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Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series.
Arch Gynecol Obstet. 2020 09; 302(3):545-551.AG

Abstract

OBJECTIVE

To investigate the maternal and infant outcomes of full-term pregnant patients in Wuhan, China, who were infected with 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for coronavirus disease 2019 (COVID-2019).

DESIGN

Retrospective case series.

SETTING

The Central Hospitals of Wuhan, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China.

PARTICIPANTS

Twenty one full-term pregnant patients who were admitted to the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, confirmed SARS-CoV-2 infection and COVID-2019 with laboratorial and clinical methods, were reviewed by our medical team, and the data were collected from January 20, 2020 to February 29, 2020.

MAIN CLINICAL DATA COLLECTION

Clinical data had been collecting using a standard case report form, such as epidemiological history, clinical manifestations, auxiliary examination of major laboratory and clinic, etc. All the information was collected and confirmed by our medical team.

RESULTS

Twenty one full-term pregnant patients were reviewed (median age 29 years), and no patients were admitted to intensive care unit (ICU), and died during the treating progress. According to our review, all the cases were infected by human to human transmission, and the most common symptoms at onset of illness were cough in 17 (80.95%), fatigue in 10 (47.62%), fever in 7 (33.33%), expectoration in 1 (4.76%), and only one patient (4.76%) developed shortness of breath on admission. The median time from exposure to onset of illness was 10 days (interquartile range 7 -2 days), and from onset of symptoms to first hospital admission was 1 day (interquartile range 1-2 days).

CONCLUSIONS

As of February 29, 2020, all the patients who were full-term pregnancy combined with COVID-2019 were cured and delivered successfully, and all the newborns were not infected with SARS-CoV-2, and there were no evidence of mother-to-child transmission.

Authors+Show Affiliations

Department of Obstetrics, The Center Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, People's Republic of China.Department of Obstetrics and Gynecology, The First People's Hospital of Datong, 336 Hengan Avenue, Datong, 037000, People's Republic of China. baijunjinanu@163.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32696241

Citation

Chen, Yanfen, and Jun Bai. "Maternal and Infant Outcomes of Full-term Pregnancy Combined With COVID-2019 in Wuhan, China: Retrospective Case Series." Archives of Gynecology and Obstetrics, vol. 302, no. 3, 2020, pp. 545-551.
Chen Y, Bai J. Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series. Arch Gynecol Obstet. 2020;302(3):545-551.
Chen, Y., & Bai, J. (2020). Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series. Archives of Gynecology and Obstetrics, 302(3), 545-551. https://doi.org/10.1007/s00404-020-05573-8
Chen Y, Bai J. Maternal and Infant Outcomes of Full-term Pregnancy Combined With COVID-2019 in Wuhan, China: Retrospective Case Series. Arch Gynecol Obstet. 2020;302(3):545-551. PubMed PMID: 32696241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series. AU - Chen,Yanfen, AU - Bai,Jun, Y1 - 2020/07/21/ PY - 2020/03/28/received PY - 2020/04/26/accepted PY - 2020/7/23/pubmed PY - 2020/9/8/medline PY - 2020/7/23/entrez KW - COVID-2019 KW - Full-term pregnant patients KW - SARS-CoV-2 SP - 545 EP - 551 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 302 IS - 3 N2 - OBJECTIVE: To investigate the maternal and infant outcomes of full-term pregnant patients in Wuhan, China, who were infected with 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for coronavirus disease 2019 (COVID-2019). DESIGN: Retrospective case series. SETTING: The Central Hospitals of Wuhan, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China. PARTICIPANTS: Twenty one full-term pregnant patients who were admitted to the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, confirmed SARS-CoV-2 infection and COVID-2019 with laboratorial and clinical methods, were reviewed by our medical team, and the data were collected from January 20, 2020 to February 29, 2020. MAIN CLINICAL DATA COLLECTION: Clinical data had been collecting using a standard case report form, such as epidemiological history, clinical manifestations, auxiliary examination of major laboratory and clinic, etc. All the information was collected and confirmed by our medical team. RESULTS: Twenty one full-term pregnant patients were reviewed (median age 29 years), and no patients were admitted to intensive care unit (ICU), and died during the treating progress. According to our review, all the cases were infected by human to human transmission, and the most common symptoms at onset of illness were cough in 17 (80.95%), fatigue in 10 (47.62%), fever in 7 (33.33%), expectoration in 1 (4.76%), and only one patient (4.76%) developed shortness of breath on admission. The median time from exposure to onset of illness was 10 days (interquartile range 7 -2 days), and from onset of symptoms to first hospital admission was 1 day (interquartile range 1-2 days). CONCLUSIONS: As of February 29, 2020, all the patients who were full-term pregnancy combined with COVID-2019 were cured and delivered successfully, and all the newborns were not infected with SARS-CoV-2, and there were no evidence of mother-to-child transmission. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/32696241/Maternal_and_infant_outcomes_of_full_term_pregnancy_combined_with_COVID_2019_in_Wuhan_China:_retrospective_case_series_ L2 - https://dx.doi.org/10.1007/s00404-020-05573-8 DB - PRIME DP - Unbound Medicine ER -