Tags

Type your tag names separated by a space and hit enter

α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome.
Sci China Life Sci. 2020 Dec; 63(12):1850-1859.SC

Abstract

The presence of intraneuronal Lewy bodies (LBs) and Lewy neurites (LNs) in the substantia nigra (SN) composed of aggregated α-synuclein (α-syn) has been recognized as a hallmark of pathological changes in Parkinson's disease (PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Wang R
Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases & Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Sun H
Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases & Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Ren H
Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases & Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. rhg@suda.edu.cn.
Wang G
Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases & Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. wanggh@suda.edu.cn.

MeSH

AnimalsCell CommunicationHumansLewy BodiesLysosomesMitochondriaNeuronsParkinson DiseaseProtein Aggregation, Pathologicalalpha-Synuclein

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32681494

Citation

Wang, Rui, et al. "Α-Synuclein Aggregation and Transmission in Parkinson's Disease: a Link to Mitochondria and Lysosome." Science China. Life Sciences, vol. 63, no. 12, 2020, pp. 1850-1859.
Wang R, Sun H, Ren H, et al. Α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome. Sci China Life Sci. 2020;63(12):1850-1859.
Wang, R., Sun, H., Ren, H., & Wang, G. (2020). Α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome. Science China. Life Sciences, 63(12), 1850-1859. https://doi.org/10.1007/s11427-020-1756-9
Wang R, et al. Α-Synuclein Aggregation and Transmission in Parkinson's Disease: a Link to Mitochondria and Lysosome. Sci China Life Sci. 2020;63(12):1850-1859. PubMed PMID: 32681494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome. AU - Wang,Rui, AU - Sun,Hongyang, AU - Ren,Haigang, AU - Wang,Guanghui, Y1 - 2020/07/15/ PY - 2020/04/19/received PY - 2020/06/11/accepted PY - 2020/7/19/pubmed PY - 2021/9/24/medline PY - 2020/7/19/entrez KW - Lewy pathology KW - aggregation KW - lysosome KW - mitochondria KW - transmission KW - α-synuclein SP - 1850 EP - 1859 JF - Science China. Life sciences JO - Sci China Life Sci VL - 63 IS - 12 N2 - The presence of intraneuronal Lewy bodies (LBs) and Lewy neurites (LNs) in the substantia nigra (SN) composed of aggregated α-synuclein (α-syn) has been recognized as a hallmark of pathological changes in Parkinson's disease (PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology. SN - 1869-1889 UR - https://www.unboundmedicine.com/medline/citation/32681494/α_Synuclein_aggregation_and_transmission_in_Parkinson's_disease:_a_link_to_mitochondria_and_lysosome_ DB - PRIME DP - Unbound Medicine ER -