Tags

Type your tag names separated by a space and hit enter

Modeling the Inactivation of Viruses from the Coronaviridae Family in Response to Temperature and Relative Humidity in Suspensions or on Surfaces.
Appl Environ Microbiol. 2020 09 01; 86(18)AE

Abstract

Temperature and relative humidity are major factors determining virus inactivation in the environment. This article reviews inactivation data regarding coronaviruses on surfaces and in liquids from published studies and develops secondary models to predict coronaviruses inactivation as a function of temperature and relative humidity. A total of 102 D values (i.e., the time to obtain a log10 reduction of virus infectivity), including values for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were collected from 26 published studies. The values obtained from the different coronaviruses and studies were found to be generally consistent. Five different models were fitted to the global data set of D values. The most appropriate model considered temperature and relative humidity. A spreadsheet predicting the inactivation of coronaviruses and the associated uncertainty is presented and can be used to predict virus inactivation for untested temperatures, time points, or any coronavirus strains belonging to Alphacoronavirus and Betacoronavirus genera.IMPORTANCE The prediction of the persistence of SARS-CoV-2 on fomites is essential in investigating the importance of contact transmission. This study collects available information on inactivation kinetics of coronaviruses in both solid and liquid fomites and creates a mathematical model for the impact of temperature and relative humidity on virus persistence. The predictions of the model can support more robust decision-making and could be useful in various public health contexts. A calculator for the natural clearance of SARS-CoV-2 depending on temperature and relative humidity could be a valuable operational tool for public authorities.

Authors+Show Affiliations

Risk Assessment Department, French Agency for Food, Environmental and Occupational Health and Safety, Maisons-Alfort, France laurent.guillier@anses.fr.Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, University of Paris-EST, Maisons-Alfort, France.Risk Assessment Department, French Agency for Food, Environmental and Occupational Health and Safety, Maisons-Alfort, France.Risk Assessment Department, French Agency for Food, Environmental and Occupational Health and Safety, Maisons-Alfort, France.UMR Virologie 1161, ENVA, INRAE, Anses, Maisons-Alfort, France.No affiliation info availableEnvironment and Infectious Risks Unit, Laboratory for Urgent Response to Biological Threats (CIBU), Institut Pasteur, Paris, France.Bacteriology Unit, French Armed Forces Biomedical Research Institute (IRBA), Brétigny-sur-Orge, France.Bacteriology Unit, French Armed Forces Biomedical Research Institute (IRBA), Brétigny-sur-Orge, France.Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA.Risk Assessment Department, French Agency for Food, Environmental and Occupational Health and Safety, Maisons-Alfort, France.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32680860

Citation

Guillier, Laurent, et al. "Modeling the Inactivation of Viruses From the Coronaviridae Family in Response to Temperature and Relative Humidity in Suspensions or On Surfaces." Applied and Environmental Microbiology, vol. 86, no. 18, 2020.
Guillier L, Martin-Latil S, Chaix E, et al. Modeling the Inactivation of Viruses from the Coronaviridae Family in Response to Temperature and Relative Humidity in Suspensions or on Surfaces. Appl Environ Microbiol. 2020;86(18).
Guillier, L., Martin-Latil, S., Chaix, E., Thébault, A., Pavio, N., Le Poder, S., Batéjat, C., Biot, F., Koch, L., Schaffner, D. W., & Sanaa, M. (2020). Modeling the Inactivation of Viruses from the Coronaviridae Family in Response to Temperature and Relative Humidity in Suspensions or on Surfaces. Applied and Environmental Microbiology, 86(18). https://doi.org/10.1128/AEM.01244-20
Guillier L, et al. Modeling the Inactivation of Viruses From the Coronaviridae Family in Response to Temperature and Relative Humidity in Suspensions or On Surfaces. Appl Environ Microbiol. 2020 09 1;86(18) PubMed PMID: 32680860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modeling the Inactivation of Viruses from the Coronaviridae Family in Response to Temperature and Relative Humidity in Suspensions or on Surfaces. AU - Guillier,Laurent, AU - Martin-Latil,Sandra, AU - Chaix,Estelle, AU - Thébault,Anne, AU - Pavio,Nicole, AU - Le Poder,Sophie, AU - Batéjat,Christophe, AU - Biot,Fabrice, AU - Koch,Lionel, AU - Schaffner,Donald W, AU - Sanaa,Moez, AU - ,, Y1 - 2020/09/01/ PY - 2020/05/24/received PY - 2020/07/15/accepted PY - 2020/7/19/pubmed PY - 2020/9/17/medline PY - 2020/7/19/entrez KW - SARS-CoV-2 KW - coronavirus KW - fomites KW - modeling KW - persistence JF - Applied and environmental microbiology JO - Appl Environ Microbiol VL - 86 IS - 18 N2 - Temperature and relative humidity are major factors determining virus inactivation in the environment. This article reviews inactivation data regarding coronaviruses on surfaces and in liquids from published studies and develops secondary models to predict coronaviruses inactivation as a function of temperature and relative humidity. A total of 102 D values (i.e., the time to obtain a log10 reduction of virus infectivity), including values for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were collected from 26 published studies. The values obtained from the different coronaviruses and studies were found to be generally consistent. Five different models were fitted to the global data set of D values. The most appropriate model considered temperature and relative humidity. A spreadsheet predicting the inactivation of coronaviruses and the associated uncertainty is presented and can be used to predict virus inactivation for untested temperatures, time points, or any coronavirus strains belonging to Alphacoronavirus and Betacoronavirus genera.IMPORTANCE The prediction of the persistence of SARS-CoV-2 on fomites is essential in investigating the importance of contact transmission. This study collects available information on inactivation kinetics of coronaviruses in both solid and liquid fomites and creates a mathematical model for the impact of temperature and relative humidity on virus persistence. The predictions of the model can support more robust decision-making and could be useful in various public health contexts. A calculator for the natural clearance of SARS-CoV-2 depending on temperature and relative humidity could be a valuable operational tool for public authorities. SN - 1098-5336 UR - https://www.unboundmedicine.com/medline/citation/32680860/Modeling_the_Inactivation_of_Viruses_from_the_Coronaviridae_Family_in_Response_to_Temperature_and_Relative_Humidity_in_Suspensions_or_on_Surfaces_ L2 - http://aem.asm.org/cgi/pmidlookup?view=long&pmid=32680860 DB - PRIME DP - Unbound Medicine ER -