Tags

Type your tag names separated by a space and hit enter

Nodular secondary syphilis in three HIV-positive patients: a case series.
Int J STD AIDS. 2020 09; 31(10):1004-1007.IJ

Abstract

Nodular secondary syphilis is an uncommon variant of secondary syphilis. We identified three cases of nodular secondary syphilis at our institution. The first patient presented with a diffuse nodular rash that included his scrotum and penis. The second patient had disseminated skin-colored nodules with serosanguinous crust on his face, trunk, and extremities. The third patient had a pruritic papular and nodular rash with overlying crust. All three patients had a reactive rapid plasma reagin and tested positive for fluorescent treponemal antibody absorption. All were eventually confirmed to be human immunodeficiency virus-positive. Histopathological examination demonstrated inflammatory infiltrate in the dermis composed of lymphocytes, histiocytes, and plasma cells, and treponemal staining highlighted spirochetes in the dermis. The patients were successfully treated with intramuscular penicillin benzathine G. Physicians should be aware of nodular syphilis as a less common cutaneous manifestation of secondary syphilis. Prompt diagnosis of secondary syphilis can expedite resolution of the infection and avoid progression to tertiary syphilis.

Authors+Show Affiliations

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32693735

Citation

Wang, Catherine J., et al. "Nodular Secondary Syphilis in Three HIV-positive Patients: a Case Series." International Journal of STD & AIDS, vol. 31, no. 10, 2020, pp. 1004-1007.
Wang CJ, Leavens J, Thorpe J, et al. Nodular secondary syphilis in three HIV-positive patients: a case series. Int J STD AIDS. 2020;31(10):1004-1007.
Wang, C. J., Leavens, J., Thorpe, J., Crew, A., Kim, G., Ahronowitz, I., & Worswick, S. (2020). Nodular secondary syphilis in three HIV-positive patients: a case series. International Journal of STD & AIDS, 31(10), 1004-1007. https://doi.org/10.1177/0956462420933787
Wang CJ, et al. Nodular Secondary Syphilis in Three HIV-positive Patients: a Case Series. Int J STD AIDS. 2020;31(10):1004-1007. PubMed PMID: 32693735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nodular secondary syphilis in three HIV-positive patients: a case series. AU - Wang,Catherine J, AU - Leavens,Joan, AU - Thorpe,Joseph, AU - Crew,Ashley, AU - Kim,Gene, AU - Ahronowitz,Iris, AU - Worswick,Scott, Y1 - 2020/07/21/ PY - 2020/7/23/pubmed PY - 2021/6/10/medline PY - 2020/7/23/entrez KW - Syphilis (Treponema pallidum) KW - diagnosis KW - human immunodeficiency virus SP - 1004 EP - 1007 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 31 IS - 10 N2 - Nodular secondary syphilis is an uncommon variant of secondary syphilis. We identified three cases of nodular secondary syphilis at our institution. The first patient presented with a diffuse nodular rash that included his scrotum and penis. The second patient had disseminated skin-colored nodules with serosanguinous crust on his face, trunk, and extremities. The third patient had a pruritic papular and nodular rash with overlying crust. All three patients had a reactive rapid plasma reagin and tested positive for fluorescent treponemal antibody absorption. All were eventually confirmed to be human immunodeficiency virus-positive. Histopathological examination demonstrated inflammatory infiltrate in the dermis composed of lymphocytes, histiocytes, and plasma cells, and treponemal staining highlighted spirochetes in the dermis. The patients were successfully treated with intramuscular penicillin benzathine G. Physicians should be aware of nodular syphilis as a less common cutaneous manifestation of secondary syphilis. Prompt diagnosis of secondary syphilis can expedite resolution of the infection and avoid progression to tertiary syphilis. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/32693735/Nodular_secondary_syphilis_in_three_HIV_positive_patients:_a_case_series_ L2 - https://journals.sagepub.com/doi/10.1177/0956462420933787?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -