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Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know?
Eur J Pharmacol. 2020 Sep 15; 883:173373.EJ

Abstract

The first cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) infections were recorded in China in November 2019. Since its appearance in China at the end of last year, the virus has spread to all continents causing a "global pandemic". To date, some aspects remain to be investigate about the pathophysiology of this viral infection. One of the aspects to be still clarified is the correlation between the renin-angiotensin system (RAS) and SARS-CoV-2 infection. RAS is a physiological system playing a key role in different human body functions regulation. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE-2), a component of RAS, as a potential factor of cell penetration and infectivity; in addition, in the different infection stages, a functional variation of the RAS has been noted. In this article, we discuss the correlation between the role of RAS and system-modifying agents, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs) and direct renin inhibitors (DRIs), with SARS-CoV-2 infection.

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Authors+Show Affiliations

Vitiello A
Usl Umbria 1, Perugia, Italy.
Ferrara F
Usl Umbria 1, Perugia, Italy. Electronic address: francesco.ferrara@uslumbria1.it.

MeSH

Angiotensin Receptor AntagonistsAngiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsBetacoronavirusCOVID-19Cardiovascular DiseasesCoronavirus InfectionsHumansPandemicsPeptidyl-Dipeptidase APneumonia, ViralRenin-Angiotensin SystemSARS-CoV-2

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32679185

Citation

Vitiello, Antonio, and Francesco Ferrara. "Correlation Between Renin-angiotensin System and Severe Acute Respiratory Syndrome Coronavirus 2 Infection: what Do We Know?" European Journal of Pharmacology, vol. 883, 2020, p. 173373.
Vitiello A, Ferrara F. Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know? Eur J Pharmacol. 2020;883:173373.
Vitiello, A., & Ferrara, F. (2020). Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know? European Journal of Pharmacology, 883, 173373. https://doi.org/10.1016/j.ejphar.2020.173373
Vitiello A, Ferrara F. Correlation Between Renin-angiotensin System and Severe Acute Respiratory Syndrome Coronavirus 2 Infection: what Do We Know. Eur J Pharmacol. 2020 Sep 15;883:173373. PubMed PMID: 32679185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know? AU - Vitiello,Antonio, AU - Ferrara,Francesco, Y1 - 2020/07/15/ PY - 2020/5/12/received PY - 2020/7/10/revised PY - 2020/7/13/accepted PY - 2020/7/18/pubmed PY - 2020/9/17/medline PY - 2020/7/18/entrez KW - ACE-2 KW - Coronavirus KW - Infection KW - Pharmacology KW - RAS KW - Renin KW - SARS-CoV-2 SP - 173373 EP - 173373 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 883 N2 - The first cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) infections were recorded in China in November 2019. Since its appearance in China at the end of last year, the virus has spread to all continents causing a "global pandemic". To date, some aspects remain to be investigate about the pathophysiology of this viral infection. One of the aspects to be still clarified is the correlation between the renin-angiotensin system (RAS) and SARS-CoV-2 infection. RAS is a physiological system playing a key role in different human body functions regulation. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE-2), a component of RAS, as a potential factor of cell penetration and infectivity; in addition, in the different infection stages, a functional variation of the RAS has been noted. In this article, we discuss the correlation between the role of RAS and system-modifying agents, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs) and direct renin inhibitors (DRIs), with SARS-CoV-2 infection. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/32679185/Correlation_between_renin_angiotensin_system_and_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_infection:_What_do_we_know DB - PRIME DP - Unbound Medicine ER -