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Acute Kidney Injury and Kidney Damage in COVID-19 Patients.
J Korean Med Sci. 2020 Jul 20; 35(28):e257.JK

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This disease, which is quickly spreading worldwide, has high potential for infection and causes rapid progression of lung lesions, resulting in a high mortality rate. This study aimed to investigate the effects of SARS-CoV-2 infection on renal function in patients with COVID-19.

METHODS

From February 21 to April 24, 2020, 66 patients diagnosed with COVID-19 at Chungnam National University Hospital were analyzed; all patients underwent routine urinalysis and were tested for serum creatinine, urine protein to creatinine ratio (PCR), and urine albumin to creatinine ratio (ACR).

RESULTS

Acute kidney injury (AKI) occurred in 3 (4.5%) of the 66 patients, and 1 patient with AKI stage 3 underwent hemodialysis. Upon follow-up, all 3 patients recovered normal renal function. Compared with patients with mild COVID-19, AKI (n = 3) occurred in patients with severe COVID-19, of whom both urine PCR and ACR were markedly increased.

CONCLUSION

The incidence of AKI was not high in COVID-19 patients. The lower mortality rate in SARS-CoV-2 infection compared with previous Middle East respiratory syndrome and SARS-CoV infections is thought to be associated with a low incidence of dysfunction in organs other than the lungs.

Links

Publisher Full Text
ncbi.nlm.nih.gov
jkms.org
PMC Free PDF

Authors+Show Affiliations

Na KR
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Nephrology, Chungnam National University Hospital, Daejeon, Korea.
Kim HR
Department of Nephrology, Chungnam National University Sejong Hospital, Sejong, Korea.
Ham Y
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Nephrology, Chungnam National University Hospital, Daejeon, Korea.
Choi DE
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Nephrology, Chungnam National University Hospital, Daejeon, Korea.
Lee KW
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Nephrology, Chungnam National University Hospital, Daejeon, Korea.
Moon JY
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Pulmonary and Critical Care Medicine, Chungnam National University Sejong Hospital, Sejong, Korea.
Kim YS
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Infectious Disease, Chungnam National University Hospital, Daejeon, Korea.
Cheon S
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Infectious Disease, Chungnam National University Hospital, Daejeon, Korea.
Sohn KM
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Infectious Disease, Chungnam National University Hospital, Daejeon, Korea.
Kim J
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Infectious Disease, Chungnam National University Sejong Hospital, Sejong, Korea.
Kim S
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Infectious Disease, Chungnam National University Sejong Hospital, Sejong, Korea.
Jeong H
Department of Infectious Disease, Chungnam National University Hospital, Daejeon, Korea.
Jeon JW
Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. Department of Nephrology, Chungnam National University Sejong Hospital, Sejong, Korea. wanjazzang@hanmail.net.

MeSH

Acute Kidney InjuryAgedAlbuminsAlbuminuriaBetacoronavirusCOVID-19Coronavirus InfectionsCreatinineFemaleGlomerular Filtration RateHumansKidney Function TestsMaleMiddle AgedPandemicsPneumonia, ViralProteinuriaRepublic of KoreaSARS-CoV-2

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32686373

Citation

Na, Ki Ryang, et al. "Acute Kidney Injury and Kidney Damage in COVID-19 Patients." Journal of Korean Medical Science, vol. 35, no. 28, 2020, pp. e257.
Na KR, Kim HR, Ham Y, et al. Acute Kidney Injury and Kidney Damage in COVID-19 Patients. J Korean Med Sci. 2020;35(28):e257.
Na, K. R., Kim, H. R., Ham, Y., Choi, D. E., Lee, K. W., Moon, J. Y., Kim, Y. S., Cheon, S., Sohn, K. M., Kim, J., Kim, S., Jeong, H., & Jeon, J. W. (2020). Acute Kidney Injury and Kidney Damage in COVID-19 Patients. Journal of Korean Medical Science, 35(28), e257. https://doi.org/10.3346/jkms.2020.35.e257
Na KR, et al. Acute Kidney Injury and Kidney Damage in COVID-19 Patients. J Korean Med Sci. 2020 Jul 20;35(28):e257. PubMed PMID: 32686373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute Kidney Injury and Kidney Damage in COVID-19 Patients. AU - Na,Ki Ryang, AU - Kim,Hae Ri, AU - Ham,Youngrok, AU - Choi,Dae Eun, AU - Lee,Kang Wook, AU - Moon,Jae Young, AU - Kim,Yeon Sook, AU - Cheon,Shinhye, AU - Sohn,Kyung Mok, AU - Kim,Jungok, AU - Kim,Sungmin, AU - Jeong,Hyeongseok, AU - Jeon,Jae Wan, Y1 - 2020/07/20/ PY - 2020/05/11/received PY - 2020/06/30/accepted PY - 2020/7/21/entrez PY - 2020/7/21/pubmed PY - 2020/7/28/medline KW - Acute Kidney Injury KW - COVID-19 KW - Coronavirus Disease 2019 KW - Proteinuria KW - SARS-CoV-2 KW - Severe Acute Respiratory Syndrome Coronavirus 2 SP - e257 EP - e257 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 35 IS - 28 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This disease, which is quickly spreading worldwide, has high potential for infection and causes rapid progression of lung lesions, resulting in a high mortality rate. This study aimed to investigate the effects of SARS-CoV-2 infection on renal function in patients with COVID-19. METHODS: From February 21 to April 24, 2020, 66 patients diagnosed with COVID-19 at Chungnam National University Hospital were analyzed; all patients underwent routine urinalysis and were tested for serum creatinine, urine protein to creatinine ratio (PCR), and urine albumin to creatinine ratio (ACR). RESULTS: Acute kidney injury (AKI) occurred in 3 (4.5%) of the 66 patients, and 1 patient with AKI stage 3 underwent hemodialysis. Upon follow-up, all 3 patients recovered normal renal function. Compared with patients with mild COVID-19, AKI (n = 3) occurred in patients with severe COVID-19, of whom both urine PCR and ACR were markedly increased. CONCLUSION: The incidence of AKI was not high in COVID-19 patients. The lower mortality rate in SARS-CoV-2 infection compared with previous Middle East respiratory syndrome and SARS-CoV infections is thought to be associated with a low incidence of dysfunction in organs other than the lungs. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/32686373/Acute_Kidney_Injury_and_Kidney_Damage_in_COVID_19_Patients_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e257 DB - PRIME DP - Unbound Medicine ER -