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Self-Amplifying RNA Viruses as RNA Vaccines.
Int J Mol Sci. 2020 Jul 20; 21(14)IJ

Abstract

Single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses and rhabdoviruses are characterized by their capacity of highly efficient self-amplification of RNA in host cells, which make them attractive vehicles for vaccine development. Particularly, alphaviruses and flaviviruses can be administered as recombinant particles, layered DNA/RNA plasmid vectors carrying the RNA replicon and even RNA replicon molecules. Self-amplifying RNA viral vectors have been used for high level expression of viral and tumor antigens, which in immunization studies have elicited strong cellular and humoral immune responses in animal models. Vaccination has provided protection against challenges with lethal doses of viral pathogens and tumor cells. Moreover, clinical trials have demonstrated safe application of RNA viral vectors and even promising results in rhabdovirus-based phase III trials on an Ebola virus vaccine. Preclinical and clinical applications of self-amplifying RNA viral vectors have proven efficient for vaccine development and due to the presence of RNA replicons, amplification of RNA in host cells will generate superior immune responses with significantly reduced amounts of RNA delivered. The need for novel and efficient vaccines has become even more evident due to the global COVID-19 pandemic, which has further highlighted the urgency in challenging emerging diseases.

Authors+Show Affiliations

PanTherapeutics, CH1095 Lutry, Switzerland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32698494

Citation

Lundstrom, Kenneth. "Self-Amplifying RNA Viruses as RNA Vaccines." International Journal of Molecular Sciences, vol. 21, no. 14, 2020.
Lundstrom K. Self-Amplifying RNA Viruses as RNA Vaccines. Int J Mol Sci. 2020;21(14).
Lundstrom, K. (2020). Self-Amplifying RNA Viruses as RNA Vaccines. International Journal of Molecular Sciences, 21(14). https://doi.org/10.3390/ijms21145130
Lundstrom K. Self-Amplifying RNA Viruses as RNA Vaccines. Int J Mol Sci. 2020 Jul 20;21(14) PubMed PMID: 32698494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-Amplifying RNA Viruses as RNA Vaccines. A1 - Lundstrom,Kenneth, Y1 - 2020/07/20/ PY - 2020/06/30/received PY - 2020/07/15/revised PY - 2020/07/16/accepted PY - 2020/7/24/entrez PY - 2020/7/24/pubmed PY - 2020/8/4/medline KW - RNA replicons KW - RNA vaccines KW - RNA vectors KW - immune responses KW - protection against pathogens KW - protection against tumor challenges JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 14 N2 - Single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses and rhabdoviruses are characterized by their capacity of highly efficient self-amplification of RNA in host cells, which make them attractive vehicles for vaccine development. Particularly, alphaviruses and flaviviruses can be administered as recombinant particles, layered DNA/RNA plasmid vectors carrying the RNA replicon and even RNA replicon molecules. Self-amplifying RNA viral vectors have been used for high level expression of viral and tumor antigens, which in immunization studies have elicited strong cellular and humoral immune responses in animal models. Vaccination has provided protection against challenges with lethal doses of viral pathogens and tumor cells. Moreover, clinical trials have demonstrated safe application of RNA viral vectors and even promising results in rhabdovirus-based phase III trials on an Ebola virus vaccine. Preclinical and clinical applications of self-amplifying RNA viral vectors have proven efficient for vaccine development and due to the presence of RNA replicons, amplification of RNA in host cells will generate superior immune responses with significantly reduced amounts of RNA delivered. The need for novel and efficient vaccines has become even more evident due to the global COVID-19 pandemic, which has further highlighted the urgency in challenging emerging diseases. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32698494/Self_Amplifying_RNA_Viruses_as_RNA_Vaccines_ L2 - https://www.mdpi.com/resolver?pii=ijms21145130 DB - PRIME DP - Unbound Medicine ER -