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SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection.
Sci Immunol. 2020 07 17; 5(49)SI

Abstract

In efforts to synthesize a clear understanding of SARS-CoV-2 protective immunity, antibody analysis has been paralleled by T cell studies across asymptomatic, mild and severe COVID-19. Defining CD4 and CD8 effector functions in protection is important considering that antibody responses appear short-lived and T cell memory is potentially more durable. To fully understand population level immunity, screening for both antibody and T cell immunity using standardized testing methods would be beneficial.

Authors+Show Affiliations

Department of Immunology and Inflammation, Imperial College, London W12 0NN, UK. d.altmann@ic.ac.uk.Department of Infectious Disease, Imperial College, London W12 0NN, UK. Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32680954

Citation

Altmann, Daniel M., and Rosemary J. Boyton. "SARS-CoV-2 T Cell Immunity: Specificity, Function, Durability, and Role in Protection." Science Immunology, vol. 5, no. 49, 2020.
Altmann DM, Boyton RJ. SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection. Sci Immunol. 2020;5(49).
Altmann, D. M., & Boyton, R. J. (2020). SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection. Science Immunology, 5(49). https://doi.org/10.1126/sciimmunol.abd6160
Altmann DM, Boyton RJ. SARS-CoV-2 T Cell Immunity: Specificity, Function, Durability, and Role in Protection. Sci Immunol. 2020 07 17;5(49) PubMed PMID: 32680954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection. AU - Altmann,Daniel M, AU - Boyton,Rosemary J, PY - 2020/07/08/received PY - 2020/07/14/accepted PY - 2020/7/19/entrez PY - 2020/7/19/pubmed PY - 2020/7/28/medline JF - Science immunology JO - Sci Immunol VL - 5 IS - 49 N2 - In efforts to synthesize a clear understanding of SARS-CoV-2 protective immunity, antibody analysis has been paralleled by T cell studies across asymptomatic, mild and severe COVID-19. Defining CD4 and CD8 effector functions in protection is important considering that antibody responses appear short-lived and T cell memory is potentially more durable. To fully understand population level immunity, screening for both antibody and T cell immunity using standardized testing methods would be beneficial. SN - 2470-9468 UR - https://www.unboundmedicine.com/medline/citation/32680954/SARS_CoV_2_T_cell_immunity:_Specificity_function_durability_and_role_in_protection_ L2 - https://immunology.sciencemag.org/cgi/pmidlookup?view=long&pmid=32680954 DB - PRIME DP - Unbound Medicine ER -