Tags

Type your tag names separated by a space and hit enter

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions.
Life Sci. 2020 Sep 15; 257:118102.LS

Abstract

The COVID-19-, SARS- and MERS-related coronaviruses share many genomic and structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and MERS-CoV. Despite some differences in the cytokine patterns, it seems that the cytokine storm plays a crucial role in the pathogenesis of COVID-19-, SARS- and MERS. Monocytes and macrophages may be infected by SARS-CoV-2 through ACE2-dependent and ACE2-independent pathways. SARS-CoV-2 can effectively suppress the anti-viral IFN response in monocytes and macrophages. Since macrophages and dendritic cells (DCs) act as antigen presenting cells (APCs), the infection of these cells by SARS-CoV-2 impairs the adaptive immune responses against the virus. Upon infection, monocytes migrate to the tissues where they become infected resident macrophages, allowing viruses to spread through all organs and tissues. The SARS-CoV-2-infected monocytes and macrophages can produce large amounts of numerous types of pro-inflammatory cytokines and chemokines, which contribute to local tissue inflammation and a dangerous systemic inflammatory response called cytokine storm. Both local tissue inflammation and the cytokine storm play a fundamental role in the development of COVID-19-related complications, such as acute respiratory distress syndrome (ARDS), which is a main cause of death in COVID-19 patients. Here, we describe the monocytes and macrophage responses during severe coronavirus infections, while highlighting potential therapeutic interventions to attenuate macrophage-related inflammatory reactions in possible approaches for COVID-19 treatment.

Authors+Show Affiliations

Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Electronic address: Jafarzadeh14@yahoo.com.National Centre For Cell Science, Pune 411007, India.National Centre For Cell Science, Pune 411007, India; Trident Academy of Creative Technology, Bhubaneswar, India.Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Haematology and Laboratory Sciences, School of Para-Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32687918

Citation

Jafarzadeh, Abdollah, et al. "Contribution of Monocytes and Macrophages to the Local Tissue Inflammation and Cytokine Storm in COVID-19: Lessons From SARS and MERS, and Potential Therapeutic Interventions." Life Sciences, vol. 257, 2020, p. 118102.
Jafarzadeh A, Chauhan P, Saha B, et al. Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions. Life Sci. 2020;257:118102.
Jafarzadeh, A., Chauhan, P., Saha, B., Jafarzadeh, S., & Nemati, M. (2020). Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions. Life Sciences, 257, 118102. https://doi.org/10.1016/j.lfs.2020.118102
Jafarzadeh A, et al. Contribution of Monocytes and Macrophages to the Local Tissue Inflammation and Cytokine Storm in COVID-19: Lessons From SARS and MERS, and Potential Therapeutic Interventions. Life Sci. 2020 Sep 15;257:118102. PubMed PMID: 32687918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions. AU - Jafarzadeh,Abdollah, AU - Chauhan,Prashant, AU - Saha,Bhaskar, AU - Jafarzadeh,Sara, AU - Nemati,Maryam, Y1 - 2020/07/18/ PY - 2020/05/21/received PY - 2020/07/09/revised PY - 2020/07/12/accepted PY - 2020/7/21/pubmed PY - 2020/9/30/medline PY - 2020/7/21/entrez KW - COVID-19 KW - Macrophages KW - Monocytes KW - Pathogenesis KW - SARS-CoV-2 SP - 118102 EP - 118102 JF - Life sciences JO - Life Sci VL - 257 N2 - The COVID-19-, SARS- and MERS-related coronaviruses share many genomic and structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and MERS-CoV. Despite some differences in the cytokine patterns, it seems that the cytokine storm plays a crucial role in the pathogenesis of COVID-19-, SARS- and MERS. Monocytes and macrophages may be infected by SARS-CoV-2 through ACE2-dependent and ACE2-independent pathways. SARS-CoV-2 can effectively suppress the anti-viral IFN response in monocytes and macrophages. Since macrophages and dendritic cells (DCs) act as antigen presenting cells (APCs), the infection of these cells by SARS-CoV-2 impairs the adaptive immune responses against the virus. Upon infection, monocytes migrate to the tissues where they become infected resident macrophages, allowing viruses to spread through all organs and tissues. The SARS-CoV-2-infected monocytes and macrophages can produce large amounts of numerous types of pro-inflammatory cytokines and chemokines, which contribute to local tissue inflammation and a dangerous systemic inflammatory response called cytokine storm. Both local tissue inflammation and the cytokine storm play a fundamental role in the development of COVID-19-related complications, such as acute respiratory distress syndrome (ARDS), which is a main cause of death in COVID-19 patients. Here, we describe the monocytes and macrophage responses during severe coronavirus infections, while highlighting potential therapeutic interventions to attenuate macrophage-related inflammatory reactions in possible approaches for COVID-19 treatment. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/32687918/Contribution_of_monocytes_and_macrophages_to_the_local_tissue_inflammation_and_cytokine_storm_in_COVID_19:_Lessons_from_SARS_and_MERS_and_potential_therapeutic_interventions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(20)30853-5 DB - PRIME DP - Unbound Medicine ER -