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Decontaminating N95 and SN95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety.
J Hosp Infect. 2020 Sep; 106(1):163-175.JH

Abstract

Inadequate supply of filtering facepiece respirators (FFRs) for healthcare workers during a pandemic such as the novel coronavirus outbreak (SARS-CoV-2) is a serious public health issue. The aim of this study was to synthesize existing data on the effectiveness of ultraviolet germicidal irradiation (UVGI) for N95 FFR decontamination. A systematic review (PROSPERO CRD42020176156) was conducted on UVGI in N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined eligibility and extracted predefined variables. Original research reporting on function, decontamination, or mask fit following UVGI were included. Thirteen studies were identified, comprising 54 UVGI intervention arms and 58 N95 models. FFRs consistently maintained certification standards following UVGI. Aerosol penetration averaged 1.19% (0.70-2.48%) and 1.14% (0.57-2.63%) for control and UVGI arms, respectively. Airflow resistance for the control arms averaged 9.79 mm H2O (7.97-11.70 mm H2O) vs 9.85 mm H2O (8.33-11.44 mm H2O) for UVGI arms. UVGI protocols employing a cumulative dose >20,000 J/m2 resulted in a 2-log reduction in viral load. A >3-log reduction was observed in seven UVGI arms using >40,000 J/m2. Impact of UVGI on fit was evaluated in two studies (16,200; 32,400 J/m2) and no evidence of compromise was found. Our findings suggest that further work in this area (or translation to a clinical setting) should use a cumulative UV-C dose of 40,000 J/m2 or greater, and confirm appropriate mask fit following decontamination.

Authors+Show Affiliations

Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.Library Services, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.Clinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.Clinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.Department of Biology, University of Ottawa, Ottawa, ON, Canada.Health Sciences Library, University of Ottawa, Ottawa, ON, Canada.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. Electronic address: dmcnally@cheo.on.ca.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32687870

Citation

O'Hearn, K, et al. "Decontaminating N95 and SN95 Masks With Ultraviolet Germicidal Irradiation Does Not Impair Mask Efficacy and Safety." The Journal of Hospital Infection, vol. 106, no. 1, 2020, pp. 163-175.
O'Hearn K, Gertsman S, Sampson M, et al. Decontaminating N95 and SN95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety. J Hosp Infect. 2020;106(1):163-175.
O'Hearn, K., Gertsman, S., Sampson, M., Webster, R., Tsampalieros, A., Ng, R., Gibson, J., Lobos, A. T., Acharya, N., Agarwal, A., Boggs, S., Chamberlain, G., Staykov, E., Sikora, L., & McNally, J. D. (2020). Decontaminating N95 and SN95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety. The Journal of Hospital Infection, 106(1), 163-175. https://doi.org/10.1016/j.jhin.2020.07.014
O'Hearn K, et al. Decontaminating N95 and SN95 Masks With Ultraviolet Germicidal Irradiation Does Not Impair Mask Efficacy and Safety. J Hosp Infect. 2020;106(1):163-175. PubMed PMID: 32687870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decontaminating N95 and SN95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety. AU - O'Hearn,K, AU - Gertsman,S, AU - Sampson,M, AU - Webster,R, AU - Tsampalieros,A, AU - Ng,R, AU - Gibson,J, AU - Lobos,A T, AU - Acharya,N, AU - Agarwal,A, AU - Boggs,S, AU - Chamberlain,G, AU - Staykov,E, AU - Sikora,L, AU - McNally,J D, Y1 - 2020/07/18/ PY - 2020/04/11/received PY - 2020/07/13/accepted PY - 2020/7/21/pubmed PY - 2020/7/21/medline PY - 2020/7/21/entrez KW - Decontamination KW - Masks KW - N95 KW - PPE KW - UVGI SP - 163 EP - 175 JF - The Journal of hospital infection JO - J. Hosp. Infect. VL - 106 IS - 1 N2 - Inadequate supply of filtering facepiece respirators (FFRs) for healthcare workers during a pandemic such as the novel coronavirus outbreak (SARS-CoV-2) is a serious public health issue. The aim of this study was to synthesize existing data on the effectiveness of ultraviolet germicidal irradiation (UVGI) for N95 FFR decontamination. A systematic review (PROSPERO CRD42020176156) was conducted on UVGI in N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined eligibility and extracted predefined variables. Original research reporting on function, decontamination, or mask fit following UVGI were included. Thirteen studies were identified, comprising 54 UVGI intervention arms and 58 N95 models. FFRs consistently maintained certification standards following UVGI. Aerosol penetration averaged 1.19% (0.70-2.48%) and 1.14% (0.57-2.63%) for control and UVGI arms, respectively. Airflow resistance for the control arms averaged 9.79 mm H2O (7.97-11.70 mm H2O) vs 9.85 mm H2O (8.33-11.44 mm H2O) for UVGI arms. UVGI protocols employing a cumulative dose >20,000 J/m2 resulted in a 2-log reduction in viral load. A >3-log reduction was observed in seven UVGI arms using >40,000 J/m2. Impact of UVGI on fit was evaluated in two studies (16,200; 32,400 J/m2) and no evidence of compromise was found. Our findings suggest that further work in this area (or translation to a clinical setting) should use a cumulative UV-C dose of 40,000 J/m2 or greater, and confirm appropriate mask fit following decontamination. SN - 1532-2939 UR - https://www.unboundmedicine.com/medline/citation/32687870/Decontaminating_N95_and_SN95_masks_with_ultraviolet_germicidal_irradiation_does_not_impair_mask_efficacy_and_safety_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0195-6701(20)30345-5 DB - PRIME DP - Unbound Medicine ER -