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Neuropathogenic human coronaviruses: A review.
Rev Med Virol. 2020 09; 30(5):e2118.RM

Abstract

Human Coronaviruses (HCoVs) have long been known as respiratory viruses. However, there are reports of neurological findings in HCoV infections, particularly in patients infected with the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) amid Coronavirus disease 2019 (COVID-19) pandemic. Therefore, it is essential to interpret the interaction of HCoVs and the nervous system and apply this understanding to the COVID-19 pandemic. This review of the literature analyses how HCoVs, in general, and SARS-CoV-2, in particular, affect the nervous system, highlights the various underlying mechanisms, addresses the associated neurological and psychiatric manifestations, and identifies the neurological risk factors involved. This review of literature shows the magnitude of neurological conditions associated with HCoV infections, including SARS-CoV-2. This review emphasises, that, during HCoV outbreaks, such as COVID-19, a focus on early detection of neurotropism, alertness for the resulting neurological complications, and the recognition of neurological risk factors are crucial to reduce the workload on hospitals, particularly intensive-care units and neurological departments.

Authors+Show Affiliations

Neurosurgery Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.Neurosurgery Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32687681

Citation

Abdelaziz, Osama S., and Zuraiha Waffa. "Neuropathogenic Human Coronaviruses: a Review." Reviews in Medical Virology, vol. 30, no. 5, 2020, pp. e2118.
Abdelaziz OS, Waffa Z. Neuropathogenic human coronaviruses: A review. Rev Med Virol. 2020;30(5):e2118.
Abdelaziz, O. S., & Waffa, Z. (2020). Neuropathogenic human coronaviruses: A review. Reviews in Medical Virology, 30(5), e2118. https://doi.org/10.1002/rmv.2118
Abdelaziz OS, Waffa Z. Neuropathogenic Human Coronaviruses: a Review. Rev Med Virol. 2020;30(5):e2118. PubMed PMID: 32687681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropathogenic human coronaviruses: A review. AU - Abdelaziz,Osama S, AU - Waffa,Zuraiha, Y1 - 2020/07/20/ PY - 2020/04/18/received PY - 2020/05/06/revised PY - 2020/05/07/accepted PY - 2020/7/21/pubmed PY - 2020/10/2/medline PY - 2020/7/21/entrez KW - COVID-19 KW - SARS-CoV-2 KW - autopsy KW - brain KW - human coronavirus KW - nervous system KW - neuroinvasion SP - e2118 EP - e2118 JF - Reviews in medical virology JO - Rev Med Virol VL - 30 IS - 5 N2 - Human Coronaviruses (HCoVs) have long been known as respiratory viruses. However, there are reports of neurological findings in HCoV infections, particularly in patients infected with the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) amid Coronavirus disease 2019 (COVID-19) pandemic. Therefore, it is essential to interpret the interaction of HCoVs and the nervous system and apply this understanding to the COVID-19 pandemic. This review of the literature analyses how HCoVs, in general, and SARS-CoV-2, in particular, affect the nervous system, highlights the various underlying mechanisms, addresses the associated neurological and psychiatric manifestations, and identifies the neurological risk factors involved. This review of literature shows the magnitude of neurological conditions associated with HCoV infections, including SARS-CoV-2. This review emphasises, that, during HCoV outbreaks, such as COVID-19, a focus on early detection of neurotropism, alertness for the resulting neurological complications, and the recognition of neurological risk factors are crucial to reduce the workload on hospitals, particularly intensive-care units and neurological departments. SN - 1099-1654 UR - https://www.unboundmedicine.com/medline/citation/32687681/Neuropathogenic_human_coronaviruses:_A_review_ L2 - https://doi.org/10.1002/rmv.2118 DB - PRIME DP - Unbound Medicine ER -