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High altitude reduces infection rate of COVID-19 but not case-fatality rate.
Respir Physiol Neurobiol. 2020 10; 281:103494.RP

Abstract

Coronavirus disease 19 (COVID-19) is a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is suggested that life at high altitude may reduce COVID-19 infections and case-fatality rates (cases/deaths). We study data from Peru COVID-19 pandemics, which first case was recorded on March 6th, 2020. By June 13, 2020 there were 6498 deaths, and 224,132 SARS-CoV-2 positives. Using data from 185 capitals of provinces with altitudes ranging from 3 to 4342 m, we confirm previous reports that infection with COVID-19 at high altitude is reduced. However, case-fatality rate is not dependent of altitude. We have also presented first evidence that female protection towards death by COVID-19 is reduced as altitude of residence increases.

Authors+Show Affiliations

Department of Computer Science, Universidad Nacional de Ingeniería, Lima, Peru. Electronic address: jsegoviaj@uni.edu.pe.University Informatics & Systems Office, Universidad de Lima, Lima, Peru.High Altitude Research Institute, Laboratories of Investigation and Development (LID), Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

32679369

Citation

Segovia-Juarez, Jose, et al. "High Altitude Reduces Infection Rate of COVID-19 but Not Case-fatality Rate." Respiratory Physiology & Neurobiology, vol. 281, 2020, p. 103494.
Segovia-Juarez J, Castagnetto JM, Gonzales GF. High altitude reduces infection rate of COVID-19 but not case-fatality rate. Respir Physiol Neurobiol. 2020;281:103494.
Segovia-Juarez, J., Castagnetto, J. M., & Gonzales, G. F. (2020). High altitude reduces infection rate of COVID-19 but not case-fatality rate. Respiratory Physiology & Neurobiology, 281, 103494. https://doi.org/10.1016/j.resp.2020.103494
Segovia-Juarez J, Castagnetto JM, Gonzales GF. High Altitude Reduces Infection Rate of COVID-19 but Not Case-fatality Rate. Respir Physiol Neurobiol. 2020;281:103494. PubMed PMID: 32679369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High altitude reduces infection rate of COVID-19 but not case-fatality rate. AU - Segovia-Juarez,Jose, AU - Castagnetto,Jesús M, AU - Gonzales,Gustavo F, Y1 - 2020/07/15/ PY - 2020/06/16/received PY - 2020/07/11/revised PY - 2020/07/12/accepted PY - 2020/7/18/pubmed PY - 2020/9/23/medline PY - 2020/7/18/entrez KW - Altitude KW - COVID-19 KW - Fatality rate KW - Hypoxia SP - 103494 EP - 103494 JF - Respiratory physiology & neurobiology JO - Respir Physiol Neurobiol VL - 281 N2 - Coronavirus disease 19 (COVID-19) is a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is suggested that life at high altitude may reduce COVID-19 infections and case-fatality rates (cases/deaths). We study data from Peru COVID-19 pandemics, which first case was recorded on March 6th, 2020. By June 13, 2020 there were 6498 deaths, and 224,132 SARS-CoV-2 positives. Using data from 185 capitals of provinces with altitudes ranging from 3 to 4342 m, we confirm previous reports that infection with COVID-19 at high altitude is reduced. However, case-fatality rate is not dependent of altitude. We have also presented first evidence that female protection towards death by COVID-19 is reduced as altitude of residence increases. SN - 1878-1519 UR - https://www.unboundmedicine.com/medline/citation/32679369/High_altitude_reduces_infection_rate_of_COVID_19_but_not_case_fatality_rate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-9048(20)30152-X DB - PRIME DP - Unbound Medicine ER -