Tags

Type your tag names separated by a space and hit enter

Prospective Study in 355 Patients With Suspected COVID-19 Infection: Value of Cough, Subjective Hyposmia, and Hypogeusia.
Laryngoscope. 2020 11; 130(11):2674-2679.L

Abstract

OBJECTIVE

To evaluate the incidence of certain symptoms in a population of health workers exposed to coronavirus disease 2019 patients.

STUDY DESIGN

Case-control study.

METHODS

The study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected coronavirus disease 2019 (COVID-19) infection were included. The presence of COVID-19 was detected by using real-time polymerase chain reaction (RT-PCR) methods. Positive and negative RT-PCR patients were used as case and control groups, respectively. This study analyzed the incidence of COVID-19 symptoms in both patient groups. Visual analog scales were used for self-assessment of smell and taste disorders, ranging from 0 (no perception) to 10 (excellent perception).

RESULTS

There were 215 (60.6%) patients with positive RT-PCR and 140 (39.4%) patients with negative RT-PCR. The presence of symptoms such as hyposmia hypogeusia, dysthermia, and cough were strongly associated with a positive RT-PCR. The association of cough and subjective hyposmia had 5.46 times higher odds of having a positive test. The receiver operating characteristic (ROC) analysis showed that a fever higher than 37.45°C resulted in sensitivity and specificity of 0.65 and 0.61, respectively. A total of 138 cases (64.1%) and 114 cases (53%) had subjective hyposmia and hypogeusia, respectively. The 85.4% of these patients recovered olfactory function within the first 14 days of the onset of the symptoms.

CONCLUSION

There is a significant association between positive RT-PCR and subjective hyposmia. The association of subjective hyposmia and cough increase significantly the odds of having a positive RT-PCR. The measurement of fever as the only method for screening of COVID-19 infection resulted in a poor association.

LEVEL OF EVIDENCE

3 Laryngoscope, 130:2674-2679, 2020.

Authors+Show Affiliations

Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32686164

Citation

Martin-Sanz, Eduardo, et al. "Prospective Study in 355 Patients With Suspected COVID-19 Infection: Value of Cough, Subjective Hyposmia, and Hypogeusia." The Laryngoscope, vol. 130, no. 11, 2020, pp. 2674-2679.
Martin-Sanz E, Riestra J, Yebra L, et al. Prospective Study in 355 Patients With Suspected COVID-19 Infection: Value of Cough, Subjective Hyposmia, and Hypogeusia. Laryngoscope. 2020;130(11):2674-2679.
Martin-Sanz, E., Riestra, J., Yebra, L., Larran, A., Mancino, F., Yanes-Diaz, J., Garrote, M., Colmenero, M., Montiel, E., Molina, C., Moreno, D., Rodriguez, A., Monedero, G., Sanz-Fernández, R., Gonzalez, R., & Esteban-Sanchez, J. (2020). Prospective Study in 355 Patients With Suspected COVID-19 Infection: Value of Cough, Subjective Hyposmia, and Hypogeusia. The Laryngoscope, 130(11), 2674-2679. https://doi.org/10.1002/lary.28999
Martin-Sanz E, et al. Prospective Study in 355 Patients With Suspected COVID-19 Infection: Value of Cough, Subjective Hyposmia, and Hypogeusia. Laryngoscope. 2020;130(11):2674-2679. PubMed PMID: 32686164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective Study in 355 Patients With Suspected COVID-19 Infection: Value of Cough, Subjective Hyposmia, and Hypogeusia. AU - Martin-Sanz,Eduardo, AU - Riestra,Juan, AU - Yebra,Laura, AU - Larran,Alba, AU - Mancino,Fiorella, AU - Yanes-Diaz,Joaquin, AU - Garrote,Maria, AU - Colmenero,Marta, AU - Montiel,Esther, AU - Molina,Cristina, AU - Moreno,Daniel, AU - Rodriguez,Antonio, AU - Monedero,Gerardo, AU - Sanz-Fernández,Ricardo, AU - Gonzalez,Rocio, AU - Esteban-Sanchez,Jonathan, Y1 - 2020/08/17/ PY - 2020/04/23/received PY - 2020/07/14/revised PY - 2020/07/16/accepted PY - 2020/7/21/pubmed PY - 2020/12/22/medline PY - 2020/7/21/entrez KW - Hyposmia, hypogeusia, COVID-19, odds ratio, incidence, ROC SP - 2674 EP - 2679 JF - The Laryngoscope JO - Laryngoscope VL - 130 IS - 11 N2 - OBJECTIVE: To evaluate the incidence of certain symptoms in a population of health workers exposed to coronavirus disease 2019 patients. STUDY DESIGN: Case-control study. METHODS: The study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected coronavirus disease 2019 (COVID-19) infection were included. The presence of COVID-19 was detected by using real-time polymerase chain reaction (RT-PCR) methods. Positive and negative RT-PCR patients were used as case and control groups, respectively. This study analyzed the incidence of COVID-19 symptoms in both patient groups. Visual analog scales were used for self-assessment of smell and taste disorders, ranging from 0 (no perception) to 10 (excellent perception). RESULTS: There were 215 (60.6%) patients with positive RT-PCR and 140 (39.4%) patients with negative RT-PCR. The presence of symptoms such as hyposmia hypogeusia, dysthermia, and cough were strongly associated with a positive RT-PCR. The association of cough and subjective hyposmia had 5.46 times higher odds of having a positive test. The receiver operating characteristic (ROC) analysis showed that a fever higher than 37.45°C resulted in sensitivity and specificity of 0.65 and 0.61, respectively. A total of 138 cases (64.1%) and 114 cases (53%) had subjective hyposmia and hypogeusia, respectively. The 85.4% of these patients recovered olfactory function within the first 14 days of the onset of the symptoms. CONCLUSION: There is a significant association between positive RT-PCR and subjective hyposmia. The association of subjective hyposmia and cough increase significantly the odds of having a positive RT-PCR. The measurement of fever as the only method for screening of COVID-19 infection resulted in a poor association. LEVEL OF EVIDENCE: 3 Laryngoscope, 130:2674-2679, 2020. SN - 1531-4995 UR - https://www.unboundmedicine.com/medline/citation/32686164/Prospective_Study_in_355_Patients_With_Suspected_COVID_19_Infection:_Value_of_Cough_Subjective_Hyposmia_and_Hypogeusia_ DB - PRIME DP - Unbound Medicine ER -