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Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome.
Crit Care Explor. 2020 Jun; 2(6):e0143.CC

Abstract

Objectives

To compare the clinical outcome of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome, who received corticosteroid with those who did not.

Design

Retrospective analysis.

Setting

Intensive care setting.

Patients

All adult mechanically ventilated patients, who were admitted to the ICU between March 20, 2020, and May 10, 2020, for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome.

Interventions

None.

Measurements and Main Results

Cohort was divided into two groups based on corticosteroid administration. The primary outcome variable was ventilator-free days at day 28. Secondary outcome variable was ICU-free days at day 30, and hospital-free days at day 30. Consecutive 61 mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome were analyzed. Patient in corticosteroid group as compared with noncorticosteroid group have higher 28-day ventilator-free days (mean, 10.2; median, 7 [interquartile range, 0-22.3] vs mean, 4.7; median, 0 [interquartile range, 0-11]; p = 0.01).There was no significant difference noted in secondary outcomes (ICU-free days at day 30 and hospital-free days at day 30).

Conclusions

Among mechanically ventilated severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome patients, corticosteroids use was associated with significant improvement in 28-day ventilator-free days at day 28, but no significant improvement in ICU-free days at day 30, and hospital-free days at day 30.

Authors+Show Affiliations

Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY.Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY.Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY.Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY.Department of Medicine, Albany Medical Center, Albany, NY.Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY.Department of Medicine, Albany Medical Center, Albany, NY.Department of Medicine, Albany Medical Center, Albany, NY.Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY.Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY.Department of Medicine, Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32696006

Citation

Chopra, Amit, et al. "Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome." Critical Care Explorations, vol. 2, no. 6, 2020, pp. e0143.
Chopra A, Chieng HC, Austin A, et al. Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome. Crit Care Explor. 2020;2(6):e0143.
Chopra, A., Chieng, H. C., Austin, A., Tiwari, A., Mehta, S., Nautiyal, A., Al-Tarbsheh, A. H., Jain, E., Feustel, P. J., Shkolnik, B., & Jaitovich, A. (2020). Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome. Critical Care Explorations, 2(6), e0143. https://doi.org/10.1097/CCE.0000000000000143
Chopra A, et al. Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome. Crit Care Explor. 2020;2(6):e0143. PubMed PMID: 32696006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corticosteroid Administration Is Associated With Improved Outcome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2-Related Acute Respiratory Distress Syndrome. AU - Chopra,Amit, AU - Chieng,Hau C, AU - Austin,Adam, AU - Tiwari,Anupama, AU - Mehta,Swati, AU - Nautiyal,Amit, AU - Al-Tarbsheh,Ali Hani, AU - Jain,Esha, AU - Feustel,Paul J, AU - Shkolnik,Boris, AU - Jaitovich,Ariel, Y1 - 2020/06/15/ PY - 2020/7/23/entrez PY - 2020/7/23/pubmed PY - 2020/7/23/medline KW - acute respiratory distress syndrome KW - corticosteroids KW - mechanical ventilator KW - outcome KW - severe acute respiratory syndrome coronavirus 2 SP - e0143 EP - e0143 JF - Critical care explorations JO - Crit Care Explor VL - 2 IS - 6 N2 - Objectives: To compare the clinical outcome of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome, who received corticosteroid with those who did not. Design: Retrospective analysis. Setting: Intensive care setting. Patients: All adult mechanically ventilated patients, who were admitted to the ICU between March 20, 2020, and May 10, 2020, for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome. Interventions: None. Measurements and Main Results: Cohort was divided into two groups based on corticosteroid administration. The primary outcome variable was ventilator-free days at day 28. Secondary outcome variable was ICU-free days at day 30, and hospital-free days at day 30. Consecutive 61 mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome were analyzed. Patient in corticosteroid group as compared with noncorticosteroid group have higher 28-day ventilator-free days (mean, 10.2; median, 7 [interquartile range, 0-22.3] vs mean, 4.7; median, 0 [interquartile range, 0-11]; p = 0.01).There was no significant difference noted in secondary outcomes (ICU-free days at day 30 and hospital-free days at day 30). Conclusions: Among mechanically ventilated severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome patients, corticosteroids use was associated with significant improvement in 28-day ventilator-free days at day 28, but no significant improvement in ICU-free days at day 30, and hospital-free days at day 30. SN - 2639-8028 UR - https://www.unboundmedicine.com/medline/citation/32696006/Corticosteroid_Administration_Is_Associated_With_Improved_Outcome_in_Patients_With_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Related_Acute_Respiratory_Distress_Syndrome_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=32696006.ui DB - PRIME DP - Unbound Medicine ER -