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Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19.
Br J Pharmacol. 2020 11; 177(21):4899-4920.BJ

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the novel coronavirus disease 2019 (COVID-19), a highly pathogenic and sometimes fatal respiratory disease responsible for the current 2020 global pandemic. Presently, there remains no effective vaccine or efficient treatment strategies against COVID-19. Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines very widely used to alleviate fever, pain, and inflammation (common symptoms of COVID-19 patients) through effectively blocking production of prostaglandins (PGs) via inhibition of cyclooxyganase enzymes. PGs can exert either proinflammatory or anti-inflammatory effects depending on the inflammatory scenario. In this review, we survey the potential roles that NSAIDs and PGs may play during SARS-CoV-2 infection and the development and progression of COVID-19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc.

Authors+Show Affiliations

Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32700336

Citation

Robb, Calum T., et al. "Non-steroidal Anti-inflammatory Drugs, Prostaglandins, and COVID-19." British Journal of Pharmacology, vol. 177, no. 21, 2020, pp. 4899-4920.
Robb CT, Goepp M, Rossi AG, et al. Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19. Br J Pharmacol. 2020;177(21):4899-4920.
Robb, C. T., Goepp, M., Rossi, A. G., & Yao, C. (2020). Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19. British Journal of Pharmacology, 177(21), 4899-4920. https://doi.org/10.1111/bph.15206
Robb CT, et al. Non-steroidal Anti-inflammatory Drugs, Prostaglandins, and COVID-19. Br J Pharmacol. 2020;177(21):4899-4920. PubMed PMID: 32700336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19. AU - Robb,Calum T, AU - Goepp,Marie, AU - Rossi,Adriano G, AU - Yao,Chengcan, Y1 - 2020/08/27/ PY - 2020/06/17/received PY - 2020/07/09/revised PY - 2020/07/13/accepted PY - 2020/7/24/pubmed PY - 2020/10/28/medline PY - 2020/7/24/entrez KW - COVID-19 KW - NSAID KW - SARS-CoV-2 KW - cytokine storm KW - inflammation KW - prostaglandin SP - 4899 EP - 4920 JF - British journal of pharmacology JO - Br J Pharmacol VL - 177 IS - 21 N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the novel coronavirus disease 2019 (COVID-19), a highly pathogenic and sometimes fatal respiratory disease responsible for the current 2020 global pandemic. Presently, there remains no effective vaccine or efficient treatment strategies against COVID-19. Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines very widely used to alleviate fever, pain, and inflammation (common symptoms of COVID-19 patients) through effectively blocking production of prostaglandins (PGs) via inhibition of cyclooxyganase enzymes. PGs can exert either proinflammatory or anti-inflammatory effects depending on the inflammatory scenario. In this review, we survey the potential roles that NSAIDs and PGs may play during SARS-CoV-2 infection and the development and progression of COVID-19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. SN - 1476-5381 UR - https://www.unboundmedicine.com/medline/citation/32700336/Non_steroidal_anti_inflammatory_drugs_prostaglandins_and_COVID_19_ DB - PRIME DP - Unbound Medicine ER -