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Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis.
Microb Pathog. 2020 Oct; 147:104390.MP

Abstract

INTRODUCTION

In the current time where we face a COVID-19 pandemic, there is no vaccine or effective treatment at this time. Therefore, the prevention of COVID-19 and the rapid diagnosis of infected patients is crucial.

METHOD

We searched all relevant literature published up to February 28, 2020. We used Random-effect models to analyze the appropriateness of the pooled results.

RESULT

Eighty studies were included in the meta-analysis, including 61,742 patients with confirmed COVID-19 infection. 62.5% (95% CI 54.5-79, p < 0.001) of patients had a history of recent travel endemic area or contact with them. The most common symptoms among COVID-19 infected patients were fever 87% (95% CI 73-93, p < 0.001), and cough 68% (95% CI 55.5-74, p < 0.001)), respectively. The laboratory analysis showed that thrombocytosis was present in 61% (95% CI 41-78, p < 0.001) CRP was elevated in 79% (95% CI 65-91, p < 0.001), and lymphopenia in 57.5% (95% CI 42-79, p < 0.001). The most common radiographic signs were bilateral involvement in 81% (95% CI 62.5-87, p < 0.001), consolidation in 73.5% (95% CI 50.5-91, p < 0.001), and ground-glass opacity 73.5% (95% CI 40-90, p < 0.001) of patients. Case fatality rate (CFR) in <15 years old was 0.6%, in >50 years old was 39.5%, and in all range group was 6%.

CONCLUSIONS

Fever and cough are the most common symptoms of COVID-19 infection in the literature published to date. Thombocytosis, lymphopenia, and increased CRP were common lab findings although most patients included in the overall analysis did not have laboratory values reported. Among Chinese patients with COVID-19, rates of hospitalization, critical condition, and hospitalization were high in this study, but these findings may be biased by reporting only confirmed cases.

Authors+Show Affiliations

Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. Electronic address: pormohammadali@yahoo.com.Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. Electronic address: turnerr@ucalgary.ca.Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mansournia_m@sina.tums.ac.ir.Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.Division of GI, Trauma and Endocrine Surgery, Department of Surgery, University of Colorado, Denver Aurora, Colorado, USA.Division of Infectious Diseases, Department of Medicine, University of Kansas, Kansas City, KS, USA.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32681968

Citation

Pormohammad, Ali, et al. "Clinical Characteristics, Laboratory Findings, Radiographic Signs and Outcomes of 61,742 Patients With Confirmed COVID-19 Infection: a Systematic Review and Meta-analysis." Microbial Pathogenesis, vol. 147, 2020, p. 104390.
Pormohammad A, Ghorbani S, Baradaran B, et al. Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis. Microb Pathog. 2020;147:104390.
Pormohammad, A., Ghorbani, S., Baradaran, B., Khatami, A., J Turner, R., Mansournia, M. A., Kyriacou, D. N., Idrovo, J. P., & Bahr, N. C. (2020). Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis. Microbial Pathogenesis, 147, 104390. https://doi.org/10.1016/j.micpath.2020.104390
Pormohammad A, et al. Clinical Characteristics, Laboratory Findings, Radiographic Signs and Outcomes of 61,742 Patients With Confirmed COVID-19 Infection: a Systematic Review and Meta-analysis. Microb Pathog. 2020;147:104390. PubMed PMID: 32681968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis. AU - Pormohammad,Ali, AU - Ghorbani,Saied, AU - Baradaran,Behzad, AU - Khatami,Alireza, AU - J Turner,Raymond, AU - Mansournia,Mohammad Ali, AU - Kyriacou,Demetrios N, AU - Idrovo,Juan-Pablo, AU - Bahr,Nathan C, Y1 - 2020/07/15/ PY - 2020/04/18/received PY - 2020/06/02/revised PY - 2020/07/06/accepted PY - 2020/7/19/pubmed PY - 2020/10/2/medline PY - 2020/7/19/entrez KW - COVID-19 KW - Coronavirus KW - SARS-CoV-2 KW - Severe acute respiratory syndrome coronavirus KW - meta-Analysis SP - 104390 EP - 104390 JF - Microbial pathogenesis JO - Microb Pathog VL - 147 N2 - INTRODUCTION: In the current time where we face a COVID-19 pandemic, there is no vaccine or effective treatment at this time. Therefore, the prevention of COVID-19 and the rapid diagnosis of infected patients is crucial. METHOD: We searched all relevant literature published up to February 28, 2020. We used Random-effect models to analyze the appropriateness of the pooled results. RESULT: Eighty studies were included in the meta-analysis, including 61,742 patients with confirmed COVID-19 infection. 62.5% (95% CI 54.5-79, p < 0.001) of patients had a history of recent travel endemic area or contact with them. The most common symptoms among COVID-19 infected patients were fever 87% (95% CI 73-93, p < 0.001), and cough 68% (95% CI 55.5-74, p < 0.001)), respectively. The laboratory analysis showed that thrombocytosis was present in 61% (95% CI 41-78, p < 0.001) CRP was elevated in 79% (95% CI 65-91, p < 0.001), and lymphopenia in 57.5% (95% CI 42-79, p < 0.001). The most common radiographic signs were bilateral involvement in 81% (95% CI 62.5-87, p < 0.001), consolidation in 73.5% (95% CI 50.5-91, p < 0.001), and ground-glass opacity 73.5% (95% CI 40-90, p < 0.001) of patients. Case fatality rate (CFR) in <15 years old was 0.6%, in >50 years old was 39.5%, and in all range group was 6%. CONCLUSIONS: Fever and cough are the most common symptoms of COVID-19 infection in the literature published to date. Thombocytosis, lymphopenia, and increased CRP were common lab findings although most patients included in the overall analysis did not have laboratory values reported. Among Chinese patients with COVID-19, rates of hospitalization, critical condition, and hospitalization were high in this study, but these findings may be biased by reporting only confirmed cases. SN - 1096-1208 UR - https://www.unboundmedicine.com/medline/citation/32681968/Clinical_characteristics_laboratory_findings_radiographic_signs_and_outcomes_of_61742_patients_with_confirmed_COVID_19_infection:_A_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0882-4010(20)30756-7 DB - PRIME DP - Unbound Medicine ER -