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Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine Development.
J Immunol Res. 2020; 2020:7201752.JI

Abstract

The recent outbreak of the novel coronavirus disease, COVID-19, has highlighted the threat that highly pathogenic coronaviruses have on global health security and the imminent need to design an effective vaccine for prevention purposes. Although several attempts have been made to develop vaccines against human coronavirus infections since the emergence of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) in 2003, there is no available licensed vaccine yet. A better understanding of previous coronavirus vaccine studies may help to design a vaccine for the newly emerged virus, SARS-CoV-2, that may also cover other pathogenic coronaviruses as a potentially universal vaccine. In general, coronavirus spike protein is the major antigen for the vaccine design as it can induce neutralizing antibodies and protective immunity. By considering the high genetic similarity between SARS-CoV and SARS-CoV-2, here, protective immunity against SARS-CoV spike subunit vaccine candidates in animal models has been reviewed to gain advances that can facilitate coronavirus vaccine development in the near future.

Authors+Show Affiliations

School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32695833

Citation

Khalaj-Hedayati, Atin. "Protective Immunity Against SARS Subunit Vaccine Candidates Based On Spike Protein: Lessons for Coronavirus Vaccine Development." Journal of Immunology Research, vol. 2020, 2020, p. 7201752.
Khalaj-Hedayati A. Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine Development. J Immunol Res. 2020;2020:7201752.
Khalaj-Hedayati, A. (2020). Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine Development. Journal of Immunology Research, 2020, 7201752. https://doi.org/10.1155/2020/7201752
Khalaj-Hedayati A. Protective Immunity Against SARS Subunit Vaccine Candidates Based On Spike Protein: Lessons for Coronavirus Vaccine Development. J Immunol Res. 2020;2020:7201752. PubMed PMID: 32695833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Immunity against SARS Subunit Vaccine Candidates Based on Spike Protein: Lessons for Coronavirus Vaccine Development. A1 - Khalaj-Hedayati,Atin, Y1 - 2020/07/18/ PY - 2020/04/27/received PY - 2020/06/09/accepted PY - 2020/7/23/entrez PY - 2020/7/23/pubmed PY - 2020/7/29/medline SP - 7201752 EP - 7201752 JF - Journal of immunology research JO - J Immunol Res VL - 2020 N2 - The recent outbreak of the novel coronavirus disease, COVID-19, has highlighted the threat that highly pathogenic coronaviruses have on global health security and the imminent need to design an effective vaccine for prevention purposes. Although several attempts have been made to develop vaccines against human coronavirus infections since the emergence of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) in 2003, there is no available licensed vaccine yet. A better understanding of previous coronavirus vaccine studies may help to design a vaccine for the newly emerged virus, SARS-CoV-2, that may also cover other pathogenic coronaviruses as a potentially universal vaccine. In general, coronavirus spike protein is the major antigen for the vaccine design as it can induce neutralizing antibodies and protective immunity. By considering the high genetic similarity between SARS-CoV and SARS-CoV-2, here, protective immunity against SARS-CoV spike subunit vaccine candidates in animal models has been reviewed to gain advances that can facilitate coronavirus vaccine development in the near future. SN - 2314-7156 UR - https://www.unboundmedicine.com/medline/citation/32695833/Protective_Immunity_against_SARS_Subunit_Vaccine_Candidates_Based_on_Spike_Protein:_Lessons_for_Coronavirus_Vaccine_Development_ L2 - https://doi.org/10.1155/2020/7201752 DB - PRIME DP - Unbound Medicine ER -