Tags

Type your tag names separated by a space and hit enter

Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry.
Cardiovasc Diabetol. 2020 07 18; 19(1):113.CD

Abstract

BACKGROUND

The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA).

METHODS

A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year.

RESULTS

The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0-20.2), group II: 7.6 (0.5-23.5), and group III: 9.4 (1.4-27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167-2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288-2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors.

CONCLUSION

TyG index is an independent predictive marker for the progression of coronary atherosclerosis. Clinical registration ClinicalTrials.gov NCT02803411.

Authors+Show Affiliations

Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea. Department of Cardiology, Severance Cardiovascular Hospital, Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.Department of Cardiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. Department of Cardiology, Catholic Kwandong University International St. Mary's Hospital, Incheon, South Korea.Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. Department of Cardiology, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, South Korea.Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. Department of Cardiology, Ewha Womans University Medical Center, Seoul, South Korea.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA. Department of Radiology, Mayo Clinic, Rochester, MN, USA.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA.Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, Germany.Department of Cardiology, Seoul National University Hospital, Seoul, South Korea.Department of Cardiology, Severance Cardiovascular Hospital, Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea.Centro Cardiologico Monzino, IRCCS, Milan, Italy.Centro Cardiologico Monzino, IRCCS, Milan, Italy.Centro Cardiologico Monzino, IRCCS, Milan, Italy.Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, CA, USA.Department of Radiology, Casa de Saude São Jose, Rio de Janeiro, Brazil.Department of Radiology, Seoul National University Bundang Hospital, Sungnam, South Korea.Cardiovascular Imaging Center, SDN IRCCS, Naples, Italy.Department of Radiology, Area Vasta 1/ASUR, Marche, Urbino, Italy.UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisbon, Portugal.UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisbon, Portugal.Department of Medicine and Radiology, University of British Columbia, Vancouver, BC, Canada.Department of Cardiology, Ewha Womans University Medical Center, Seoul, South Korea.Department of Cardiology, Busan University Hospital, Busan, South Korea.Department of Pathology, CVPath Institute, Gaithersburg, MD, USA.Department of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.Department of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA.Department of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA.Department of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.Department of Imaging and Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.Icahn School of Medicine at Mount Sinai, Mount Sinai Heart, New York, USA. Zena and Michael A. Wiener Cardiovascular Institute, and Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, New York, NY, USA.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA.Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA.Department of Cardiology, Severance Cardiovascular Hospital, Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. hjchang@yuhs.ac. Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. hjchang@yuhs.ac.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32682451

Citation

Won, Ki-Bum, et al. "Quantitative Assessment of Coronary Plaque Volume Change Related to Triglyceride Glucose Index: the Progression of AtheRosclerotic PlAque DetermIned By Computed TomoGraphic Angiography IMaging (PARADIGM) Registry." Cardiovascular Diabetology, vol. 19, no. 1, 2020, p. 113.
Won KB, Lee BK, Park HB, et al. Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. Cardiovasc Diabetol. 2020;19(1):113.
Won, K. B., Lee, B. K., Park, H. B., Heo, R., Lee, S. E., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y. J., Sung, J. M., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Chun, E. J., Cademartiri, F., Maffei, E., ... Chang, H. J. (2020). Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. Cardiovascular Diabetology, 19(1), 113. https://doi.org/10.1186/s12933-020-01081-w
Won KB, et al. Quantitative Assessment of Coronary Plaque Volume Change Related to Triglyceride Glucose Index: the Progression of AtheRosclerotic PlAque DetermIned By Computed TomoGraphic Angiography IMaging (PARADIGM) Registry. Cardiovasc Diabetol. 2020 07 18;19(1):113. PubMed PMID: 32682451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. AU - Won,Ki-Bum, AU - Lee,Byoung Kwon, AU - Park,Hyung-Bok, AU - Heo,Ran, AU - Lee,Sang-Eun, AU - Rizvi,Asim, AU - Lin,Fay Y, AU - Kumar,Amit, AU - Hadamitzky,Martin, AU - Kim,Yong-Jin, AU - Sung,Ji Min, AU - Conte,Edoardo, AU - Andreini,Daniele, AU - Pontone,Gianluca, AU - Budoff,Matthew J, AU - Gottlieb,Ilan, AU - Chun,Eun Ju, AU - Cademartiri,Filippo, AU - Maffei,Erica, AU - Marques,Hugo, AU - de Araújo Gonçalves,Pedro, AU - Leipsic,Jonathon A, AU - Shin,Sanghoon, AU - Choi,Jung Hyun, AU - Virmani,Renu, AU - Samady,Habib, AU - Chinnaiyan,Kavitha, AU - Raff,Gilbert L, AU - Stone,Peter H, AU - Berman,Daniel S, AU - Narula,Jagat, AU - Shaw,Leslee J, AU - Bax,Jeroen J, AU - Min,James K, AU - Chang,Hyuk-Jae, Y1 - 2020/07/18/ PY - 2020/04/24/received PY - 2020/07/02/accepted PY - 2020/7/20/entrez PY - 2020/7/20/pubmed PY - 2021/5/18/medline KW - Atherosclerosis KW - Coronary artery disease KW - Coronary computed tomography angiography KW - Triglyceride glucose index SP - 113 EP - 113 JF - Cardiovascular diabetology JO - Cardiovasc Diabetol VL - 19 IS - 1 N2 - BACKGROUND: The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). METHODS: A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year. RESULTS: The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0-20.2), group II: 7.6 (0.5-23.5), and group III: 9.4 (1.4-27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167-2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288-2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors. CONCLUSION: TyG index is an independent predictive marker for the progression of coronary atherosclerosis. Clinical registration ClinicalTrials.gov NCT02803411. SN - 1475-2840 UR - https://www.unboundmedicine.com/medline/citation/32682451/Quantitative_assessment_of_coronary_plaque_volume_change_related_to_triglyceride_glucose_index:_The_Progression_of_AtheRosclerotic_PlAque_DetermIned_by_Computed_TomoGraphic_Angiography_IMaging__PARADIGM__registry_ L2 - https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-01081-w DB - PRIME DP - Unbound Medicine ER -