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Clinical characteristics of coronavirus disease 2019 in Gansu province, China.
Ann Palliat Med. 2020 Jul; 9(4):1404-1412.AP

Abstract

BACKGROUND

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has outbreak in the world. Little is known about the clinical characteristics of patients with SARS-CoV-2 infection in the high-altitude region of China. We reported the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) in Gansu province, China.

METHODS

In this retrospective study, patients with laboratory-confirmed SARS-CoV-2 infection were consecutively enrolled from January 21, 2020 to February 11, 2020. The information on the epidemiological, clinical characteristics, laboratory tests, radiological features on admission, treatment and outcome were obtained with the final follow-up of March 13, 2020. On the basis of the median length of hospital stay, patients were further analyzed in two groups (long- vs. short-hospital stay).

RESULTS

Of the 86 patients of COVID-19 in 11 cities of Gansu Province, the median hospital stay was 14.0 days (interquartile rang, 11.0-19.0 days). In the overall cohort, the median age was 41.0 years (interquartile rang, 31.0-54.3 years), and 48 (55.8%) patients were female. Forty (46.5%) had a history of exposure to epidemic regions, but none exposed to the Huanan seafood market in Wuhan. Common symptoms included fever (41, 47.7%), and cough (37, 43.0%). On admission, 30 (34.9%) and 58 (67.4%) patients had leukopenia and lymphopenia. According to chest CT scans, 53 (66.3%) of 80 patients showed bilateral pneumonia, and 19 (23.8%) of 80 patients showed unilateral pneumonia. Of the 15 asymptomatic cases, 10 (66.6%) cases were found CT findings of pneumonia. Besides, there were 65 (75.6%) patients with mild and moderate type of COVID-19. All 86 patients received antiviral and traditional Chinese medicine therapy, 53 (61.6%) received antibacterial therapy, and 3 (3.5%) patients received invasive ventilator mechanical ventilation. The proportion of patients received antibiotic treatment in long-hospital stay group was significantly higher than that in the short-hospital stay group (P=0.045). As of March 13, 2020, 84 (97.7%) patients were discharged, and two (2.3%) cases died.

CONCLUSIONS

In the Gansu province cohort of 86 patients of COVID-19, most patients were with mild or moderate type, and most asymptomatic cases showed CT imaging findings of SARS-CoV-2 related pneumonia.

Authors+Show Affiliations

Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China; CHESS Center, The First Hospital of Lanzhou University, Lanzhou, China. yuehongmei18@sina.com.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.CHESS Center, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.CHESS Center, The First Hospital of Lanzhou University, Lanzhou, China.CHESS Center, The First Hospital of Lanzhou University, Lanzhou, China.CHESS Center, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.CHESS Center, The First Hospital of Lanzhou University, Lanzhou, China.CHESS Center, The First Hospital of Lanzhou University, Lanzhou, China. qixiaolong@vip.163.com.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32692208

Citation

Yue, Hongmei, et al. "Clinical Characteristics of Coronavirus Disease 2019 in Gansu Province, China." Annals of Palliative Medicine, vol. 9, no. 4, 2020, pp. 1404-1412.
Yue H, Bai X, Wang J, et al. Clinical characteristics of coronavirus disease 2019 in Gansu province, China. Ann Palliat Med. 2020;9(4):1404-1412.
Yue, H., Bai, X., Wang, J., Yu, Q., Liu, W., Pu, J., Wang, X., Hu, J., Xu, D., Li, X., Kang, N., Li, L., Lu, W., Feng, T., Ding, L., Li, X., & Qi, X. (2020). Clinical characteristics of coronavirus disease 2019 in Gansu province, China. Annals of Palliative Medicine, 9(4), 1404-1412. https://doi.org/10.21037/apm-20-887
Yue H, et al. Clinical Characteristics of Coronavirus Disease 2019 in Gansu Province, China. Ann Palliat Med. 2020;9(4):1404-1412. PubMed PMID: 32692208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of coronavirus disease 2019 in Gansu province, China. AU - Yue,Hongmei, AU - Bai,Xue, AU - Wang,Jitao, AU - Yu,Qin, AU - Liu,Weiying, AU - Pu,Jiayuan, AU - Wang,Xiaoya, AU - Hu,Jianming, AU - Xu,Dan, AU - Li,Xiaoguo, AU - Kang,Ning, AU - Li,Long, AU - Lu,Wenqiang, AU - Feng,Tao, AU - Ding,Lihui, AU - Li,Xun, AU - Qi,Xiaolong, AU - ,, Y1 - 2020/07/13/ PY - 2020/04/04/received PY - 2020/06/10/accepted PY - 2020/7/22/pubmed PY - 2020/8/12/medline PY - 2020/7/22/entrez KW - Coronavirus disease 2019 (COVID-19) KW - Gansu province KW - severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) SP - 1404 EP - 1412 JF - Annals of palliative medicine JO - Ann Palliat Med VL - 9 IS - 4 N2 - BACKGROUND: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has outbreak in the world. Little is known about the clinical characteristics of patients with SARS-CoV-2 infection in the high-altitude region of China. We reported the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) in Gansu province, China. METHODS: In this retrospective study, patients with laboratory-confirmed SARS-CoV-2 infection were consecutively enrolled from January 21, 2020 to February 11, 2020. The information on the epidemiological, clinical characteristics, laboratory tests, radiological features on admission, treatment and outcome were obtained with the final follow-up of March 13, 2020. On the basis of the median length of hospital stay, patients were further analyzed in two groups (long- vs. short-hospital stay). RESULTS: Of the 86 patients of COVID-19 in 11 cities of Gansu Province, the median hospital stay was 14.0 days (interquartile rang, 11.0-19.0 days). In the overall cohort, the median age was 41.0 years (interquartile rang, 31.0-54.3 years), and 48 (55.8%) patients were female. Forty (46.5%) had a history of exposure to epidemic regions, but none exposed to the Huanan seafood market in Wuhan. Common symptoms included fever (41, 47.7%), and cough (37, 43.0%). On admission, 30 (34.9%) and 58 (67.4%) patients had leukopenia and lymphopenia. According to chest CT scans, 53 (66.3%) of 80 patients showed bilateral pneumonia, and 19 (23.8%) of 80 patients showed unilateral pneumonia. Of the 15 asymptomatic cases, 10 (66.6%) cases were found CT findings of pneumonia. Besides, there were 65 (75.6%) patients with mild and moderate type of COVID-19. All 86 patients received antiviral and traditional Chinese medicine therapy, 53 (61.6%) received antibacterial therapy, and 3 (3.5%) patients received invasive ventilator mechanical ventilation. The proportion of patients received antibiotic treatment in long-hospital stay group was significantly higher than that in the short-hospital stay group (P=0.045). As of March 13, 2020, 84 (97.7%) patients were discharged, and two (2.3%) cases died. CONCLUSIONS: In the Gansu province cohort of 86 patients of COVID-19, most patients were with mild or moderate type, and most asymptomatic cases showed CT imaging findings of SARS-CoV-2 related pneumonia. SN - 2224-5839 UR - https://www.unboundmedicine.com/medline/citation/32692208/Clinical_characteristics_of_coronavirus_disease_2019_in_Gansu_province_China_ L2 - https://doi.org/10.21037/apm-20-887 DB - PRIME DP - Unbound Medicine ER -