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Could Anise decrease the intensity of premenstrual syndrome symptoms in comparison to placebo? A double-blind randomized clinical trial.
J Complement Integr Med. 2020 Jul 08 [Online ahead of print]JC

Abstract

Background Premenstrual syndrome (PMS) has a high prevalence among women of reproductive ages but despite its high prevalence, it has no determined and absolute treatment, so far. So, the aim of the present study was to compare the effect Pimpinella Anisum (Anise) with placebo on the intensity of the symptoms of PMS. Methods The present study was a randomized double-blind controlled clinical trial. College students who were suffering from PMS and had the inclusion criteria were selected and randomly assigned into two groups of intervention (Anise) and control (placebo). Participants in the intervention group, received 110 mg capsules of Anise three times day (a total dose of 330 mg per day); the control group received similar capsules with the same dosing that contained starch. Consumption of the capsules was started 7 days before the start of the menstruation and continued until 3 days after, which was a total of 10 days during two consecutive menstruation cycles. The intensity of the symptoms of premenstrual syndrome was measured using Premenstrual Symptoms Screening Tool (PSST). To compare the intensity of the symptoms between the two study groups, generalized estimating equation statistical method was used. Results Eventually, sixty-seven 18-35 year old college students who were suffering from premenstrual syndrome were enrolled in the study. Comparing the mean score of the intensity of the syndrome between the two groups after the first and the second menstruation cycles showed a decrease in the intervention group to 13.9 (p-value<0.001; 95% CI: 16.5,-11.4) and 9.8 (p-value<0.001; 95% CI: 12.4,-7.3), respectively. Conclusion Results of the study showed that, in general, Anise was effective in decreasing the symptoms of premenstrual syndrome in comparison to placebo.

Authors+Show Affiliations

Research Institute for Endocrine Sciences, Reproductive Endocrinology Research Center, Shahid Beheshti University of Medical Sciences Tehran, Iran (Islamic Republic of). Nursing and Midwifery Care Research Center, Tehran University of Medical sciences, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Epidemiology and Biostatistics, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Nursing & Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32692701

Citation

Farahmand, Maryam, et al. "Could Anise Decrease the Intensity of Premenstrual Syndrome Symptoms in Comparison to Placebo? a Double-blind Randomized Clinical Trial." Journal of Complementary & Integrative Medicine, 2020.
Farahmand M, Khalili D, Ramezani Tehrani F, et al. Could Anise decrease the intensity of premenstrual syndrome symptoms in comparison to placebo? A double-blind randomized clinical trial. J Complement Integr Med. 2020.
Farahmand, M., Khalili, D., Ramezani Tehrani, F., Amin, G., & Negarandeh, R. (2020). Could Anise decrease the intensity of premenstrual syndrome symptoms in comparison to placebo? A double-blind randomized clinical trial. Journal of Complementary & Integrative Medicine. https://doi.org/10.1515/jcim-2019-0077
Farahmand M, et al. Could Anise Decrease the Intensity of Premenstrual Syndrome Symptoms in Comparison to Placebo? a Double-blind Randomized Clinical Trial. J Complement Integr Med. 2020 Jul 8; PubMed PMID: 32692701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Could Anise decrease the intensity of premenstrual syndrome symptoms in comparison to placebo? A double-blind randomized clinical trial. AU - Farahmand,Maryam, AU - Khalili,Davood, AU - Ramezani Tehrani,Fahimeh, AU - Amin,Gholamreza, AU - Negarandeh,Reza, Y1 - 2020/07/08/ PY - 2019/03/17/received PY - 2020/01/12/accepted PY - 2020/7/22/pubmed PY - 2020/7/22/medline PY - 2020/7/22/entrez KW - Pimpinella anisum KW - Premenstrual Symptoms Screening Tool KW - herbal medicine KW - phytoestrogen KW - premenstrual syndrome KW - starch JF - Journal of complementary & integrative medicine JO - J Complement Integr Med N2 - Background Premenstrual syndrome (PMS) has a high prevalence among women of reproductive ages but despite its high prevalence, it has no determined and absolute treatment, so far. So, the aim of the present study was to compare the effect Pimpinella Anisum (Anise) with placebo on the intensity of the symptoms of PMS. Methods The present study was a randomized double-blind controlled clinical trial. College students who were suffering from PMS and had the inclusion criteria were selected and randomly assigned into two groups of intervention (Anise) and control (placebo). Participants in the intervention group, received 110 mg capsules of Anise three times day (a total dose of 330 mg per day); the control group received similar capsules with the same dosing that contained starch. Consumption of the capsules was started 7 days before the start of the menstruation and continued until 3 days after, which was a total of 10 days during two consecutive menstruation cycles. The intensity of the symptoms of premenstrual syndrome was measured using Premenstrual Symptoms Screening Tool (PSST). To compare the intensity of the symptoms between the two study groups, generalized estimating equation statistical method was used. Results Eventually, sixty-seven 18-35 year old college students who were suffering from premenstrual syndrome were enrolled in the study. Comparing the mean score of the intensity of the syndrome between the two groups after the first and the second menstruation cycles showed a decrease in the intervention group to 13.9 (p-value<0.001; 95% CI: 16.5,-11.4) and 9.8 (p-value<0.001; 95% CI: 12.4,-7.3), respectively. Conclusion Results of the study showed that, in general, Anise was effective in decreasing the symptoms of premenstrual syndrome in comparison to placebo. SN - 1553-3840 UR - https://www.unboundmedicine.com/medline/citation/32692701/Could_Anise_decrease_the_intensity_of_premenstrual_syndrome_symptoms_in_comparison_to_placebo_A_double-blind_randomized_clinical_trial. L2 - https://www.degruyter.com/document/doi/10.1515/jcim-2019-0077 DB - PRIME DP - Unbound Medicine ER -
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