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Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness.
Indian Pediatr. 2020 Oct 15; 57(10):929-935.IP

Abstract

The pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS). Features of this newly recognized condition may include persistent fever, evidence of inflammation, and single or multi-organ dysfunction in the absence of other known infections. Some of these children may share features of Kawasaki disease, toxic shock syndrome or cytokine storm syndrome. They can deteriorate rapidly and may need intensive care support as well. The PCR test is more often negative; although, most of the children have antibodies to SARS-CoV-2. Although the pathogenesis is not clearly known, immune-mediated injury has been implicated. We herein provide current information on this condition, in order to raise awareness amongst pediatricians.

Authors+Show Affiliations

Pediatric Rheumatology Service, Rainbow Children's Hospital, Bangalore, Karnataka, India. Correspondence: Dr Chandrika S Bhat, Rainbow Children's Hospital, Marathahalli, Bengaluru 560 037, Karnataka, India.Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh India.Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.Bristol Royal Hospital for Children and Translational Health Sciences, University of Bristol, Bristol, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32683336

Citation

Bhat, Chandrika S., et al. "Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness." Indian Pediatrics, vol. 57, no. 10, 2020, pp. 929-935.
Bhat CS, Gupta L, Balasubramanian S, et al. Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness. Indian Pediatr. 2020;57(10):929-935.
Bhat, C. S., Gupta, L., Balasubramanian, S., Singh, S., & Ramanan, A. V. (2020). Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness. Indian Pediatrics, 57(10), 929-935.
Bhat CS, et al. Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness. Indian Pediatr. 2020 Oct 15;57(10):929-935. PubMed PMID: 32683336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness. AU - Bhat,Chandrika S, AU - Gupta,Latika, AU - Balasubramanian,S, AU - Singh,Surjit, AU - Ramanan,Athimalaipet V, Y1 - 2020/07/15/ PY - 2020/7/20/pubmed PY - 2020/11/5/medline PY - 2020/7/20/entrez SP - 929 EP - 935 JF - Indian pediatrics JO - Indian Pediatr VL - 57 IS - 10 N2 - The pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS). Features of this newly recognized condition may include persistent fever, evidence of inflammation, and single or multi-organ dysfunction in the absence of other known infections. Some of these children may share features of Kawasaki disease, toxic shock syndrome or cytokine storm syndrome. They can deteriorate rapidly and may need intensive care support as well. The PCR test is more often negative; although, most of the children have antibodies to SARS-CoV-2. Although the pathogenesis is not clearly known, immune-mediated injury has been implicated. We herein provide current information on this condition, in order to raise awareness amongst pediatricians. SN - 0974-7559 UR - https://www.unboundmedicine.com/medline/citation/32683336/Hyperinflammatory_Syndrome_in_Children_Associated_With_COVID_19:_Need_for_Awareness_ L2 - https://www.indianpediatrics.net/COVID29.03.2020/SA-00208.pdf DB - PRIME DP - Unbound Medicine ER -