seven patients with COVID-19-induced ARDS who underwent VV-ECMO introduced and causes of VV-ECMO failure discussed. Medical records of seven COVID-19 patients treated with VV-ECMO were retrospectively evaluated to determine the clinical outcomes of VV-ECMO. Oxygenator failure occurred in four patients whom needed to oxygenator replacement. Successful VV-ECMO decannulation was done in three patients, however finally one patient survived.

CONCLUSIONS

Hypercoagulability state and oxygenator failure were the most main etiologies for VV-ECMO failure in our study. All patients with COVID-19 undergoing VV-ECMO should be monitored for such problems and highly specialized healthcare team should monitor the patients during VV-ECMO.

Authors+Show Affiliations

Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Student Research Committee, Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32678961

Citation

Ahmadi, Zargham Hossein, et al. "Extracorporeal Membrane Oxygenation and COVID-19: the Causes of Failure." Journal of Cardiac Surgery, vol. 35, no. 10, 2020, pp. 2838-2843.
Ahmadi ZH, Jahangirifard A, Farzanegan B, et al. Extracorporeal membrane oxygenation and COVID-19: The causes of failure. J Card Surg. 2020;35(10):2838-2843.
Ahmadi, Z. H., Jahangirifard, A., Farzanegan, B., Tabarsi, P., Abtahian, Z., Abedini, A., Sharifi, M., Jadbabaei, A. N., Mafhumi, Y., Moslem, A., Sistani, M., Yousefian, S., Saffaei, A., & Dastan, F. (2020). Extracorporeal membrane oxygenation and COVID-19: The causes of failure. Journal of Cardiac Surgery, 35(10), 2838-2843. https://doi.org/10.1111/jocs.14867
Ahmadi ZH, et al. Extracorporeal Membrane Oxygenation and COVID-19: the Causes of Failure. J Card Surg. 2020;35(10):2838-2843. PubMed PMID: 32678961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extracorporeal membrane oxygenation and COVID-19: The causes of failure. AU - Ahmadi,Zargham Hossein, AU - Jahangirifard,Alireza, AU - Farzanegan,Behrooz, AU - Tabarsi,Payam, AU - Abtahian,Zahra, AU - Abedini,Atefeh, AU - Sharifi,Mehrzad, AU - Jadbabaei,Amir Naser, AU - Mafhumi,Yadollah, AU - Moslem,Ali, AU - Sistani,Marjan, AU - Yousefian,Sahar, AU - Saffaei,Ali, AU - Dastan,Farzaneh, Y1 - 2020/07/17/ PY - 2020/05/23/received PY - 2020/06/19/revised PY - 2020/07/06/accepted PY - 2020/7/18/pubmed PY - 2020/10/23/medline PY - 2020/7/18/entrez KW - SARS coronavirus KW - SARS-CoV infection KW - acute respiratory distress syndrome KW - extracorporeal membrane oxygenation KW - hypercoagulability SP - 2838 EP - 2843 JF - Journal of cardiac surgery JO - J Card Surg VL - 35 IS - 10 N2 - INTRODUCTION: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a therapeutic strategy for the coronavirus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). There are inconclusive data in this regard and causes of VV-ECMO failure are not yet understood well. CASE SERIES: Here, seven patients with COVID-19-induced ARDS who underwent VV-ECMO introduced and causes of VV-ECMO failure discussed. Medical records of seven COVID-19 patients treated with VV-ECMO were retrospectively evaluated to determine the clinical outcomes of VV-ECMO. Oxygenator failure occurred in four patients whom needed to oxygenator replacement. Successful VV-ECMO decannulation was done in three patients, however finally one patient survived. CONCLUSIONS: Hypercoagulability state and oxygenator failure were the most main etiologies for VV-ECMO failure in our study. All patients with COVID-19 undergoing VV-ECMO should be monitored for such problems and highly specialized healthcare team should monitor the patients during VV-ECMO. SN - 1540-8191 UR - https://www.unboundmedicine.com/medline/citation/32678961/Extracorporeal_membrane_oxygenation_and_COVID_19:_The_causes_of_failure_ DB - PRIME DP - Unbound Medicine ER -