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COVID-19, cilia, and smell.
FEBS J. 2020 09; 287(17):3672-3676.FJ

Abstract

The novel coronavirus SARS-CoV-2 is the causative agent of the global coronavirus disease 2019 (COVID-19) outbreak. In addition to pneumonia, other COVID-19-associated symptoms have been reported, including loss of smell (anosmia). However, the connection between infection with coronavirus and anosmia remains enigmatic. It has been reported that defects in olfactory cilia lead to anosmia. In this Viewpoint, we summarize transmission electron microscopic studies of cilia in virus-infected cells. In the human nasal epithelium, coronavirus infects the ciliated cells and causes deciliation. Research has shown that viruses such as influenza and Sendai attach to the ciliary membrane. The Sendai virus enters cilia by fusing its viral membrane with the ciliary membrane. A recent study on SARS-CoV-2-human protein-protein interactions revealed that the viral nonstructural protein Nsp13 interacts with the centrosome components, providing a potential molecular link. The mucociliary escalator removes inhaled pathogenic particles and functions as the first line of protection mechanism against viral infection in the human airway. Thus, future investigation into the virus-cilium interface will help further the battle against COVID-19.

Authors+Show Affiliations

School of Medicine, Tsinghua University, Beijing, China.Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, School of Life Sciences, MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, School of Life Sciences, MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32692465

Citation

Li, Wei, et al. "COVID-19, Cilia, and Smell." The FEBS Journal, vol. 287, no. 17, 2020, pp. 3672-3676.
Li W, Li M, Ou G. COVID-19, cilia, and smell. FEBS J. 2020;287(17):3672-3676.
Li, W., Li, M., & Ou, G. (2020). COVID-19, cilia, and smell. The FEBS Journal, 287(17), 3672-3676. https://doi.org/10.1111/febs.15491
Li W, Li M, Ou G. COVID-19, Cilia, and Smell. FEBS J. 2020;287(17):3672-3676. PubMed PMID: 32692465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19, cilia, and smell. AU - Li,Wei, AU - Li,Ming, AU - Ou,Guangshuo, Y1 - 2020/08/06/ PY - 2020/05/27/received PY - 2020/06/26/revised PY - 2020/07/17/accepted PY - 2020/7/22/pubmed PY - 2020/12/29/medline PY - 2020/7/22/entrez KW - COVID-19 KW - SARS-CoV-2 KW - cilia KW - smell loss SP - 3672 EP - 3676 JF - The FEBS journal JO - FEBS J VL - 287 IS - 17 N2 - The novel coronavirus SARS-CoV-2 is the causative agent of the global coronavirus disease 2019 (COVID-19) outbreak. In addition to pneumonia, other COVID-19-associated symptoms have been reported, including loss of smell (anosmia). However, the connection between infection with coronavirus and anosmia remains enigmatic. It has been reported that defects in olfactory cilia lead to anosmia. In this Viewpoint, we summarize transmission electron microscopic studies of cilia in virus-infected cells. In the human nasal epithelium, coronavirus infects the ciliated cells and causes deciliation. Research has shown that viruses such as influenza and Sendai attach to the ciliary membrane. The Sendai virus enters cilia by fusing its viral membrane with the ciliary membrane. A recent study on SARS-CoV-2-human protein-protein interactions revealed that the viral nonstructural protein Nsp13 interacts with the centrosome components, providing a potential molecular link. The mucociliary escalator removes inhaled pathogenic particles and functions as the first line of protection mechanism against viral infection in the human airway. Thus, future investigation into the virus-cilium interface will help further the battle against COVID-19. SN - 1742-4658 UR - https://www.unboundmedicine.com/medline/citation/32692465/COVID_19_cilia_and_smell_ DB - PRIME DP - Unbound Medicine ER -